3-(difluoromethoxy)pyridin-2-amine
- CAS No.
- 947249-14-1
- Chemical Name:
- 3-(difluoromethoxy)pyridin-2-amine
- Synonyms
- 3-(difluoromethoxy)pyridin-2-amine;3-(Difluoromethoxy)-2-pyridinamine;2-Amino-3-(difluoromethoxy)pyridine;2-Pyridinamine, 3-(difluoromethoxy)-
- CBNumber:
- CB91704564
- Molecular Formula:
- C6H6F2N2O
- Molecular Weight:
- 160.12
- MDL Number:
- MFCD12405788
- MOL File:
- 947249-14-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P305+P351+P338 |
| HS Code | 2933399990 |
3-(difluoromethoxy)pyridin-2-amine price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XMB24914 | 3-(Difluoromethoxy)pyridin-2-amine | 947249-14-1 | 2.5g | $383.5 | 2026-06-05 | Buy |
| Apolloscientific | PC448010 | 3-(Difluoromethoxy)pyridin-2-amine 95% | 947249-14-1 | 250mg | $45 | 2026-06-04 | Buy |
| Apolloscientific | PC448010 | 3-(Difluoromethoxy)pyridin-2-amine 95% | 947249-14-1 | 1g | $116 | 2026-06-04 | Buy |
| Activate Scientific | AS29766 | 2-Amino-3-(difluoromethoxy)pyridine 95% | 947249-14-1 | 1g | $296 | 2026-06-04 | Buy |
| Activate Scientific | AS29766 | 2-Amino-3-(difluoromethoxy)pyridine 95% | 947249-14-1 | 5g | $1010 | 2026-06-04 | Buy |
3-(difluoromethoxy)pyridin-2-amine Chemical Properties, Uses, Production
Synthesis
1111637-77-4
947249-14-1
General procedure for the synthesis of 3-(difluoromethoxy)pyridin-2-amine from 3-(difluoromethoxy)-2-nitropyridine: 3-(difluoromethoxy)-2-nitropyridine (450 mg, 2.37 mmol) was dissolved in a mixed solvent of ethanol (2 mL) and acetic acid (2 mL) and reduced iron powder (397 mg, 7.10 mmol) was added. The reaction mixture was stirred at 100 °C overnight. Since the ingredients were not fully reacted, reduced iron powder (397 mg, 7.10 mmol) was added again and stirring was continued at 100 °C overnight. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. To the concentrated residue was added saturated aqueous sodium bicarbonate and extracted three times with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and purified by silica gel column chromatography (eluent: chloroform/methanol=9/1, v/v) to afford the target product 3-(difluoromethoxy)pyridin-2-amine (250 mg, 66% yield). The product was detected by electrospray ionization mass spectrometry (ESIMS), m/z: 161 (M + H)+; 1H NMR (270 MHz, CDCl3, δ): 4.79 (broad single peak, 2H), 6.14-6.80 (multiple peaks, 2H), 7.19-7.35 (multiple peaks, 1H), 7.85-7.98 (multiple peaks, 1H).
References
[1] Patent: WO2010/100127, 2010, A1. Location in patent: Page/Page column 73
[2] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 55-56
[3] Patent: EP2740730, 2014, A1. Location in patent: Paragraph 0346
[4] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 108
[5] Patent: WO2015/91889, 2015, A1. Location in patent: Page/Page column 73; 74
3-(difluoromethoxy)pyridin-2-amine Preparation Products And Raw materials
3-(difluoromethoxy)pyridin-2-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD | 571-89189769 15168342188 | China | 228 | 62 | |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| skychemical Co.Ltd | 021-20960837,QQ1332204249 | sales@skychemical.com | China | 3338 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
