1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole
![1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole Structure](CAS/GIF/188113-71-5.gif)
- CAS No.
- 188113-71-5
- Chemical Name:
- 1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole
- Synonyms
- N-Acetyl-dehydro-Eletriptan;Eletriptan Dehydro N-Acetyl Imp;Eletriptan Dehydro N-Acetyl Impurity;1-ACETYL-3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE;(R)-1-ACETYL-5(2-BENZENE SULPHONYL ETHENYL)-3-(N-METHYLPYRROLIDIN-2-YL-METHYL-1H-INDOLE;(R)-1-(3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone;1-[3-[[(2R)-1-METHYL-2-PYRROLIDINYL]METHYL]-5-[(1E)-2-(PHENYLSULFONYL)ETHENYL]-1H-INDOL-1-YL]-;(S,E)-1-(3-((1-Methylpyrrolidin-2-yl)Methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone;(R,E)-1-(3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone;1-[3-[[(2R)-1-METHYL-2-PYRROLIDINYL]METHYL]-5-[(1E)-2-(PHENYLSULFONYL)ETHENYL]-1H-INDOL-1-YL]ETHANONE
- CBNumber:
- CB91473844
- Molecular Formula:
- C24H26N2O3S
- Molecular Weight:
- 422.54
- MDL Number:
- MFCD22989071
- MOL File:
- 188113-71-5.mol
| Product description | Number | Pack Size | Price |
| N-Acetyl-dehydro-Eletriptan | A172285 | 25mg | $1190 |
| (R)-1-(3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone 95%+ | CM333831 | 5g | $272 |
| (R)-1-(3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone 95%+ | CM333831 | 10g | $440 |
| More product size | |||
| Melting point | >85°C (dec.) |
|---|---|
| Boiling point | 620.7±55.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.20±0.40(Predicted) |
| form | Solid |
| color | Pale Beige to Light Brown |
| Stability | Light Sensitive |
| InChIKey | MDVODIFOKYRNHD-ZISLFAKRSA-N |
| SMILES | C(=O)(N1C2=C(C=C(/C=C/S(C3=CC=CC=C3)(=O)=O)C=C2)C(C[C@H]2CCCN2C)=C1)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H318 |
| Precautionary statements | P261-P272-P280-P302+P352-P305+P351+P338-P310-P321-P333+P313-P363-P501 |
1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A172285 | N-Acetyl-dehydro-Eletriptan | 188113-71-5 | 25mg | $1190 | 2021-12-16 | Buy |
| Chemenu | CM333831 | (R)-1-(3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone 95%+ | 188113-71-5 | 5g | $272 | 2021-12-16 | Buy |
| Chemenu | CM333831 | (R)-1-(3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethanone 95%+ | 188113-71-5 | 10g | $440 | 2021-12-16 | Buy |
1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole Chemical Properties,Uses,Production
Uses
N-Acetyl-dehydro-Eletriptan (1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole), is the impurity of Eletriptan (E505000), which is A serotonin 5-HTIB/ID receptor agonist, used for the treatment of migraine headaches.
Hazard
1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole has acute toxicity, causes skin irritation and severe eye irritation.
Synthesis
1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole can be synthesized as follows: Charge a sealable reaction tube equipped with a stirring bar with Pd (OAc)2 (4.5 mg, 0.02 mmol, 2 mol %), Dicyclohexyl[2′,4′,6′-tris(1-methylethyl)[1,1′:3′,1′′-terphenyl]-2-yl]phosphine (22.4 mg, 0.04 mmol, 4 mol %) and NaHCO3 (202 mg, 2.4 mmol). Add the phenyl vinyl sulfone (109 mg, 0.65 mmol), 1-[5-Bromo-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indol-1-yl]ethanone (168 mg, 0.5 mmol) and 2 mL of DMF to the reaction. Seal the tube with a Teflon-lined septum and heat to 16 h with vigorous stirring. Cool the suspension to room temperature, dilute with EtOAc and filter througha pad of Celite. Concentrate the filtrate in vacuo to dryness. Wash the residue with 1.0 M NaOH and extract with EtOAc. Consolidate the organic layer, dry with Na2SO4, filter and concentrate.![1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole synthesis route](/NewsImg/2026-03-02/6390805738354112047626930.png "1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole synthesis route")
References
[1] DANIEL WEILIANG TAY*. Palladium-meta-Terarylphosphine Catalyst for the Mizoroki–Heck Reaction of (Hetero)Aryl Bromides and Functional Olefins[J]. Journal of Organic Chemistry, 2015, 80 8: 4054-4063. DOI:10.1021/acs.joc.5b00386.
1-acetyl-3-[((2r)-1-methylpyrrolidin-2-yl)methyl]-5-[(e)-2-(phenylsulfonyl)vinyl]indole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
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| Unibest Industrial Co.,Ltd. | +86-0574-27855777 +8618758850676 | info@unibestcn.com | China | 271 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 788 | 58 |
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| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9333 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9962 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| Henan Rane Chemical Co., Ltd. | +8618738066252 | info@ranechem.com | China | 2999 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23912 | 58 |
