4-Fluoro-2-methylaniline
- CAS No.
- 452-71-1
- Chemical Name:
- 4-Fluoro-2-methylaniline
- Synonyms
- 2-AMINO-5-FLUOROTOLUENE;4-Fluoro-2-methylbenzenamine;4-fluorotoluidine;4-FLUORO-O-TOLUIDINE;2-Fluoro-o-toluidine;4-Fluoro-2-methylani;o-Toluidine, 4-fluoro-;6-Amino-3-fluorotoluene;3-FLUORO-6-AMINOTOLUENE;2-Methyl-4-fluoroaniline
- CBNumber:
- CB9159888
- Molecular Formula:
- C7H8FN
- Molecular Weight:
- 125.14
- MDL Number:
- MFCD00007832
- MOL File:
- 452-71-1.mol
- MSDS File:
- SDS
| Melting point | 14.2°C |
|---|---|
| Boiling point | 90-92 °C/16 mmHg (lit.) |
| Density | 1.126 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 190 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| pka | 4.51±0.10(Predicted) |
| form | clear liquid |
| color | Light yellow to Yellow to Orange |
| Specific Gravity | 1.126 |
| BRN | 1931798 |
| CAS DataBase Reference | 452-71-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | P7D3BF9SJM |
| NIST Chemistry Reference | Benzenamine, 4-fluoro-2-methyl-(452-71-1) |
| EPA Substance Registry System | 4-Fluoro-2-methylaniline (452-71-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-23/24/25 | |||||||||
| Safety Statements | 26-36/37/39-45-36 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CY0500000 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| TSCA | T | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214300 | |||||||||
| NFPA 704 |
|
4-Fluoro-2-methylaniline price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 189243 | 4-Fluoro-2-methylaniline 96% | 452-71-1 | 5g | $37 | 2023-06-20 | Buy |
| Sigma-Aldrich | 189243 | 4-Fluoro-2-methylaniline 96% | 452-71-1 | 25g | $76.3 | 2023-01-07 | Buy |
| TCI Chemical | F0398 | 4-Fluoro-2-methylaniline >98.0%(GC)(T) | 452-71-1 | 5g | $36 | 2025-07-31 | Buy |
| TCI Chemical | F0398 | 4-Fluoro-2-methylaniline >98.0%(GC)(T) | 452-71-1 | 25g | $102 | 2025-07-31 | Buy |
| TRC | F593065 | 4-Fluoro-2-methylaniline | 452-71-1 | 25g | $105 | 2021-12-16 | Buy |
4-Fluoro-2-methylaniline Chemical Properties,Uses,Production
Chemical Properties
colorlesstolightyellowliqui
Uses
4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline.
Synthesis
446-33-3
452-71-1
General procedure for the synthesis of 4-fluoro-2-methylaniline from 5-fluoro-2-nitrotoluene: 10% palladium/carbon (Pd/C, 21 mg, 0.020 mmol) was added to a solution of 4-fluoro-2-methyl-1-nitrobenzene (3b, 243 mL, 2.00 mmol) in methanol (MeOH, 10 mL). The reaction mixture was stirred at room temperature and bubbled with hydrogen (H2) for 2 hours. Upon completion of the reaction, the solid catalyst was removed by filtration and the solids were washed with dichloromethane (DCM, 25 mL). The filtrate and DCM wash solution were combined and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, petroleum ether (P.E.) gradient elution to petroleum ether:ethyl acetate (PE:EtOAc) 4:1) to afford 4-fluoro-2-methylaniline (4b) as a pink oil (250 mg, 100% yield).
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 539 - 550
[2] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[3] Synlett, 2007, # 16, p. 2557 - 2558
[4] Acta Chemica Scandinavica (1947-1973), 1955, vol. 9, p. 1079,1083
[5] Chemische Berichte, 1929, vol. 62, p. 1804
4-Fluoro-2-methylaniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12580 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1382 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
View Lastest Price from 4-Fluoro-2-methylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | 4-Fluoro-2-methylaniline
452-71-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-07-25 | 4-Fluoro-2-methylaniline
452-71-1
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-27 | 4-Fluoro-2-methylaniline
452-71-1
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Fluoro-2-methylaniline
452-71-1
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 4-Fluoro-2-methylaniline
452-71-1
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Fluoro-2-methylaniline
452-71-1
- US $0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
