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Profenofos

Profenofos structure

CAS No.: 41198-08-7

Chemical Name:: Profenofos

Synonyms: PROFENOPHOS;PROFENFOS;CURACRON;PROFENPHOS;O-(4-BROMO-2-CHLOROPHENYL)-O-ETHYL-S-PROPYL PHOSPHOROTHIOATE;TaMbo;PRAHAR;Calofos;Prowess;SANOFOS

CBNumber:: CB9184781

Molecular Formula:: C11H15BrClO3PS

Molecular Weight:: 373.63

MDL Number:: MFCD00078736

MOL File:: 41198-08-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:23:10

Product description	Number	Pack Size	Price
Profenofos PESTANAL	45632	250mg	$145
Profenofos	TRC-P755880-1G	1g	$199
Profenofos	TRC-P755880-10G	10g	$1464
Profenofos	FP27172	50mg	$900
Profenofos	FP27172	500mg	$900
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Profenofos Properties

Melting point	<25 °C
Boiling point	110°C (0.001 torr)
Density	d20 1.455
vapor pressure	1.24×10^-4 Pa (25 °C)
refractive index	n20D 1.5466
Flash point	124℃
storage temp.	APPROX 4°C
solubility	DMSO: 50 mg/mL (133.82 mM)
Water Solubility	28 mg l^-1 (25 °C)
form	Oily Liquid
Specific Gravity	1.455 (20℃)
color	Colorless to light yellow
Merck	13,7860
BRN	2150258
Henry's Law Constant	4.5×10² mol/(m³Pa) at 25℃, HSDB (2015)
Major Application	agriculture environmental
InChI	1S/C11H15BrClO3PS/c1-3-7-18-17(14,15-4-2)16-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3
InChIKey	QYMMJNLHFKGANY-UHFFFAOYSA-N
SMILES	CCCSP(=O)(OCC)Oc1ccc(Br)cc1Cl
LogP	4.2 at 25℃
CAS DataBase Reference	41198-08-7(CAS DataBase Reference)
FDA UNII	7J04O7BS4W
NIST Chemistry Reference	Phosphorothioic acid, o-(4-bromo-2-chlorophenyl) o-ethyl s-propyl ester(41198-08-7)
EPA Substance Registry System	Profenofos (41198-08-7)
Pesticides Freedom of Information Act (FOIA)	Profenofos
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302+H312+H332-H317-H410
Precautionary statements	P261-P273-P280-P301+P312-P302+P352+P312-P304+P340+P312
PPE	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes	Xn,N,T
Risk Statements	20/21/22-50/53-24-20/22-43
Safety Statements	36/37-60-61-45-9-7
RIDADR	3018
WGK Germany	3
RTECS	TE6975000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29309090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Skin Sens. 1
Hazardous Substances Data	41198-08-7(Hazardous Substances Data)
Toxicity	LD50 in rat (mg/kg): 358-400 orally; ~3300 dermally; LC50 (4 hr) in rat (mg/m3): ~3000 by inhalation (Buholzer); LC50 (96 hr) in rainbow fish: 0.91 mg/l (Kumar, Chapman).
REACH Registrations	Inactive

Profenofos price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	45632	Profenofos PESTANAL	41198-08-7	250mg	$145	2026-04-30	Buy
TRC	TRC-P755880-1G	Profenofos	41198-08-7	1g	$199	2026-06-03	Buy
TRC	TRC-P755880-10G	Profenofos	41198-08-7	10g	$1464	2026-06-03	Buy
Biosynth	FP27172	Profenofos	41198-08-7	50mg	$900	2026-06-04	Buy
Biosynth	FP27172	Profenofos	41198-08-7	500mg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
45632	250mg	$145	Buy
TRC-P755880-1G	1g	$199	Buy
TRC-P755880-10G	10g	$1464	Buy
FP27172	50mg	$900	Buy
FP27172	500mg	$900	Buy

Profenofos Chemical Properties,Uses,Production

Description

Profenofos is a pale yellow liquid, bp 100 C/1.80 Pa, vp 0.124 mPa (25 C). Solubility in water is 28 mg/L (25 C). It is miscible with most organic solvents. Log Kow = 4.44. It is relatively stable in neutral and mild acid media but hydrolyzed in alkaline media; DT₅₀ values (20 C) at pH 5, 7, and 9 are 93 d, 14.6 d, and 5.7 h, respectively.

