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4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER structure

CAS No.: 29681-42-3

Chemical Name:: 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Synonyms: METHYL 4-BROMOPICOLINATE;METHYL 4-BROMOPYRIDINE-2-CARBOXYLATE;Picolinic acid, 4-bro;Methyl 4-broMopyridine-2-...;METHYL 4-BROMO-2-PYRIDINECARBOXYLATE;4-BROMO-PYRIDINE-2-CARBOXYLIC ACID MET;Picolinic acid, 4-bromo-, methyl ester;Methyl 4-bromopyridine-2-carboxylate 97%;Methyl 4-broMopyridine-2-carboxylate, 97+%;4-Bromo-2-pyridinecarboxylic acid methyl ester

CBNumber:: CB9200016

Molecular Formula:: C7H6BrNO2

Molecular Weight:: 216.03

MDL Number:: MFCD07374897

MOL File:: 29681-42-3.mol

MSDS File:: SDS

Last updated:2026-05-28 04:43:55

Product description	Number	Pack Size	Price
Methyl 4-bromopicolinate	FM74988	0.005kg	$150
Methyl 4-bromopicolinate	FM74988	0.01kg	$172.95
Methyl 4-bromopicolinate	FM74988	0.025kg	$355.5
Methyl 4-bromopicolinate	FM74988	0.05kg	$653.35
Methyl 4-bromopicolinate	FM74988	0.1kg	$1191.41
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4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Properties

Melting point	54-56
Boiling point	286.0±20.0 °C(Predicted)
Density	1.579±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
pka	-0.25±0.10(Predicted)
form	Solid
Appearance	Off-white to light yellow Solid
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C7H6BrNO2/c1-11-7(10)6-4-5(8)2-3-9-6/h2-4H,1H3
InChIKey	JZFLATQBIPILFS-UHFFFAOYSA-N
SMILES	C1(C(OC)=O)=NC=CC(Br)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

Safety Statements

Hazard Note

Irritant/Keep Cold

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	1
2		0

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FM74988	Methyl 4-bromopicolinate	29681-42-3	0.005kg	$150	2026-06-04	Buy
Biosynth	FM74988	Methyl 4-bromopicolinate	29681-42-3	0.01kg	$172.95	2026-06-04	Buy
Biosynth	FM74988	Methyl 4-bromopicolinate	29681-42-3	0.025kg	$355.5	2026-06-04	Buy
Biosynth	FM74988	Methyl 4-bromopicolinate	29681-42-3	0.05kg	$653.35	2026-06-04	Buy
Biosynth	FM74988	Methyl 4-bromopicolinate	29681-42-3	0.1kg	$1191.41	2026-06-04	Buy

Product number	Packaging	Price	Buy
FM74988	0.005kg	$150	Buy
FM74988	0.01kg	$172.95	Buy
FM74988	0.025kg	$355.5	Buy
FM74988	0.05kg	$653.35	Buy
FM74988	0.1kg	$1191.41	Buy

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Uses,Production

Chemical Properties

yellow solid

Uses

It finds its application as a useful synthetic intermediate and in the straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals. It is used in the synthesis of biaryl mannoside FimH inhibitors for use in urinary infection treatment.

Synthesis

600-22-6

19524-06-2

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

29681-42-3

Methyl 4-bromopyridine-2-carboxylate (147) was synthesized as follows: first, 4-bromopyridine hydrochloride (595 mg, 3.06 mmol) was dissolved in dichloromethane (DCM, 20 mL), washed with saturated aqueous sodium bicarbonate (NaHCO3) (2 × 20 mL), followed by drying and filtration with anhydrous magnesium sulfate (MgSO4). The filtrate was adjusted to 45 mL by the addition of additional DCM, followed by the addition of water (3 mL), iron(II) sulfate heptahydrate (8.51 g, 30.6 mmol) and concentrated sulfuric acid (H2SO4, 0.95 mL, 9.18 mmol). In another flask, methyl pyruvate (4.15 mL, 46 mmol) was treated with hydrogen peroxide (3.5 mL, 30.6 mmol, 30% aqueous solution) in a mixture at -10 °C, which was subsequently added to the above DCM/water mixture under vigorous stirring, keeping the temperature at -10 °C. After 15 min of reaction, the reaction mixture was diluted with ice water (100 mL) and extracted with DCM (4 x 20 mL). The DCM phases were combined and dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. Purification by column chromatography (gradient elution conditions: first using 10-40% ethyl acetate (EtOAc) in heptane solution containing 0.5% triethylamine, followed by 0-20% EtOAc/heptane containing 0.5% triethylamine) gave the target compound. Yield: 211 mg (32%). lC/MS retention time (tv) 0.98 min. mass spectra (ES+) m/z 218, 216 ([M+H]+).

References

[1] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 199-200
[2] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 288-289
[3] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 288-289

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Potassium permanganate Methanol Thionyl chloride 4-Bromo-2-methylpyridine 4-Bromopyridine-2-carboxylic acid

Methyl pyruvate 4-Bromopyridine hydrochloride (TRIMETHYLSILYL)DIAZOMETHANE Sodium bicarbonate Hydrogen peroxide

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Preparation Products

4-Bromo-2-pyridinemethanol 4-phenoxypyridine-2-carboxylic acid

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Suppliers

Global( 199)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	938	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Accela ChemBio Inc.	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Jinan Liheng Biotechnology Co., Ltd.	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29681-42-3	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2021-10-19	4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 29681-42-3	$10.00	1KG	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd
2020-05-13	Methyl 4-bromopyridine-2-carboxylate 29681-42-3		1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29681-42-3
$1.10
99.00%
Dideu Industries Group Limited

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
29681-42-3
$10.00
99%
Hebei Zhanyao Biotechnology Co. Ltd

Methyl 4-bromopyridine-2-carboxylate
29681-42-3
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Spectrum

4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(29681-42-3)¹HNMR

29681-42-3(4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER)Related Search:

4-Bromopyridine hydrochloride Methyl 6-bromonicotinate 4-Bromopyridine-2-carboxylic acid 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 6-amino-3-bromopicolinate

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 4-BROMO-6-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Dimethyl 2-bromo-2,6-pyridinedicarboxylate 4-Bromo-pyridine-2-carboxylic acid ethyl ester

2-AMINO-4-BROMO-6-CARBOXYPYRIDINE METHYL ESTER Diethyl 4-bromopyridine-2,6-dicarboxylate

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METHYL 4-BROMO-2-PYRIDINECARBOXYLATE 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 4-bromopyridine-2-carboxylate 97% 4-Bromo-2-pyridinecarboxylic acid methyl ester Methyl 4-broMopyridine-2-... Methyl 4-broMopyridine-2-carboxylate, 97+% Methyl 4-bromopicolinate, 4-Bromo-2-(methoxycarbonyl)pyridine Picolinic acid, 4-bromo-, methyl ester 2-Pyridinecarboxylic acid, 4-broMo-, Methyl ester Picolinic acid, 4-bro 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID MET 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH METHYL 4-BROMOPICOLINATE METHYL 4-BROMOPYRIDINE-2-CARBOXYLATE 29681-42-3 blocks Bromides Carboxes Pyridines