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2-Hydroxy-3-cyanopyridine

2-Hydroxy-3-cyanopyridine structure

CAS No.: 20577-27-9

Chemical Name:: 2-Hydroxy-3-cyanopyridine

Synonyms: 3-Cyano-2-pyridone;3-Cyano-2-pyridinol;3-CYANO-2(1H)-PYRIDINONE;3-Cyano-1H-pyridin-2-one;2-Hydroxynicotinonitrile;3-Cyanopyridin-2(1H)-one;2-Hydroy-3-cyanopyridine;2-Hydroxy-3-cycnopyridine;2-Hydroxy-3-cyanopyridine;2-HYDROXY-3-PYRIDINECARBONITRILE

CBNumber:: CB9141849

Molecular Formula:: C6H4N2O

Molecular Weight:: 120.11

MDL Number:: MFCD00661865

MOL File:: 20577-27-9.mol

Last updated:2025-07-24 18:13:46

Product description	Number	Pack Size	Price
2-Hydroxy-3-cyanopyridine	H825140	10g	$135
2-Hydroxy-3-cyanopyridine	10706	5G	$290
2-Oxo-2,3-dihydropyridine-3-carbonitrile 95%	153011	25g	$334
3-Cyano-2-hydroxypyridine	FC09747	25g	$131.25
3-Cyano-2-hydroxypyridine	W4330	5g	$32
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2-Hydroxy-3-cyanopyridine Properties

Melting point	90-94
Boiling point	352.3±35.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in dimethyl sulfoxide.
form	Solid
pka	8.93±0.10(Predicted)
InChI	InChI=1S/C6H4N2O/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9)
InChIKey	DYUMBFTYRJMAFK-UHFFFAOYSA-N
SMILES	C1(=O)NC=CC=C1C#N
CAS DataBase Reference	20577-27-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

22-41

Safety Statements

26-39

RIDADR

UN3439

Hazard Note

Irritant/Keep Cold

HazardClass

6.1

HS Code

2933399990

NFPA 704

	1
2		0

2-Hydroxy-3-cyanopyridine price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	H825140	2-Hydroxy-3-cyanopyridine	20577-27-9	10g	$135	2021-12-16	Buy
Medical Isotopes, Inc.	10706	2-Hydroxy-3-cyanopyridine	20577-27-9	5G	$290	2021-12-16	Buy
Matrix Scientific	153011	2-Oxo-2,3-dihydropyridine-3-carbonitrile 95%	20577-27-9	25g	$334	2021-12-16	Buy
Biosynth Carbosynth	FC09747	3-Cyano-2-hydroxypyridine	20577-27-9	25g	$131.25	2021-12-16	Buy
AK Scientific	W4330	3-Cyano-2-hydroxypyridine	20577-27-9	5g	$32	2021-12-16	Buy

Product number	Packaging	Price	Buy
H825140	10g	$135	Buy
10706	5G	$290	Buy
153011	25g	$334	Buy
FC09747	25g	$131.25	Buy
W4330	5g	$32	Buy

2-Hydroxy-3-cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

Dark Yellow Solid

Uses

2-Hydroxy-3-cyanopyridine (cas# 20577-27-9) is a compound useful in organic synthesis.

Definition

ChEBI: 3-cyano-2-pyridone is a member of pyridines and a nitrile.

Synthesis

6602-54-6

20577-27-9

The general procedure for the synthesis of 2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-chloro-3-cyanopyridine was as follows: acetic acid (826 mL) was slowly added to 2-chloro-3-cyanopyridine (250 g), and the mixture was subsequently heated to reflux and held for 48 hours. Upon completion of the reaction, the reaction mixture was quenched by careful pouring into an ice-water mixture. The resulting precipitate was collected by filtration, washed well with deionized water and dried under appropriate conditions to give the target product 2-hydroxy-3-cyanopyridine. The yield of this step was 95%. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 12.57 (s, 1H), 8.16 (dd, J = 3.6 Hz, 1H), 7.80 (dd, J = 3.6 Hz, 1H), 6.37 (t, 1H); the mass spectrum (ES) showed m/z of 121.

References

[1] Tetrahedron Letters, 2004, vol. 45, # 35, p. 6633 - 6636
[2] Patent: WO2014/207508, 2014, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7624 - 7643
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5738 - 5746
[5] Synthetic Communications, 2011, vol. 41, # 19, p. 2859 - 2869

2-Hydroxy-3-cyanopyridine synthesis

Synthesis of 2-Hydroxy-3-cyanopyridine from 2-Chloro-3-cyanopyridine

2-Hydroxy-3-cyanopyridine Preparation Products And Raw materials

Raw materials

2-Chloro-3-cyanopyridine

Preparation Products

2-Hydroxynicotinic acid 2-HYDROXY-5-NITRONICOTINONITRILE 5-Bromo-3-cyano-2-hydroxypyridine

2-Hydroxy-3-cyanopyridine Suppliers

Global( 208)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	+86-025-84918180 +86-18014482516	3552541679@qq.com	China	997	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Nanjing Yushan Wanfang Biotechnology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-Hydroxy-3-cyanopyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	2-Hydroxy-3-cyanopyridine 20577-27-9	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-06-25	2-Hydroxy-3-cyanopyridine 20577-27-9	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2021-10-16	2-Hydroxy-3-cyanopyridine 20577-27-9	US $10.00 / KG	1KG	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd

2-Hydroxy-3-cyanopyridine
20577-27-9
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2-Hydroxy-3-cyanopyridine
20577-27-9
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Hydroxy-3-cyanopyridine
20577-27-9
US $10.00 / KG
99%
Hebei Zhanyao Biotechnology Co. Ltd

2-Hydroxy-3-cyanopyridine Spectrum

2-Hydroxy-3-cyanopyridine(20577-27-9)¹HNMR

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2-Hydroxy-3-cycnopyridine 2-Oxo-2,3-dihydropyridine-3-carbonitrile 3-CYANO-2(1H)-PYRIDINONE 2-HYDROXY-3-PYRIDINECARBONITRILE 2-Hydroxy-3-cyanopyridine 1,2-Dihydro-2-oxopyridine-3-carbonitrile 1,2-Dihydropyridine-2-oxo-3-carbonitrile 3-Cyano-1H-pyridin-2-one 1,2-Dihydro-2-oxopyridine-3-carbonitrile 98% 2-Hydroxypyridine-3-carbonitrile, 3-Cyano-2-hydroxypyridine 1,2-Dihydropyridine-2-oxo-3-carbonitrile98% 2-Hydroxynicotinonitrile 3-Cyanopyridin-2(1H)-one 3-Cyano-2-pyridinol 3-Cyano-2-pyridone 3-Pyridinecarbonitrile, 1,2-dihydro-2-oxo- 2-Hydroxy-3-cyanopyridine ISO 9001：2015 REACH 2-Hydroy-3-cyanopyridine 2-oxo-1,2-dihydropyridine-3-carbonitrile2-hydroxy-3-cyanopyridine 20577-27-9 200577-27-9 Bases & Related Reagents Nucleotides Nucleotides and Nucleosides CHIRAL CHEMICALS cyanide| alcohol Heterocycle-Pyridine series Pyridine blocks Carboxes Pyridines Chemical Synthesis Heterocyclic Building Blocks New Products for Chemical Synthesis Building Blocks C6