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2-Methoxyethyl chloride

2-Methoxyethyl chloride Structure
2-Methoxyethyl chloride structure
CAS No.
627-42-9
Chemical Name:
2-Methoxyethyl chloride
Synonyms
1-CHLORO-2-METHOXYETHANE;2-CHLOROETHYL METHYL ETHER;Ethane, 1-chloro-2-methoxy-;2-chloroMethyl ethyl ether;JACS-627-42-9;2-Methoxyethyl chlor;2-Methoxyethylchlorid;Chloro-2-methoxyethane;2-Chlorethylmethylether;2-METHOXYETHYL CHLORIDE
CBNumber:
CB9219188
Molecular Formula:
C3H7ClO
Molecular Weight:
94.54
MDL Number:
MFCD00000972
MOL File:
627-42-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:19:00
Product description Number Pack Size Price
2-Chloroethyl methyl ether 98% 242349 5g $51.5
2-Chloroethyl methyl ether 98% 242349 100g $171
2-Chloroethyl Methyl Ether >98.0%(GC) C1173 25mL $35
2-Chloroethyl Methyl Ether >98.0%(GC) C1173 100mL $85
2-Chloroethyl Methyl Ether TRC-C367460-25G 25g $123
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2-Methoxyethyl chloride Properties

Melting point -55 °C
Boiling point 89-90 °C (lit.)
Density 1.035 g/mL at 25 °C (lit.)
refractive index n20/D 1.408(lit.)
Flash point 59 °F
storage temp. Inert atmosphere,Room Temperature
solubility 80g/l
form Liquid
color Clear colorless to yellow
Water Solubility 60 g/L (20 C)
BRN 1731028
Stability Volatile
InChI 1S/C3H7ClO/c1-5-3-2-4/h2-3H2,1H3
InChIKey XTIGGAHUZJWQMD-UHFFFAOYSA-N
SMILES COCCCl
CAS DataBase Reference 627-42-9(CAS DataBase Reference)
FDA UNII U890TJ10YM
NIST Chemistry Reference 2-Chloroethyl methyl ether(627-42-9)
EPA Substance Registry System Ethane, 1-chloro-2-methoxy- (627-42-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302-H315
Precautionary statements  P210-P301+P312+P330-P302+P352
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xn
Risk Statements  11-20/21/22-22
Safety Statements  36/37-23-16
RIDADR  UN 3271 3/PG 2
WGK Germany  3
F  9
TSCA  TSCA listed
HazardClass  3
PackingGroup  II
HS Code  29091900
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Oral
Flam. Liq. 2
Skin Irrit. 2
Hazardous Substances Data 627-42-9(Hazardous Substances Data)
NFPA 704
3
1 0

2-Methoxyethyl chloride price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 242349 2-Chloroethyl methyl ether 98% 627-42-9 5g $51.5 2026-04-30 Buy
Sigma-Aldrich 242349 2-Chloroethyl methyl ether 98% 627-42-9 100g $171 2026-04-30 Buy
TCI Chemical C1173 2-Chloroethyl Methyl Ether >98.0%(GC) 627-42-9 25mL $35 2026-04-30 Buy
TCI Chemical C1173 2-Chloroethyl Methyl Ether >98.0%(GC) 627-42-9 100mL $85 2026-04-30 Buy
TRC TRC-C367460-25G 2-Chloroethyl Methyl Ether 627-42-9 25g $123 2026-06-03 Buy
Product number Packaging Price Buy
242349 5g $51.5 Buy
242349 100g $171 Buy
C1173 25mL $35 Buy
C1173 100mL $85 Buy
TRC-C367460-25G 25g $123 Buy

2-Methoxyethyl chloride Chemical Properties,Uses,Production

Uses

2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.

Chemical Properties

clear colorless to yellowish liquid

Uses

2-Chloroethyl methyl ether was used in the synthesis of acyclic nucleosides of thieno[2,3-d] pyrimidine derivatives.

Uses

2-Chloroethyl methyl ether (2-Methoxyethyl chloride) was used in the synthesis of acyclic nucleosides of thieno[2,3-d]pyrimidine derivatives.

