fibroblast growth factor 23
- CAS No.
- Chemical Name:
- fibroblast growth factor 23
- Synonyms
- FGF-23;DI1;ADHR;HYPF;FGFN;Avp2r;PHPTC;AVPR2;HPDR2;AVPR V2
- CBNumber:
- CB91383141
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | buffered aqueous solution |
| biological source | rabbit |
| FDA UNII | 7Q7P4S7RRE |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
fibroblast growth factor 23 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3039 | FGF-23 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture | 20 μg | $381 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SAB4503210 | Anti-FGF23 antibody produced in rabbit affinity isolated antibody | 100μg | $560 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SAB2502007 | Anti-Fgf23 antibody produced in goat affinity isolated antibody, buffered aqueous solution | 100μG | $628 | 2026-04-30 | Buy | |
| Usbiological | 154589 | Fibroblast Growth Factor 23 | 10ug | $350 | 2021-12-16 | Buy | |
| Usbiological | 154590 | Fibroblast Growth Factor 23 | 10ug | $350 | 2021-12-16 | Buy |
fibroblast growth factor 23 Chemical Properties, Uses, Production
Uses
Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone which is secreted by osteocytes and osteoblasts. It is part of the atypical FGF subfamily. The gene encoding it is localized on human chromosome 12p13. Anti-FGF23 Antibody detects endogenous levels of total FGF23 protein.
Biological Activity
The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. Fibroblast growth factor-23, -21 and -19 (FGF-23, FGF-21 and FGF-19) act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and cytochrome P450 family 24 subfamily A member 1 (CYP24A1). FGF-23 acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism.
Description
Fibroblast Growth Factor-23 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing a total of 228 amino acids and having a molecular mass of 22.5kDa.
The FGF-23 is and purified by chromatographic techniques.
Source
Escherichia Coli
Background
FGF-23 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-23 inhibits renal tubular phosphate transport. The FGF-23 gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of FGF-23 was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. FGF-23 mutations have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
fibroblast growth factor 23 Preparation Products And Raw materials
Raw materials
Preparation Products
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