3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 2881-63-2
- Chemical Name:
- 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Synonyms
- NSC 406743;ETHYL (4-CHLOROBENZOYL)ACETATE;Ethyl (4-chlorobenzoyl)acetate, >=97%;Ethyl 4-chloro-β-oxobenzenepropanoate;2-[(4-chlorophenyl)-oxomethyl]butanoate;Ethyl 3-Oxo-3-(4-chlorophenyl)propionate;ETHYL 3-(4-CHLOROPHENYL)-3-OXOPROPANOATE;Ethyl 3-(4-chlorophenyl)-3-oxo-propionate;Benzenepropanoicacid,4-chloro-β-oxo-,ethylester;3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl ester
- CBNumber:
- CB9217447
- Molecular Formula:
- C11H11ClO3
- Molecular Weight:
- 226.66
- MDL Number:
- MFCD00018713
- MOL File:
- 2881-63-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl (4-chlorobenzoyl)acetate | 559210 | 1g | $124 |
| Ethyl (4-chlorobenzoyl)acetate | 559210 | 5g | $225 |
| Ethyl 3-Oxo-3-(4-chlorophenyl)propionate >98.0%(GC) | E1059 | 1g | $39 |
| Ethyl 3-Oxo-3-(4-chlorophenyl)propionate >98.0%(GC) | E1059 | 5g | $136 |
| Ethyl 3-(4-chlorophenyl)-3-oxo-propionate >98% | E68007 | 1g | $40 |
| More product size | |||
| Melting point | 38 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 268-269 °C(lit.) |
| Density | 1.218 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Acetone |
| pka | 9.56±0.25(Predicted) |
| form | powder to lump |
| color | White to Orange to Green |
| InChI | InChI=1S/C11H11ClO3/c1-2-15-11(14)7-10(13)8-3-5-9(12)6-4-8/h3-6H,2,7H2,1H3 |
| InChIKey | DGCZHKABHPDNCC-UHFFFAOYSA-N |
| SMILES | C1(C=CC(Cl)=CC=1)C(=O)CC(=O)OCC |
| CAS DataBase Reference | 2881-63-2(CAS DataBase Reference) |
| FDA UNII | M6EC2D6ZXZ |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H319-H335-H332-H302-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| HS Code | 2918300090 |
| Storage Class | 11 - Combustible Solids |
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559210 | Ethyl (4-chlorobenzoyl)acetate | 2881-63-2 | 1g | $124 | 2026-04-30 | Buy |
| Sigma-Aldrich | 559210 | Ethyl (4-chlorobenzoyl)acetate | 2881-63-2 | 5g | $225 | 2026-04-30 | Buy |
| TCI Chemical | E1059 | Ethyl 3-Oxo-3-(4-chlorophenyl)propionate >98.0%(GC) | 2881-63-2 | 1g | $39 | 2026-04-30 | Buy |
| TCI Chemical | E1059 | Ethyl 3-Oxo-3-(4-chlorophenyl)propionate >98.0%(GC) | 2881-63-2 | 5g | $136 | 2026-04-30 | Buy |
| Synthonix | E68007 | Ethyl 3-(4-chlorophenyl)-3-oxo-propionate >98% | 2881-63-2 | 1g | $40 | 2026-05-06 | Buy |
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Uses
Ethyl (4-chlorobenzoyl)acetate may be used to synthesize 2-(carboethoxy)-3-(4′-chloro)phenylquinoxaline 1,4-dioxide.
Synthesis
3-(4-Chloro-phenyl)-3-oxo-propionic acid ethyl ester can be prepared from 4-chlorobenzoic acid.
To a solution of 4-chlorobenzoic acid (30.0 g, 0.192 mol) in DCM (250 mL) was added oxalyl chloride (25 mL, 0.288 mol) and then DMF (0.5 mL) was added dropwise. The reaction mixture was refluxed for 2 hours. The clarified yellow solution obtained was concentrated under vacuum to obtain the acyl chloride as a yellow liquid. TEA (67 mL) was added to a solution of potassium ethyl malonate (41 g, 0.241 mol) in acetonitrile (537 mL). After cooling in an ice-salt bath, MgCl2 (27.4 g, 0.288 mol) was added and the resulting mixture was stirred at this temperature for 3 hours. Acyl chloride (prepared as described above) was added and the reaction mixture was warmed to ambient temperature and stirred overnight. The mixture was cooled in an ice bath and 2N HCl (600 mL) was carefully added. The mixture was stirred in an ice bath for 1.5 hours and then transferred to a split funnel and extracted with ethyl acetate (3 x 200 mL). The combined organic layers were washed with saturated sodium bicarbonate (450 mL), brine (250 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford the crude product ethyl 3-(4-chlorophenyl)-3-oxo-propionate (48.6 g), which was used without purification.
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
View Lastest Price from 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-18 | ethyl 3-(4-chlorophenyl)-3-oxopropanoate
2881-63-2
|
US $0.00 / KG | 1KG | 99.2% | 100 tons | Honest Joy Holdings Limited | |
 |
2019-07-10 | 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
2881-63-2
|
US $1.00 / KG | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- ethyl 3-(4-chlorophenyl)-3-oxopropanoate
2881-63-2
- US $0.00 / KG
- 99.2%
- Honest Joy Holdings Limited
-
- 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
2881-63-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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