Synthesis

Dimethyl sulfate

77-78-1

2-Chloroethanol

107-07-3

2-Methoxyethyl chloride

627-42-9

To a round-bottomed flask equipped with a distillation apparatus, calcium carbonate (27.3 g, 273.2 mmol), dimethyl sulfate (23.5 mL, 248.4 mmol) and 2-chloroethanol (16.6 mL, 248.4 mmol) were added sequentially. The reaction mixture was heated to 120-130°C and the reaction was continued until distillation ceased (about overnight). After completion of the reaction, the distillate was diluted with ether and washed with 2N NaOH solution. The aqueous layer was again extracted with ether, and all ether layers were combined and dried with anhydrous magnesium sulfate (MgSO). Finally, the target product 2-chloroethyl methyl ether (16) was obtained as a colorless liquid by conventional distillation (collection of fractions with a vapor temperature of 88-90°C). Yield: 10.2 g, 43% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1784 - 1788
[2] Journal of the American Chemical Society, 1924, vol. 46, p. 2530

2-Methoxyethyl chloride Preparation Products And Raw materials

Raw materials

Methanol, chloro- DICHLORAMINE B 2,2'-Dichlorodiethyl ether Dimethyl sulfate Trimethyloxonium Tetrafluoroborate
2-Chloroethanol 1,4-Dichlorobutane

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Preparation Products

1-(2-Methoxyethyl)piperazine BIS(2-METHOXYETHYL)AMINE Chloromethane 1,4-Dioxane 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
4-(2-METHOXYETHOXY)ANILINE Tris(2-(2-methoxyethoxy)ethyl)amine 4-(2-methoxyethoxy)benzonitrile 1,4-Di-t-butyl-2,5-bis(2-methoxyethoxy)benzene, 99+% Redox shuttle ANL-RS2 1-(2-methoxyethyl)-1H-imidazole
Benzene, 1-chloro-2-(2-methoxyethoxy)-4-nitro- 1-(2-METHOXYETHYL)BENZIMIDAZOLE

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2-Methoxyethyl chloride Suppliers

Global( 362)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16512 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10236 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Jinan Finer Chemical Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Hubei Ipure Biology Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 2-Methoxyethyl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Chloro-2-methoxyethane pictures 2026-04-17 1-Chloro-2-methoxyethane
627-42-9
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1-Chloro-2-methoxyethane pictures 2025-12-01 1-Chloro-2-methoxyethane
627-42-9
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1-Chloro-2-methoxyethane pictures 2019-07-06 1-Chloro-2-methoxyethane
627-42-9
 $1.00 1KG 98% 100KG Career Henan Chemical Co

2-Methoxyethyl chloride Spectrum

2-Methoxyethyl chloride(627-42-9)MS2-Methoxyethyl chloride(627-42-9)1HNMR2-Methoxyethyl chloride(627-42-9)IR12-Methoxyethyl chloride(627-42-9)Raman

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1-chloro-2-methoxy-ethan 2-METHOXYETHYL CHLORIDE FOR SYNTHESIS 2-Chloroethyl methyl ether 98% 2-Chlorethylmethylether beta-chloroethylmethylether Ethane, 1-chloro-2-methoxy- ethane,1-chloro-2-methoxy ether,2-chloroethylmethyl Chloro-2-methoxyethane CHLOROETHYL METHYL ETHER 2-METHOXYETHYL CHLORIDE 2-Methoxyethyl chlor 2-Methoxyethylchlorid Ethyleneglycol monomethyl ether chloride 1-Methoxy-2-chloroethane 2-Chloroethyl methyl ether,98% JACS-627-42-9 2-Chloroethyl Methyl Ether > 2-ChloroethylmethyletheChemicalbookr98% 1-CHLORO-2-METHOXYETHANE 2-chloroMethyl ethyl ether 2-CHLOROETHYL METHYL ETHER 627-42-9 3188-30-2 CH3OCH2CH2Cl ClC2H4OCH3 C3H7OCl ClCH2CH2OCH3 Building Blocks Oxygen Compounds Organic Building Blocks Ethers HALOGEN