Chemical Properties

Profenofos is a pale yellow liquid. Profenofos is relatively stable under neutral and slightly acidic conditions and unstable under alkaline conditions.Profenofos has a garlic-like odor.
Profenofos has limited solubility in water (28 mg/L at 25°C) but is completely soluble in organic solvents (ethanol, acetone, toluene, n-octanol and n-hexane) at 25°C.

Uses

A broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control.

Uses

Insecticide; acaricide.

Uses

Profenofos is used to control insects (particularly caterpillars and Lepidoptera eggs) and mites on cotton, maize, sugar beet, soyabean, potatoes, vegetables, tobacco and a number of other crops

Definition

ChEBI: Profenofos is an organic thiophosphate, an organophosphate insecticide, an organochlorine insecticide and a member of monochlorobenzenes. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a 4-bromo-2-chlorophenol.

General Description

Pale yellow liquid with garlic-like odor. Corrosive. Used as an insecticide.

Air & Water Reactions

Hydrolyzed under alkaline conditions.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Agricultural Uses

Profenofos: Profenofos is A U.S. EPA restricted Use Pesticide (RUP) used solely on cotton to control a number of pests including tobacco budworm, cotton aphid and bollworm, armyworm, fleahopper and whiteflies. It is not registered for residential use. Not approved for use in EU countries. Registered for use in the U.S.

Trade name

CGA-15324®; CURACRON®; POLYCRON®; SELECRON®

Synthesis

The commercial production of profenofos involves synthesis through a chemical process that typically starts with phosphorus oxychloride, which is reacted with sodium ethoxide and sodium 1-propanethiolate, followed by treatment with 4-bromo-2-chlorophenol. This yields the active compound used in agricultural formulations.

Carcinogenicity

In a 2 year carcinogenicity study mice were given diets containing 0, 1, 30, or 100 ppm profenofos (equivalent to 0, 0.15, 4.5, or 15 mg/kg/day) for 85 weeks (males) or 97 weeks (females) . No treatment related clinical signs were observed. No treatment-related gross or microscopic lesions, tumors, or biologically significant differences in body weight or food consumption were observed between controls and profenofos-treated animals. Plasma and erythrocyte cholinesterase inhibition occurred at dose levels of 4.5 and 15 mg/kg/day. In another carcinogenicity study, rats were fed diets containing 0, 0.3, 10, or 100 ppm profenofos (equivalent to 0, 0.015, 0.5, or 5 mg/kg/day) for 2 years, and there was no increase in tumor incidence in any treated group compared to the control group .

Environmental Fate

Plant. Dislodgable residues of profenofos on cotton leaf 0, 24, 48, 72 and 96 hours after application (1.1 kg/ha) were 3.5, 1.1, 0.74, 0.51 and 0.35 μg/m2, respectively (Buck et al., 1980)
Photolytic. When profenofos in an aqueous buffer solution (pH 7.0) was exposed to filtered UV light (λ >290 nm) for 24 hours at 25 and 50°C, 29 and 61% respectively decomposed to 4-bromo-2-chlorophenol and 4-bromo-2-chlorophenyl ethyl hydrogen ph
Chemical/Physical. Emits toxic fumes of bromine, chlorine phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

The metabolic transformations of profenofos in plants and animals are similar and occur via hydrolysis to 4-bromo-2-chlorophenol which is then conjugated.

Metabolism

Profenofos orally administered to rats is rapidly excreted, mainly in the urine. The principal degradation route is hydrolysis to 4-bromo-2-chlorophenol followed by conjugation. DT₅₀ in soil is about 1 week.

Toxicity evaluation

The acute oral LD₅₀ for rats is 358 mg/kg. Inhalation LC50 (4 h) for rats is about 3 mg/L air. NOEL (2 yr) for rats is 0.3 mg/kg diet (0.015 mg/kg/d). ADI is 0.01 mg/kg b.w.

Degradation

Profenofos is stable under neutral and slightly acid conditions but it is hydrolysed in alkaline solution. The DT₅₀ values at pH 5, 7 and 9 (20°C) were 93 days, 14.6 days and 5.7 hours, respectively (PM).

