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2-Nitroacetophenone

2-Nitroacetophenone Structure
2-Nitroacetophenone structure
CAS No.
577-59-3
Chemical Name:
2-Nitroacetophenone
Synonyms
1-(2-nitrophenyl)ethanone;NSC 3641;AKOS 233-65;AURORA 14018;AKOS BBS-00003220;2-Nitroacetophene;2'-Nitroacetophne;2-NITROACETOPHENONE;O-NITROACETOPHENONE;2’-nitro-acetophenon
CBNumber:
CB9208092
Molecular Formula:
C8H7NO3
Molecular Weight:
165.15
MDL Number:
MFCD00007144
MOL File:
577-59-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:10
Product description Number Pack Size Price
2′-Nitroacetophenone 95% N9209 10g $31.1
2′-Nitroacetophenone 95% N9209 1g $22.8
2'-Nitroacetophenone >96.0%(GC) N0110 5g $21
2'-Nitroacetophenone >96.0%(GC) N0110 25g $50
2′-Nitroacetophenone 95% N9209 25g $73.8
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2-Nitroacetophenone Properties

Melting point 76-78 °C(lit.)
Boiling point 202 °C(lit.)
Density 1.23
refractive index n20/D 1.55(lit.)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
form Solid
color Brown
Water Solubility Insoluble
FreezingPoint 24.0 to 28.0 ℃
BRN 1102322
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChI 1S/C8H7NO3/c1-6(10)7-4-2-3-5-8(7)9(11)12/h2-5H,1H3
InChIKey SUGXZLKUDLDTKX-UHFFFAOYSA-N
SMILES CC(=O)c1ccccc1[N+]([O-])=O
CAS DataBase Reference 577-59-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 52L53K4X3O
NIST Chemistry Reference Ethanone, 1-(2-nitrophenyl)-(577-59-3)
EPA Substance Registry System 2-Nitroacetophenone (577-59-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25
WGK Germany  3
RTECS  AM9625000
Hazard Note  Harmful
TSCA  TSCA listed
HS Code  29147090
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
1 0

2-Nitroacetophenone price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N9209 2′-Nitroacetophenone 95% 577-59-3 10g $31.1 2026-04-30 Buy
Sigma-Aldrich N9209 2′-Nitroacetophenone 95% 577-59-3 1g $22.8 2022-05-15 Buy
TCI Chemical N0110 2'-Nitroacetophenone >96.0%(GC) 577-59-3 5g $21 2026-04-30 Buy
TCI Chemical N0110 2'-Nitroacetophenone >96.0%(GC) 577-59-3 25g $50 2026-04-30 Buy
Sigma-Aldrich N9209 2′-Nitroacetophenone 95% 577-59-3 25g $73.8 2026-04-30 Buy
Product number Packaging Price Buy
N9209 10g $31.1 Buy
N9209 1g $22.8 Buy
N0110 5g $21 Buy
N0110 25g $50 Buy
N9209 25g $73.8 Buy

2-Nitroacetophenone Chemical Properties,Uses,Production

Chemical Properties

yellow-green liquid or crystals. Soluble in alcohol, ether and chloroform, slightly soluble in water.

Uses

2'-Nitroacetophenone is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. It is also used as a synthetic reagent. It is the sensitizer which can be used as pharmaceutical intermediates.

Uses

2''-Nitroacetophenone (cas# 577-59-3) is a compound useful in organic synthesis. It is also used as an intermediate for photosensitive materials.

Preparation

o-Nitroacetophenone is synthesized from o-nitroethylbenzene by oxidation. Add o-nitroethylbenzene, decanoic acid and initiator azobisisobutyronitrile into the reaction tower, and at the same time slowly pass air into the tower, keep the pressure at 0.3-0.8MPa, and control the oxidation at 120-130°C to generate 2-Nitroacetophenone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 3631, 1978 DOI: 10.1021/jo00412a058
Journal of the American Chemical Society, 105, p. 943, 1983 DOI: 10.1021/ja00342a050
Synthesis, p. 228, 1988 DOI: 10.1055/s-1988-27522

General Description

Clear yellow liquid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Fire Hazard

2-Nitroacetophenone is combustible.

