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Liensinine

Liensinine Structure
Liensinine structure
CAS No.
2586-96-1
Chemical Name:
Liensinine
Synonyms
Hiensinine;LIENSININE;Liensinine USP/EP/BP;Liensinine perchlorafe;Phenol,4-[[(1R)-1,2,3,4-tetrahydro-6, 7-dimethoxy-;2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-(((R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol;4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol;Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-
CBNumber:
CB9179455
Molecular Formula:
C37H42N2O6
Molecular Weight:
610.74
MDL Number:
MFCD03427702
MOL File:
2586-96-1.mol
MSDS File:
SDS
Last updated:2025-10-22 08:34:43
Product description Number Pack Size Price
Liensinine L0432 10MG $208
Liensinine L397833 10mg $175
Liensinine FL65625 25mg $175
Liensinine FL65625 5mg $50
Liensinine FL65625 10mg $80
More product size
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Liensinine Properties

Melting point 95-99 °C
Boiling point 722.0±60.0 °C(Predicted)
Density 1.218±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility Acetone (Slightly), Chloroform (Slightly)
form Solid
pka 9.28±0.45(Predicted)
color White to Off-White
InChIKey XCUCMLUTCAKSOZ-FIRIVFDPSA-N
SMILES C1(O)=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC1=CC=C(O)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501

Liensinine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical L0432 Liensinine 2586-96-1 10MG $208 2025-07-31 Buy
TRC L397833 Liensinine 2586-96-1 10mg $175 2021-12-16 Buy
Biosynth Carbosynth FL65625 Liensinine 2586-96-1 25mg $175 2021-12-16 Buy
Biosynth Carbosynth FL65625 Liensinine 2586-96-1 5mg $50 2021-12-16 Buy
Biosynth Carbosynth FL65625 Liensinine 2586-96-1 10mg $80 2021-12-16 Buy
Product number Packaging Price Buy
L0432 10MG $208 Buy
L397833 10mg $175 Buy
FL65625 25mg $175 Buy
FL65625 5mg $50 Buy
FL65625 10mg $80 Buy

Liensinine Chemical Properties,Uses,Production

Description

The isomer of isoliensinine (q.v.), this alkaloid is present in the embryo of the seeds of Nelumbo nucifera Gaertn.

Uses

Liensinine is a bisbenzylisoquinoline alkaloid with inhibitory properties towards the activation of microglial cells. In testing with rats, iensinine decreased epileptic discharges were observed on electrocorticograms.

Definition

ChEBI: Liensinine is a member of isoquinolines.

in vivo

Liensinine (oral gavage, 100 or 200 mg/kg, daily, 10 weeks) can effectively treat periodontitis, similar to metronidazole-type drugs, and has a certain dose-dependent[2].

Animal Model:KM mice[2]
Dosage:100 mg/kg, 200 mg/kg
Administration:oral gavage, daily, 10 weeks
Result:Reduced the gingival index and increased the SOD levels, the CAT, GSH-Px levels and decreased the NO, MDA, and ET levels compared to the control group.
Animal Model:Institute of Cancer Research (ICR) mice (male, 20-22 g)[3]
Dosage:
Administration:5 mg/kg by oral administration; 1 mg/kg by intravenous administration
Result:The pharmacokinetic parameters of Liensinine in mice
Parameterspo (5 mg/kg)iv (1 mg/kg)
AUC(0-t) (ng/mL*h)18.8 ± 2.7211.2 ± 54.9
AUC(0-∞) (ng/mL*h)19.1 ± 2.8227.9 ± 60.1
MRT(0-t)( h)3.2 ± 0.42.6 ± 0.5
MRT(0-∞) (h)3.4 ± 0.53.5 ± 0.9
t1/2z (h)1.9 ± 0.23.8 ± 0.8
CLz/F (L/h/kg)266.0 ± 41.34.7 ± 1.2
Vz/F (L/kg)708.5 ± 79.925.9 ± 11.0
Cmax (ng/mL)5.3 ± 0.2169.5 ± 53.5

References

Tse-yuan et al., Sci. Sinica., 11, 215 (1962)
Pei-chuanetal., ibid, 11,321 (1962)

Liensinine Preparation Products And Raw materials

Raw materials

Preparation Products

Liensinine Suppliers

Global( 227)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 3751 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Shanghai Standard Technology Co., Ltd. 		18502101150 ft-sales@nature-standard.com CHINA 1923 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29799 58
Supplier Advantage
Shaanxi Haibo Biotechnology Co., Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
Chengdu GLP biotechnology Co Ltd 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
Shanghai Standard Technology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58

View Lastest Price from Liensinine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Liensinine pictures 2025-10-22 Liensinine
2586-96-1
 US $47.00-163.00 / mg 99.56% 10g TargetMol Chemicals Inc.
Liensinine pictures 2024-04-12 Liensinine
2586-96-1
 US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Liensinine pictures 2023-04-04 Liensinine
US $10.00 / KG 1KG 5% 100KG Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
  • Liensinine pictures
  • Liensinine
    2586-96-1
  • US $47.00-163.00 / mg
  • 99.56%
  • TargetMol Chemicals Inc.
  • Liensinine pictures
  • Liensinine
    2586-96-1
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
  • Liensinine pictures
  • Liensinine
  • US $10.00 / KG
  • 5%
  • Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.

Liensinine Spectrum

Liensinine(2586-96-1)MS

2586-96-1(Liensinine)Related Search:

ELEUTHEROSIDE A Sophoridine Dihydromyrcenol Basic Violet 1 Kresoxim-methyl
Methyl acrylate Acetonitrile Methylparaben Paraquat dichloride Methanol
Methyl Liensinine perchlorate Isoliensinine Neferine Liensinine HClO 4
Nefrine perchlorate Liensinine Dimethoxy

1of4

4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol LIENSININE Hiensinine Liensinine 4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol 2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]- Phenol,4-[[(1R)-1,2,3,4-tetrahydro-6, 7-dimethoxy- 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol Liensinine perchlorafe Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]- Liensinine USP/EP/BP 4-(((R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol 2586-96-1 Alkaloids chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract