ETYA
- CAS No.
- 1191-85-1
- Chemical Name:
- ETYA
- Synonyms
- EICOSATETRAYNOIC ACID;ETYA;Ro-3-1428;Dry Arachidonic Acid CWS;MGLDCXPLYOWQRP-UHFFFAOYSA-N;OCTADEHYDROARACHIDONIC ACID;Eicosatetraynoic acid(ETYA);5,8,11,14-Icosatetrynoic acid;Arachidonic Acid(A&A) 10% CWS;5,8,11,14-EICOSATETRANOIC ACID
- CBNumber:
- CB9177956
- Molecular Formula:
- C20H24O2
- Molecular Weight:
- 296.4
- MDL Number:
- MFCD00036967
- MOL File:
- 1191-85-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5,8,11,14-Eicosatetraynoic acid ≥97% | E1768 | 5mg | $336 |
| ETYA | 434741 | 20mg | $366 |
| 5,8,11,14-Eicosatetraynoic Acid ≥98% | 90120 | 5mg | $59 |
| 5,8,11,14-Eicosatetraynoic Acid ≥98% | 90120 | 10mg | $106 |
| 5,8,11,14-Eicosatetraynoic Acid ≥98% | 90120 | 25mg | $250 |
| Melting point | 79-81 °C |
|---|---|
| Boiling point | 490.3±45.0 °C(Predicted) |
| Density | 1.034±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ≤10mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide |
| form | Off-white solid |
| pka | 4.61±0.10(Predicted) |
| color | Light yellow to brown |
| biological source | synthetic (organic) |
| BRN | 1798411 |
| InChI | 1S/C20H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14,17-19H2,1H3,(H,21,22) |
| InChIKey | MGLDCXPLYOWQRP-UHFFFAOYSA-N |
| SMILES | CCCCCC#CCC#CCC#CCC#CCCCC(O)=O |
| FDA UNII | 5FEJ8J06DR |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
ETYA price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1768 | 5,8,11,14-Eicosatetraynoic acid ≥97% | 1191-85-1 | 5mg | $336 | 2026-04-30 | Buy |
| Sigma-Aldrich | 434741 | ETYA | 1191-85-1 | 20mg | $366 | 2026-04-30 | Buy |
| Cayman Chemical | 90120 | 5,8,11,14-Eicosatetraynoic Acid ≥98% | 1191-85-1 | 5mg | $59 | 2026-04-30 | Buy |
| Cayman Chemical | 90120 | 5,8,11,14-Eicosatetraynoic Acid ≥98% | 1191-85-1 | 10mg | $106 | 2026-04-30 | Buy |
| Cayman Chemical | 90120 | 5,8,11,14-Eicosatetraynoic Acid ≥98% | 1191-85-1 | 25mg | $250 | 2026-04-30 | Buy |
ETYA Chemical Properties,Uses,Production
Uses
ETYA is a Cox, LO, and PLA2 inhibitor.
Definition
ChEBI: Eicosa-5,8,11,14-tetraynoic acid is a long-chain fatty acid.
Biological Activity
eicosatetraynoic acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1].cyclooxygenase (cox) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. two cyclooxygenase isoforms have been identified: cox-1 and cox-2. the cox-1 enzyme is produced constitutively (i.e., gastric mucosa) and cox-2 is inducible (i.e., sites of inflammation). cyclooxygenase has been involved in different physiological situations and disease processes ranging from inflammation to cancer [2]. lipoxygenases belong to a family of non-heme and iron-containing enzymes and serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells [3].in human platelet, eicosatetraynoic acid inhibited 12-lo and cox-1 with ic50 values of 4 μm and 8 μm, respectively [1]. eicosatetraynoic acid acted as a ppar ligand which activated pparα and pparγ chimeras at concentrations of 10 μm [4].
Biochem/physiol Actions
Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of ω-6 arachidonic acid.ETYA is a strong activator of the human peroxisome proliferator-activated receptor α (PPARα). It acts as an inhibitor of lipoxygenases (LOX) and cyclooxygenases (COX).
IC 50
COX: 8 μM (ID50)
References
[1] hammarstrm s. selective inhibition of platelet n—8 lipoxygenase by 5, 8, 11-eicosatriynoic acid[j]. biochimica et biophysica acta (bba)-lipids and lipid metabolism, 1977, 487(3): 517-519.
[2] dubois r n, abramson s b, crofford l, et al. cyclooxygenase in biology and disease[j]. the faseb journal, 1998, 12(12): 1063-1073.
[3] feussner i, wasternack c. the lipoxygenase pathway[j]. annual review of plant biology, 2002, 53(1): 275-297.
[4] kliewer s a, lenhard j m, willson t m, et al. a prostaglandin j2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation[j]. cell, 1995, 83(5): 813-819.
ETYA Preparation Products And Raw materials
ETYA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2208 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12984 | 57 |
View Lastest Price from ETYA manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Eicosatetraynoic acid
1191-85-1
|
$192.00-823.00 | 10g | TargetMol Chemicals Inc. |
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- Eicosatetraynoic acid
1191-85-1
- $192.00-823.00
- TargetMol Chemicals Inc.
