(S)-1,4-Benzodioxane-2-carboxylic acid
- CAS No.
- 70918-54-6
- Chemical Name:
- (S)-1,4-Benzodioxane-2-carboxylic acid
- Synonyms
- AfaL;anine [INN];Afalanine [INN];(S)-1,4-BENZODIOXAN 2-CARBOXYLIC ACID;(S)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID;(S)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-CARBOXYLIC ACID;(2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid;(3S)-2,3-Dihydro-1,4-benzodioxine-3-carboxylic acid;(S)-2,3-DIHYDRO-BENZO[1,4]DIOXINE-2-CARBOXYLIC ACID;(S)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
- CBNumber:
- CB9215993
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD00239408
- MOL File:
- 70918-54-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylicAcid | B198710 | 2.5g | $605 |
| (S)-1,4-Benzodioxane-2-carboxylic acid 95% | OR913812 | 1g | $435 |
| (S)-2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid | FD140110 | 1g | $450 |
| (S)-1,4-Benzodioxane-2-carboxylic acid | 0998AC | 1g | $270 |
| (S)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID 95.00% | CCH0001203 | 1G | $274.05 |
| More product size | |||
| Melting point | 96-99 °C |
|---|---|
| alpha | -83 º (c=1.5% in chloroform) |
| Boiling point | 347.2±41.0 °C(Predicted) |
| Density | 1.379±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 2.69±0.20(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | [α]20/D 83±2°, c = 1.5% in chloroform |
| BRN | 5742836 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 2932990090 |
(S)-1,4-Benzodioxane-2-carboxylic acid price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B198710 | (S)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylicAcid | 70918-54-6 | 2.5g | $605 | 2021-12-16 | Buy |
| Apolloscientific | OR913812 | (S)-1,4-Benzodioxane-2-carboxylic acid 95% | 70918-54-6 | 1g | $435 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD140110 | (S)-2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid | 70918-54-6 | 1g | $450 | 2021-12-16 | Buy |
| AK Scientific | 0998AC | (S)-1,4-Benzodioxane-2-carboxylic acid | 70918-54-6 | 1g | $270 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0001203 | (S)-1,4-BENZODIOXANE-2-CARBOXYLIC ACID 95.00% | 70918-54-6 | 1G | $274.05 | 2021-12-16 | Buy |
(S)-1,4-Benzodioxane-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
(S)-2,3-Dihydrobenzo[1,4]dioxine-2-carboxylic Acid is an intermediate used to prepare 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as α1-adrenoceptor antagonists and antihypertensive agents. It is also used to synthesize G protein-coupled receptor antagonists.
Synthesis
3663-82-9
3663-80-7
1. Weigh (2,3-dihydrobenzo[b][1,4]dioxohexen-2-yl)methanol (compound b) and dissolve in 0.3 N aqueous KOH (1.3 equiv). 2. KMnO4 (2.0 eq.) was slowly added at 0 °C. 3. The reaction mixture was stirred at low temperature for about 10 minutes, followed by stirring at room temperature overnight. 4. After completion of the reaction, the organic phase was extracted with dichloromethane. 5. The organic phase was washed with water and subsequently dried with anhydrous sodium sulfate and concentrated to give a white solid, the crude product of 4-benzodioxane-2-carboxylic acid (compound c). 6. The crude product was purified by rapid chromatography on silica gel in 92.5% yield.
References
[1] Patent: CN105985328, 2016, A. Location in patent: Paragraph 0063; 0071; 0072
(S)-1,4-Benzodioxane-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14343 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from (S)-1,4-Benzodioxane-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-10 | (S)-1,4-Benzodioxane-2-carboxylic acid
70918-54-6
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- (S)-1,4-Benzodioxane-2-carboxylic acid
70918-54-6
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
