pyripyropene A
- CAS No.
- 147444-03-9
- Chemical Name:
- pyripyropene A
- Synonyms
- FO 1289A;pyripyropene A;Pyripyropene A, ACAT2 inhibitor;2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one, 3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-, (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-
- CBNumber:
- CB91387745
- Molecular Formula:
- C31H37NO10
- Molecular Weight:
- 583.63
- MDL Number:
- MFCD00929109
- MOL File:
- 147444-03-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pyripyropene A ≥95% | 11896 | 250μg | $153 |
| Pyripyropene A ≥95% | 11896 | 1mg | $456 |
| Pyripyropene A | 045185 | 250ug | $358 |
| PYRIPYROPENE A 95.00% | INB0004030 | 5MG | $497.27 |
| PyripyropeneA | 1162CT | 1mg | $606 |
| Melting point | 153-154℃ |
|---|---|
| Boiling point | 690.8±55.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C, protect from light, stored under nitrogen |
| solubility | DMSO: Soluble; Methanol: Soluble |
| pka | 11.72±0.70(Predicted) |
| form | White to brown powder. |
| color | Pale pink to rusty brown |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
pyripyropene A price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11896 | Pyripyropene A ≥95% | 147444-03-9 | 250μg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 11896 | Pyripyropene A ≥95% | 147444-03-9 | 1mg | $456 | 2024-03-01 | Buy |
| Usbiological | 045185 | Pyripyropene A | 147444-03-9 | 250ug | $358 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004030 | PYRIPYROPENE A 95.00% | 147444-03-9 | 5MG | $497.27 | 2021-12-16 | Buy |
| AK Scientific | 1162CT | PyripyropeneA | 147444-03-9 | 1mg | $606 | 2021-12-16 | Buy |
pyripyropene A Chemical Properties,Uses,Production
Uses
Pyripyropene A exhibits insecticidal properties and a useful compound for developing agrichemicals.
Definition
ChEBI: A sesquiterpenoid that consists of (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-o o-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diol in which the hydrogens of the 3- and 6-hydroxy functions are substituted by acetyl groups.
in vivo
Pyripyropene A (10-50 mg/kg per day; p.o; 12 weeks) reduces the levels of plasma cholesterol, very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) and hepatic cholesterol content in apolipoprotein E-knockout mice. And Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart[3].
Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2 (ACAT2) activity in vivo[3].
Pyripyropene A displays a half-life (t1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile[4].
| Animal Model: | Male C57BL/6 mice[2] |
| Dosage: | 0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration; daily; for 12 weeks |
| Result: | Reduced atherogenic lesion areas in the aortae and heart. |
| Animal Model: | 9-week old male ICR mice (pharmacokinetic analysis)[4] |
| Dosage: | 5 mg/kg ,10 mg/kg |
| Administration: | Oral administration |
| Result: | t1/2 = 0.693/λ |
storage
+4°C
pyripyropene A Preparation Products And Raw materials
pyripyropene A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| Chongqing Qiantai Pharma Co., Ltd. | +8615862471140 | richardchan@bright-gene.com | China | 84 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 26685 | 65 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 | shenlinxing@macklin.cn | China | 15781 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4827 | 55 | |
| INTERCHEMIE NANJING PHARMATECH CO., LTD | 13656237714 13656237714; | xiaokunfu@kyyykj.com | China | 299 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
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