2-Nitroacetophenone synthesis

98-86-2
577-59-3
Synthesis of 2-Nitroacetophenone from Acetophenone

2-Nitroacetophenone Preparation Products And Raw materials

Raw materials

Decanoic acid AIBN 2-Ethylnitrobenzene 1-Iodo-2-nitrobenzene 1-ETHYNYL-2-NITRO-BENZENE
VINYLOXYTRIMETHYLSILANE

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Preparation Products

3-Nitroacetophenone 3-(diMethylaMino)-1-(3-nitrophenyl)prop-2-en-1-one Phosphoramidous acid. N.N-bis(1-methylethyl)-. 2-cyanoethyl [1-(2-nitrophenyl)ethyl] ester) Benzenemethanamine, α-methyl-2-nitro-, (αS)- 3-[4-(DIMETHYLAMINO)PHENYL]-1-(2-NITROPHENYL)PROP-2-EN-1-ONE
5-Chloro-3-methylbenzo[c]isoxazole

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2-Nitroacetophenone Suppliers

Global( 347)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Shaanxi Dideu Medichem Co. Ltd 		+8617392709771 1097@dideu.com China 3996 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58

View Lastest Price from 2-Nitroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Nitroacetophenone pictures 2026-03-20 2-Nitroacetophenone
577-59-3
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Nitroacetophenone pictures 2025-12-24 2-Nitroacetophenone
577-59-3
 US $555.00 / ASSAYS 1ASSAYS 98% 1T Shaanxi Dideu Medichem Co. Ltd
2-Nitroacetophenone pictures 2025-09-25 2-Nitroacetophenone
577-59-3
 US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

2-Nitroacetophenone Spectrum

2-Nitroacetophenone(577-59-3)MS2-Nitroacetophenone(577-59-3)1HNMR2-Nitroacetophenone(577-59-3)13CNMR2-Nitroacetophenone(577-59-3)IR12-Nitroacetophenone(577-59-3)IR22-Nitroacetophenone(577-59-3)Raman

577-59-3(2-Nitroacetophenone)Related Search:

Methyl acrylate 4'-Bromoacetophenone 2',4'-Dichloroacetophenone L-PICEIN 2'-Hydroxyacetophenone
Kresoxim-methyl 4'-Hydroxyacetophenone 4-Nitroacetophenone 2-Bromoacetophenone 2-Nitrophenylacetonitrile
Acetophenone Methylparaben 3-Nitroacetophenone Dichloroacetonitrile Bensulfuron methyl
3-Aminoacetophenone Thiophanate-methyl 2-Nitrophenylacetic acid

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Neighboring nitrobenzene ethyl ketone 2’-nitro-acetophenon AKOS BBS-00003220 1-(2-nitrophenyl)ethanone 2-NITROACETOPHENONE LABOTEST-BB LT01895210 AURORA 14018 ETHANONE, 1-(2-NITROPHENYL)- 1-(2-nitrophenyl)-ethanon 2-Nitroacetophenone,97% 1-(2-nitrophenyl)-Ethanone2-Nitroacetophenone 2-nitro-1-phenylethanone 2-Nitroacetophene 1-Acetyl-2-nitrobenzene o-Nitroacetophenone,95% 1-(2-Nitrophenyl)ethan-1-one, 2-Acetylnitrobenzene o-Nitroacetophenone, 95% 2.5GR Methyl-o-nitrophenylketone NSC 3641 o-nitroacetonphenone 2-p-nitroacetophenone 2'-Nitroacetophenone, 95+% 2-acetylnitrobenzene Acetophenone, 2'-nitro- Methyl 2-nitrophenyl ketone methyl2-nitrophenylketone o-Acetylnitrobenzene o-Nitro(acetyl)benzene o-nitrophenyl methyl ketone O-NITROACETOPHENONE AKOS 233-65 2'-Nitroacetophenone> 2'-Nitroacetophne 2'-Nitroacetophenone 2′-Nitroacetophenone, CAS 577-59-3 577-59-3 CH3COC6H4NO2 NO2C6H4COCH3 C8H7BNO3 KETONE Building Blocks C7 to C8 Carbonyl Compounds Ketones Organic Building Blocks Aromatic Acetophenones & Derivatives (substituted) Aromatics Miscellaneous Reagents C7 to C8 Carbonyl Compounds Ketones pharmaceutical intermediates Carbonyl Compounds