2-Bromo-1-fluoro-4-(methoxymethyl) benzene
- CAS No.
- 887268-22-6
- Chemical Name:
- 2-Bromo-1-fluoro-4-(methoxymethyl) benzene
- Synonyms
- 2-BROMO-4-(METHOXYMETHYL)FLUOROBENZENE;2-Bromo-1-fluoro-4-(methoxymethyl) benzene;Benzene, 2-bromo-1-fluoro-4-(methoxymethyl)-
- CBNumber:
- CB9216925
- Molecular Formula:
- C8H8BrFO
- Molecular Weight:
- 219.05
- MDL Number:
- MFCD04116324
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2903998090 |
2-Bromo-1-fluoro-4-(methoxymethyl) benzene price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC2422 | 2-Bromo-4-(methoxymethyl)fluorobenzene 95% | 887268-22-6 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC2422 | 2-Bromo-4-(methoxymethyl)fluorobenzene 95% | 887268-22-6 | 250mg | $30 | 2026-06-04 | Buy |
| Apolloscientific | PC2422 | 2-Bromo-4-(methoxymethyl)fluorobenzene 95% | 887268-22-6 | 1g | $74 | 2026-06-04 | Buy |
| Apolloscientific | PC2422 | 2-Bromo-4-(methoxymethyl)fluorobenzene 95% | 887268-22-6 | 5g | $240 | 2026-06-04 | Buy |
| Apolloscientific | PC2422 | 2-Bromo-4-(methoxymethyl)fluorobenzene 95% | 887268-22-6 | 10g | $404 | 2026-06-04 | Buy |
2-Bromo-1-fluoro-4-(methoxymethyl) benzene Chemical Properties, Uses, Production
Synthesis
77771-03-0
74-88-4
887268-22-6
To a solution of 3-bromo-4-fluorobenzyl alcohol (5.00 g, 24.4 mmol) in anhydrous N,N-dimethylformamide (50 mL) was added a suspension of 60% sodium hydride in mineral oil (1.37 g, 34.2 mmol) in batches at 0 °C. The reaction mixture was stirred at 0 °C for 30 min. Subsequently, iodomethane (4.15 g, 29.3 mmol) was added at the same temperature. The mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (200 mL) and extracted with ethyl acetate (3 x 200 mL). The organic layers were combined, washed with brine (50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuum and the residue was purified by column chromatography using a petroleum ether solution of 2% to 5% ethyl acetate as eluent to afford the target product 2-bromo-1-fluoro-4-methoxymethylbenzene as a colorless oil (4.50 g, 84% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.57 (dd, J=6.4,2.0 Hz, 1H), 7.28-7.23 (m, 1H), 7.11 (t, J=8.0 Hz, 1H), 4.42 (s, 2H), 3.41 (s, 3H).
References
[1] Patent: US2018/162868, 2018, A1. Location in patent: Paragraph 1534-1535
[2] Patent: US2004/220194, 2004, A1. Location in patent: Page 23
[3] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 20
2-Bromo-1-fluoro-4-(methoxymethyl) benzene Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-1-fluoro-4-(methoxymethyl) benzene Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3827 | 58 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3537 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanjing YakeLun Pharmaceutical Co., Ltd. | 025-66096098 3165145969 | sales@accoronpharm.com | China | 3924 | 55 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2812 | 58 |