Profenofos Preparation Products And Raw materials

Raw materials

POTASSIUM HYDROGENSULFIDE, 2-Chlorophenol Solvent THIOPHOSPHORYL CHLORIDE 4-Bromo-2-chlorophenol

Chlorobenzene Bromine Diethyl chlorothiophosphate EMULSIFIER 1-Bromopropane

Phenylphosphonic acid SULPHOSUCCINIC ACID ESTER

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Preparation Products

Phosphorus-containing intermediates of asymmetric organophosphorus pesticides Prothiofos 1-Propanesulfonic acid

Profenofos Suppliers

Global( 267)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Qingdao Trust Agri Chemical Co.,Ltd	+86-008615963231493 +86-008613573296305	trustagri@hotmail.com	China	299	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Longyan Tianhua Biological Technology Co., Ltd	0086 18039857276 18039857276		CHINA	2783	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Qingdao Trust Agri Chemical Co.,Ltd	58
airuikechemical co., ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shandong chuangyingchemical Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hubei Ipure Biology Co., Ltd	58
Longyan Tianhua Biological Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Profenofos manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Profenofos 41198-08-7		100KG	98	200TONS	Qingdao Trust Agri Chemical Co.,Ltd
2024-12-24	Profenofos 41198-08-7		1Kg	99.99%	20 tons	airuikechemical co., ltd.
2020-11-16	Profenofos 41198-08-7	$8.00	1Kg/Bag	99%	20 Tons	Longyan Tianhua Biological Technology Co., Ltd

Profenofos
41198-08-7
$0.00
98
Qingdao Trust Agri Chemical Co.,Ltd

Profenofos
41198-08-7
99.99%
airuikechemical co., ltd.

Profenofos
41198-08-7
$8.00
99%
Longyan Tianhua Biological Technology Co., Ltd

Profenofos Spectrum

Profenofos(41198-08-7)MS Profenofos(41198-08-7)¹HNMR Profenofos(41198-08-7)IR1

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cga15324 Polycron E.C. Profenofos E.C. O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate profenofos (ISO) CGA 15324S 4-Bromo-2-chloro-1-(ethoxy-propylsulfanylphosphoryl)oxybenzene O-Ethyl S-propyl O-(2-chloro-4-bromophenyl)thiophosphate O-Ethyl-S-n-propyl-O-(2-chloro-4-bromophenyl)thiophosphate Profeniofos Thiophosphoric acid O-(4-bromo-2-chlorophenyl)O-ethyl S-propyl ester Profenofos Standard Profenofos 250mg [41198-08-7] Calofos Ictacron Prowess TaMbo o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate FERTIFENOPHOS FORNOFOS CURACRON CURACRON(R) Curacron(Ciba-Geigy) Polycron Nonacron phosphorothioicacid,o-(4-bromo-2-chlorophenyl)-o-ethyl-s-propylester SANOFOS Selecron SELECRON(R) ROMIFOS PRAHAR PROFENPHOS POLYCRON(R) POLYCRON O-(4-BROMO-2-CHLOROPHENYL)-O-ETHYL-S-PROPYL PHOSPHOROTHIOATE PROFENOFOS PESTANAL, 250 MG PROFENOFOS, 250MG, NEAT O-[4-Bromo-2-chloro-phenyl]-O-ethyl-S-n-propyl phosphorothioate S-n-Propyl-O-ethyl-O-2-chloro-4-bromo phenyl thiophosphate profenofos (bsi,iso,ansi,esa) (R,S)-PROFENOFOS Profenofos Profenofos 0.2 Profenofos Solution, 100ppm Profenofos Solution, 1000ppm Probromophos EC Probromophosphorus crude oil Profenofos Solution in Hexane Profenofos@100 μg/mL in MeOH ProfenofosSolution,100mg/L,1ml Profenofos@1000 μg/mL in Acetone ProfenofosSolution,1,000mg/L,1ml ProfenofosSolution,10mg/L,10ml Profenofos 50%EC organic insecticide 41198-08-7 Profenofos in Acetone C16330000 Profenofos L16330000CY Profenofos 10μg/mLin Cyclohexane Profenofos 10.0 μg/ml Cyclohexane Profenofos 100 μg/ml Acetonitrile Profenofos 100 μg/ml Toluene