Benzyloxyacetyl chloride
- CAS No.
- 19810-31-2
- Chemical Name:
- Benzyloxyacetyl chloride
- Synonyms
- 2-(Benzyloxy)acetyl chloride;oxyacetyL;BENZYLOXYACETYL CHLORIDE;Benzyloxyacetyl chloride 95%;Benzyloxyacetyl chloride ,95%;Benzyloxyacetic acid chloride;(Benzyloxy)acetic acid chloride;2-(Phenylmethoxy)-acetyl chloride;2-(Benzyloxy)acetic acid chloride;Acetyl chloride, 2-(phenylMethoxy)-
- CBNumber:
- CB9167296
- Molecular Formula:
- C9H9ClO2
- Molecular Weight:
- 184.62
- MDL Number:
- MFCD00010768
- MOL File:
- 19810-31-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Benzyloxyacetyl chloride 95% | 301019 | 5g | $58.38 |
| Benzyloxyacetyl chloride 95% | 301019 | 25g | $309 |
| 2-(Benzyloxy)acetyl Chloride min. 98.0 % | B3665 | 5G | $83 |
| 2-(Benzyloxy)acetyl Chloride min. 98.0 % | B3665 | 25G | $249 |
| 2-(Benzyloxy)acetylChloride | B130515 | 100mg | $75 |
| More product size | |||
| Melting point | 120 °C (decomp) |
|---|---|
| Boiling point | 84-87 °C/0.4 mmHg (lit.) |
| Density | 1.17 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| form | Powder or Cyrstals |
| color | White |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 1947363 |
| InChI | InChI=1S/C9H9ClO2/c10-9(11)7-12-6-8-4-2-1-3-5-8/h1-5H,6-7H2 |
| InChIKey | QISAUDWTBBNJIR-UHFFFAOYSA-N |
| SMILES | C(Cl)(COCC1=CC=CC=C1)=O |
| CAS DataBase Reference | 19810-31-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 14-34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Benzyloxyacetyl chloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 301019 | Benzyloxyacetyl chloride 95% | 19810-31-2 | 5g | $58.38 | 2025-07-31 | Buy |
| Sigma-Aldrich | 301019 | Benzyloxyacetyl chloride 95% | 19810-31-2 | 25g | $309 | 2025-07-31 | Buy |
| TCI Chemical | B3665 | 2-(Benzyloxy)acetyl Chloride min. 98.0 % | 19810-31-2 | 5G | $83 | 2025-07-31 | Buy |
| TCI Chemical | B3665 | 2-(Benzyloxy)acetyl Chloride min. 98.0 % | 19810-31-2 | 25G | $249 | 2025-07-31 | Buy |
| TRC | B130515 | 2-(Benzyloxy)acetylChloride | 19810-31-2 | 100mg | $75 | 2021-12-16 | Buy |
Benzyloxyacetyl chloride Chemical Properties,Uses,Production
Chemical Properties
Colorless to yellow liquid
Uses
Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.
Uses
Commonly employed reagent for asymmetric synthesis of β-lactams.1,2
Synthesis
30379-55-6
19810-31-2
Example 1 (a) Synthesis of benzyloxyacetyl chloride: to a solution of dichloromethane (50 mL) containing benzyloxyacetic acid (10.0 g, 60.0 mmol, 8.6 mL) was sequentially added oxalyl chloride (9.1 g, 72.0 mmol, 6.0 mL) and N,N-dimethylformamide (DMF, 30.0 mg, 0.4 mmol, 32.0 μL). The reaction mixture was stirred for 3 h at room temperature. Rapid gas release was observed at the beginning of the reaction, which gradually stopped as the reaction progressed. Upon completion of the reaction, the dichloromethane solution was concentrated under reduced pressure to give a colloidal product. Subsequently, additional oxalyl chloride (4.5 g, 35.7 mmol, 3.0 mL), dichloromethane (50 mL), and a drop of DMF were added to the gelatinous product, and the reaction mixture was again stirred for 2 h, during which a rapid gas release was observed. Finally, the reaction mixture was concentrated under reduced pressure to afford benzyloxyacetyl chloride (1) 11.0 g (in quantitative yield) as a gel. The structure of the product was confirmed by 13C NMR (75 MHz, CDCl3) with chemical shifts of δ 73.6, 74.8, 128.1, 128.4, 128.6, 130.0 and 171.9.
References
[1] Patent: US2013/177501, 2013, A1. Location in patent: Paragraph 0152
[2] Patent: WO2015/7834, 2015, A1. Location in patent: Page/Page column 17
[3] Patent: WO2015/40087, 2015, A1. Location in patent: Page/Page column 13; 14
[4] Patent: US9168317, 2015, B2. Location in patent: Page/Page column 20
[5] Patent: US9314541, 2016, B2. Location in patent: Page/Page column 21
Benzyloxyacetyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Shandong Liteng Biotechnology Co. , Ltd. | +86-18663721413 +86-15552573001 | rosy@litengpharm.com | China | 3282 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from Benzyloxyacetyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | Benzyloxyacetyl chloride
9810-31-2
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co | |
 |
2019-12-24 | Benzyloxyacetyl chloride
9810-31-2
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co | |
 |
2019-07-06 | Benzyloxyacetyl chloride
19810-31-2
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- Benzyloxyacetyl chloride
9810-31-2
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co
-
- Benzyloxyacetyl chloride
9810-31-2
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co
-
- Benzyloxyacetyl chloride
19810-31-2
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
