2-Bromonicotinic acid
- CAS No.
- 35905-85-2
- Chemical Name:
- 2-Bromonicotinic acid
- Synonyms
- AURORA 23320;2-Bromo Niacin;AKOS BBS-00001340;IFLAB-BB F1921-0015;2-BROMONICOTINIC ACID;2-BROMONICOTINIC ACID 98%;2-Bromonicotinic Acid >2-Bromonicotinic acid ,99%;2-Bromonicotinic acid, 96%;2-Bromo-3-pyridine carboxylic
- CBNumber:
- CB9218242
- Molecular Formula:
- C6H4BrNO2
- Molecular Weight:
- 202.01
- MDL Number:
- MFCD01646068
- MOL File:
- 35905-85-2.mol
- MSDS File:
- SDS
| Melting point | 200-203 °C(lit.) |
|---|---|
| Boiling point | 339.3±27.0 °C(Predicted) |
| Density | 1.813±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 2.12±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| CAS DataBase Reference | 35905-85-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29173990 | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (300g or 300ml) | |||||||||
| NFPA 704 |
|
2-Bromonicotinic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 632465 | 2-Bromopyridine-3-carboxylic acid 97% | 35905-85-2 | 5g | $22.75 | 2025-07-31 | Buy |
| Sigma-Aldrich | 632465 | 2-Bromopyridine-3-carboxylic acid 97% | 35905-85-2 | 1g | $27 | 2023-06-20 | Buy |
| TCI Chemical | B2626 | 2-Bromonicotinic Acid >98.0%(GC) | 35905-85-2 | 1g | $24 | 2025-07-31 | Buy |
| TCI Chemical | B2626 | 2-Bromonicotinic Acid >98.0%(GC) | 35905-85-2 | 5g | $88 | 2025-07-31 | Buy |
| TRC | B686043 | 2-Bromonicotinic Acid | 35905-85-2 | 5g | $75 | 2021-12-16 | Buy |
2-Bromonicotinic acid Chemical Properties,Uses,Production
Chemical Properties
Light yellow Cryst
Synthesis
3430-17-9
35905-85-2
General procedure for the synthesis of 2-bromonicotinic acid from 2-bromo-3-methylpyridine: 2-bromo-3-methylpyridine (25.0 mL, 213 mmol) was slowly added to a solution of potassium permanganate (87.7 g, 555 mmol) dissolved in 800 mL of water, and the mixture was stirred continuously for 5 hours under reflux conditions. Upon completion of the reaction, 600 mL of water was removed by distillation and the remaining suspension was separated by thermal filtration. The filtrate was washed with two portions of 50 mL of hot water, and the combined filtrates were acidified with concentrated hydrochloric acid to pH < 2. The precipitate was collected by filtration and dried in a vacuum drying oven to give 26.8 g of 2-bromonicotinic acid in 62% yield. Diphenylphosphoryl chloride was added dropwise to a solution of 2-bromonicotinic acid (15.0 g, 74.0 mmol) and triethylamine (11.4 mL, 81.4 mmol) dissolved in 140 mL of anhydrous tert-butanol. The reaction mixture was stirred under reflux conditions for 2 h. It was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in 150 mL of ethyl acetate and washed sequentially with three parts of 50 mL of water, three parts of 50 mL of saturated aqueous sodium bicarbonate solution and two parts of 50 mL of saturated saline. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. After static crystallization 15.3 g of the target product was obtained in 76% yield.
References
[1] Organic Letters, 2007, vol. 9, # 5, p. 891 - 894
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 165
[4] Tetrahedron, 2015, vol. 71, # 2, p. 252 - 258
[5] Journal of Organic Chemistry, 1949, vol. 14, p. 509,513
2-Bromonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20185 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13090 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 2-Bromonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 2-Bromonicotinic acid
35905-85-2
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 2-Bromonicotinic acid
35905-85-2
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-10-23 | 2-Bromonicotinic acid
35905-85-2
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 2-Bromonicotinic acid
35905-85-2
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-Bromonicotinic acid
35905-85-2
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Bromonicotinic acid
35905-85-2
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
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