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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Structure
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid structure
CAS No.
17257-71-5
Chemical Name:
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
Synonyms
(-)-MTPA;(S)-(-)-MPTA;MOSHERS ACID;(-)-MOSHER'S ACID;(S)-(-)-Mosheracid;(S)-(-)-MOSHER'S ACID;(-)-MTPA, Moshers acid;(-)-Moshers acid~(-)-MTPA;(S)-(-)-MTPA,(S)-(-)-Mosher'sacid;(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
CBNumber:
CB9171585
Molecular Formula:
C10H9F3O3
Molecular Weight:
234.17
MDL Number:
MFCD00064200
MOL File:
17257-71-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:57:00
Product description Number Pack Size Price
(S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% 318035 250mg $87.9
(S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% 318035 1g $187
(S)-(−)-α-Methoxy-α-trifluoromethylphenylacetic acid for chiral derivatization, LiChropur?, ≥99.0% 65369 250mg $162
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) M0832 1g $182
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) M0832 5g $674
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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Properties

Melting point 46-49 °C(lit.)
alpha D24 -71.8± 0.6° (c = 3.28 in CH3OH)
Boiling point 95-97 °C0.05 mm Hg(lit.)
Density 1.303 g/mL at 25 °C(lit.)
refractive index n20/D 1.474(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility Readily soluble in hexane, ether, THF, CH2Cl2, benzene.
pka 1.47±0.10(Predicted)
form Viscous Liquid or Low Melting Solid
color Clear colorless or white
Specific Gravity 1.303
optical activity [α]20/D 73±1°, c = 2% in methanol
Sensitive Hygroscopic
Merck 14,6280
BRN 3591561
InChI 1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m0/s1
InChIKey JJYKJUXBWFATTE-VIFPVBQESA-N
SMILES CO[C@](C(O)=O)(c1ccccc1)C(F)(F)F
CAS DataBase Reference 17257-71-5(CAS DataBase Reference)
FDA UNII 172HCJ1IQV
UNSPSC Code 12352112
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
F  3-10
Hazard Note  Irritant/Keep Cold
HazardClass  IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code  29189900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 318035 (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% 17257-71-5 250mg $87.9 2026-04-30 Buy
Sigma-Aldrich 318035 (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% 17257-71-5 1g $187 2026-04-30 Buy
Sigma-Aldrich 65369 (S)-(−)-α-Methoxy-α-trifluoromethylphenylacetic acid for chiral derivatization, LiChropur?, ≥99.0% 17257-71-5 250mg $162 2022-05-15 Buy
TCI Chemical M0832 (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) 17257-71-5 1g $182 2026-04-30 Buy
TCI Chemical M0832 (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) 17257-71-5 5g $674 2026-04-30 Buy
Product number Packaging Price Buy
318035 250mg $87.9 Buy
318035 1g $187 Buy
65369 250mg $162 Buy
M0832 1g $182 Buy
M0832 5g $674 Buy

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Chemical Properties,Uses,Production

Chemical Properties

clear colorless viscous liquid

Uses

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.

General Description

(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.

Purification Methods

A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Suppliers

Global( 166)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30227 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49968 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Career Henan Chemica Co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
GIHI CHEMICALS CO.,LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58

View Lastest Price from (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99% pictures 2021-07-02 (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99%
17257-71-5
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Spectrum

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)1HNMR(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)IR(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)FT-IR(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid(17257-71-5)Raman

17257-71-5((S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid)Related Search:

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α-Lipoic Acid Ascoric Acid (S)-(+)-2-METHOXY-2-PHENYLETHANOL 3,3,3-TRIFLUOROLACTIC ACID (S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID
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(S)-(-)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99% (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving] (-)-MTPA, Moshers acid (S)-(-)-Mosheracid (S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid [S,(-)]-3,3,3-Trifluoro-2-methoxy-2-phenylpropionic acid [S,(-)]-α-Trifluoromethyl-α-methoxyphenylacetic acid [S,(-)]-β,β,β-Trifluoro-α-methoxyhydratropic acid (S)-()-α-Methoxy-α-trifluoromethylphenylacetic acid,()-MTPA, Mosher’s acid (2S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99% (99%ee) (S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid (S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic Acid  (S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid, 98% 250MG (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid,98% (S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid >=99% (2S)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99% minus-A-methoxy-A-trifluoro-methyl*phenylacetic A (S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL) PH ENYLACETIC ACID, 99+% (99% EE/GLC) MINUS-A-METHOXY-A-TRIFLUORO-METHYL*PHENY LACETIC ACI (S)-(-)-A-METHOXY-A-(TRIFLUORO-ME-)-PH-A CETIC ACID, CHIRASELECT REAG (99+%EE) (S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee) (S)-(-)-MTPA,(S)-(-)-Mosher'sacid Benzeneacetic acid, .alpha.-methoxy-.alpha.-(trifluoromethyl)-, (.alpha.S)- (s)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetic acid (S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee) (S)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee) (-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID (-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID (S)-(-)-MOSHER'S ACID (S)-(-)-MPTA (S)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID (S)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID (S)-(-)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID (S)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID (-)-MOSHER'S ACID MOSHERS ACID (-)-MTPA (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid (-)-Moshers acid~(-)-MTPA (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylaceticAcid[OpticalResolving]> Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-, (αS)- (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic ac (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] (S)-(?)-α-Methoxy-α-trifluoromethylphenylacetic acid (S)-(–)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, CAS 17257-71-5 (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid (2S)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid (2S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propanoic acid - [T83613] 17257-71-5 Asymmetric Synthesis Derivatization Reagents Chiral Resolving Reagents Chiral Resolution Reagents Analytical Chromatography Product Catalog Chiral Derivatization