Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate
![Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate Structure](CAS/GIF/117337-19-6.gif)
- CAS No.
- 117337-19-6
- Chemical Name:
- Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate
- Synonyms
- FLUTHIACET-METHYL;kih-9201;Hsdb 7270;Eluthiacet-methyl;Semaglutide Impurity 9;Fluthiacet-methyl [iso];Fluthiacet-methyl Standard;Fluthiacet-methyl Solution;1000 μg/mL in Acetonitrile;C13862000 Fluthiacet-methyl
- CBNumber:
- CB9232165
- Molecular Formula:
- C15H15ClFN3O3S2
- Molecular Weight:
- 403.88
- MDL Number:
- MFCD03792701
- MOL File:
- 117337-19-6.mol
| Product description | Number | Pack Size | Price |
| Fluthiacet-methyl PESTANAL | 32464 | 25mg | $80.9 |
| Fluthiacet-methyl ≥98%(GC) | 450252 | 25mg | $340 |
| Fluthiacet-methyl 97% | MT-51867 | 0.5g | $590 |
| Fluthiacet-methyl 97% | MT-51867 | 0.5g | $590 |
| Fluthiacet-methyl | F599440 | 5mg | $330 |
| More product size | |||
Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate Properties
| Melting point | 104.6° |
|---|---|
| Boiling point | 503.5±60.0 °C(Predicted) |
| Density | 1.57±0.1 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| pka | -2.86±0.20(Predicted) |
| BRN | 11510131 |
| Henry's Law Constant | 4.8×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| FDA UNII | 7C989JK2XB |
| Pesticides Freedom of Information Act (FOIA) | Fluthiacet-methyl |
| EPA Substance Registry System | Fluthiacet-methyl (117337-19-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H400 |
| Precautionary statements | P273-P305+P351+P338 |
| Hazard Codes | Xi,N |
| Risk Statements | 36-50 |
| Safety Statements | 26-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HS Code | 29309090 |
| Hazardous Substances Data | 117337-19-6(Hazardous Substances Data) |
| Toxicity | LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Miyazawa) |
Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 32464 | Fluthiacet-methyl PESTANAL | 117337-19-6 | 25mg | $80.9 | 2022-05-15 | Buy |
| