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2-Bromo-2-phenylacetic acid

2-Bromo-2-phenylacetic acid structure

CAS No.: 4870-65-9

Chemical Name:: 2-Bromo-2-phenylacetic acid

Synonyms: A-BROMOPHENYLACETIC ACID;(S)-2-Bromo-2-Phenylacetic Acid;DL- NSC 59241;α-BromophenyL;TIMTEC-BB SBB007654;S-2--Bromo -2-phenyl;LABOTEST-BB LT00455397;Phenylbromoacetic acid;Bromo(phenyl)acetic acid;α-Bromophenylacetic acid

CBNumber:: CB9154535

Molecular Formula:: C8H7BrO2

Molecular Weight:: 215.04

MDL Number:: MFCD00004206

MOL File:: 4870-65-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:26:37

Product description	Number	Pack Size	Price
α-Bromophenylacetic acid 98%	B75859	5g	$96.4
α-Bromophenylacetic acid 98%	B75859	25g	$367
alpha-Bromophenylacetic Acid >98.0%(GC)(T)	B0984	5g	$35
alpha-Bromophenylacetic Acid >98.0%(GC)(T)	B0984	25g	$95
2-Bromo-2-phenylaceticacid	B695755	1g	$55
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2-Bromo-2-phenylacetic acid Properties

Melting point	82-83 °C(lit.)
Boiling point	120-121 °C(Press: 0.02 Torr)
Density	1.643±0.06 g/cm3(Predicted)
storage temp.	Store below +30°C.
solubility	soluble in Methanol
pka	pK1: 2.21 (25°C)
form	powder to crystal
color	White to Almost white
InChI	1S/C8H7BrO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,(H,10,11)
InChIKey	WAKFRZBXTKUFIW-UHFFFAOYSA-N
SMILES	OC(=O)C(Br)c1ccccc1
CAS DataBase Reference	4870-65-9(CAS DataBase Reference)
NIST Chemistry Reference	«ALPHA»-bromophenylacetic acid(4870-65-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H314-H335

Precautionary statements

P260-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

34-36/37

Safety Statements

26-27-28-36/37/39-45

RIDADR

UN 3261 8/PG 2

WGK Germany

HazardClass

PackingGroup

III

HS Code

29163900

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Eye Dam. 1
Skin Corr. 1B
STOT SE 3

NFPA 704

	0
3		0

2-Bromo-2-phenylacetic acid price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B75859	α-Bromophenylacetic acid 98%	4870-65-9	5g	$96.4	2026-04-30	Buy
Sigma-Aldrich	B75859	α-Bromophenylacetic acid 98%	4870-65-9	25g	$367	2026-04-30	Buy
TCI Chemical	B0984	alpha-Bromophenylacetic Acid >98.0%(GC)(T)	4870-65-9	5g	$35	2026-04-30	Buy
TCI Chemical	B0984	alpha-Bromophenylacetic Acid >98.0%(GC)(T)	4870-65-9	25g	$95	2026-04-30	Buy
TRC	B695755	2-Bromo-2-phenylaceticacid	4870-65-9	1g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
B75859	5g	$96.4	Buy
B75859	25g	$367	Buy
B0984	5g	$35	Buy
B0984	25g	$95	Buy
B695755	1g	$55	Buy

2-Bromo-2-phenylacetic acid Chemical Properties,Uses,Production

Chemical Properties

Beige crystalline powder

Uses

α-Bromophenylacetic acid can be used as a reactant to prepare:

Polymandelide by reacting with triethylamine.
α-Mercaptophenylacetic acid by treating with sodium hydrosulfide (NaSH·H₂O).
β-Lactams by reacting with imines in the presence of triphenylphosphine as a mediator.

Uses

2-Bromo-2-phenylacetic Acid can be used as an inhibitor of mammalian collagenase and elastase.

Synthesis

103-82-2

4870-65-9

General procedure for the synthesis of α-bromophenylacetic acid from phenylacetic acid: 2-phenylacetic acid (376 mg, 2.7 mmol), N-bromosuccinimide (540 mg, 3.05 mmol), and carbon tetrachloride (5.5 mL) were added to a dry two-necked flask fitted with a condensing unit. Azobisisobutyronitrile (23 mg, 0.14 mmol) was added with stirring and the reaction was heated to reflux at 77°C with stirring for 2 hours. The progress of the reaction was monitored by nuclear magnetic resonance spectroscopy (1H NMR) until 2-phenylacetic acid was completely consumed. Upon completion of the reaction, the reaction was cooled naturally to room temperature, and the reaction mixture was diluted with hexane (10.0 mL) and filtered. The solvent was removed by rotary evaporation and purified by silica gel column chromatography (eluent: n-hexane/ether, 2:1, v/v) to afford α-bromophenylacetic acid as a white solid (95% yield).

