5-FLUORO-2-THIOPHENECARBOXYLIC ACID
- CAS No.
- 4377-58-6
- Chemical Name:
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
- Synonyms
- AKOS B029946;4-fluorothiop;5-Carboxy-2-fluorothiophene;5-Fluoro-thiophene-2-carb...;5-Fluorothiophen-2-carboxylic acid;5-FLUORO-2-THIOPHENECARBOXYLIC ACID;4-fluorothiophene-2-carboxylic acid;5-Fluoro-thiophene-2-carboxylic acid;2-Thiophenecarboxylicacid, 5-fluoro-
- CBNumber:
- CB9144895
- Molecular Formula:
- C5H3FO2S
- Molecular Weight:
- 146.14
- MDL Number:
- MFCD07787557
- MOL File:
- 4377-58-6.mol
| Melting point | 139-141℃ |
|---|---|
| Boiling point | 271.2±20.0 °C(Predicted) |
| Density | 1.527±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 3.52±0.10(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C5H3FO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8) |
| InChIKey | XQURBTZGKJENJS-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)SC(F)=CC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
5-FLUORO-2-THIOPHENECARBOXYLIC ACID price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F402378 | 5-Fluorothiophene-2-carboxylicAcid | 4377-58-6 | 50mg | $65 | 2021-12-16 | Buy |
| TRC | F402378 | 5-Fluorothiophene-2-carboxylicAcid | 4377-58-6 | 100mg | $90 | 2021-12-16 | Buy |
| TRC | F402378 | 5-Fluorothiophene-2-carboxylicAcid | 4377-58-6 | 500mg | $330 | 2021-12-16 | Buy |
| AK Scientific | W6292 | 5-Fluoro-2-thiophenecarboxylicacid | 4377-58-6 | 250mg | $182 | 2021-12-16 | Buy |
| ChemScene | CS-D0304 | 5-Fluorothiophene-2-carboxylicacid | 4377-58-6 | 1g | $242 | 2021-12-16 | Buy |
5-FLUORO-2-THIOPHENECARBOXYLIC ACID Chemical Properties,Uses,Production
Synthesis
32415-91-1
4377-58-6
General procedure for the synthesis of 5-fluorothiophene-2-carboxylic acid from 5-fluorothiophene-2-carbonitrile: 138 mg (1.07 mmol) of 5-fluorothiophene-2-carbonitrile and 5 ml of 1N sodium hydroxide solution were added to an eggplant flask, and the mixture was heated and stirred in an oil bath at 100 °C for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature. Subsequently, 5 ml of water was added to the reaction solution for dilution and the pH was adjusted with 10 ml of 1N hydrochloric acid to 1. Next, the mixture was extracted twice with 30 ml of dichloromethane. The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give 110 mg of 5-fluorothiophene-2-carboxylic acid.
References
[1] Patent: US6043379, 2000, A
[2] Patent: US6096901, 2000, A
[3] Patent: US2013/137730, 2013, A1. Location in patent: Paragraph 0092
5-FLUORO-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials
5-FLUORO-2-THIOPHENECARBOXYLIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29801 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9243 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Wuhan Golt Biotech Co., Ltd. | +8615389281203 | maria@goltbiotech.com | China | 970 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from 5-FLUORO-2-THIOPHENECARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
4377-58-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-10 | 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
4377-58-6
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
4377-58-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
4377-58-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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