References

[1] Patent: CN105384703, 2016, A. Location in patent: Paragraph 0014
[2] Journal of Organic Chemistry, 2016, vol. 81, # 20, p. 9620 - 9629
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 1, p. 50 - 59
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 20, p. 4333 - 4341
[5] Tetrahedron Letters, 2004, vol. 45, # 26, p. 5151 - 5154

2-Bromo-2-phenylacetic acid synthesis

Synthesis of 2-Bromo-2-phenylacetic acid from Phenylacetic acid

2-Bromo-2-phenylacetic acid Preparation Products And Raw materials

Raw materials

2,2-Oxiranedicarbonitrile, phenyl- Benzeneacetyl bromide, α-bromo- ALPHA-BROMOPHENYLACETYL CHLORIDE BROMOCHLOROACETIC ACID 1,1-Dibromo-2-phenylethene

2-Amino-2-phenylacetic acid Benzaldehyde ISOPROPYLMAGNESIUM BROMIDE Sodium phenylacetate Phenylacetic acid

Benzoic acid Benzene (S)-(+)-Mandelic acid

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Preparation Products

DL-alpha-Methoxyphenylacetic acid tert-butyl 2-bromo-2-phenylacetate Benzeneacetic acid, α-(acetylthio)-

2-Bromo-2-phenylacetic acid Suppliers

Global( 232)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3590	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+15184799099	lbaochemicals@gmail.com	China	671	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Unipharm pharmaceutical industry Co., Ltd	536-8266195 +8613953676784	lee@unipharm-sd.com	China	1202	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Henan Alfa Chemical Co., Ltd	+8615838112936	sale03@alfachem.cn	China	9659	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Unipharm pharmaceutical industry Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58

View Lastest Price from 2-Bromo-2-phenylacetic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-29	2-Bromo-2-phenylacetic acid 4870-65-9	US $0.00 / kg	1kg	98%	Customise	Hefei Lbao Physical & Chemical Science Co.,Ltd
2025-12-12	2-Bromo-2-phenylacetic acid 4870-65-9	US $30.00-20.00 / KG	1KG	99%	200000KG	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	2-Bromo-2-phenylacetic acid 4870-65-9	US $1.00 / KG	1KG	99%	100	Career Henan Chemical Co

2-Bromo-2-phenylacetic acid
4870-65-9
US $0.00 / kg
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

2-Bromo-2-phenylacetic acid
4870-65-9
US $30.00-20.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

2-Bromo-2-phenylacetic acid
4870-65-9
US $1.00 / KG
99%
Career Henan Chemical Co

2-Bromo-2-phenylacetic acid Spectrum

2-Bromo-2-phenylacetic acid(4870-65-9)MS 2-Bromo-2-phenylacetic acid(4870-65-9)¹HNMR 2-Bromo-2-phenylacetic acid(4870-65-9)¹³CNMR 2-Bromo-2-phenylacetic acid(4870-65-9)IR1 2-Bromo-2-phenylacetic acid(4870-65-9)IR2 2-Bromo-2-phenylacetic acid(4870-65-9)Raman

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Benzeneacetic acid, alpha-bromo- Bromo(phenyl)acetic acid TIMTEC-BB SBB007654 DL-ALPHA-BROMOPHENYLACETIC ACID LABOTEST-BB LT00455397 2-BROMO-2-PHENYLACETIC ACID ALPHA-BROMOPHENYLACETIC ACID A-BROMOPHENYLACETIC ACID (2S)-2-bromo-2-cyclohexylacetate DL-α-Bromophenylacetic acid for synthesis (RS)-2-broMo-2-phenyl-acetic acid DL- NSC 59241 alpha-Bromophenylacetic acid 98% DL-α-Bromophenylacetic acid (S)-2-Bromo-2-Phenylacetic Acid ALPHA-BROMO-ALPHA-PHENYLACETIC ACID a-Bromophenylacetic acid, Pract. a-Bromo-a-phenylacetic acid a-Bromobenzeneacetic acid DL-a-Bromophenylacetic acid Phenylbromoacetic acid α-Bromobenzeneacetic acid DL-alpha-Bromophenylacetic acid,99.5% S-2--Bromo -2-phenyl α-BromophenylaceticAcid> α-BromophenyL Benzeneacetic acid, α-bromo- α-Bromophenylacetic acid 2-Bromo-2-PhenylaceticAci Aprocitentan Impurity 65 4870-65-9 C6H5CHBrCO2H CARBOXYLIC ACID C8 Carboxylic Acids Carbonyl Compounds Building Blocks Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acids Chemical Synthesis Organic Building Blocks C8 Carbonyl Compounds Carboxylic Acids Pharmaceutical Intermediates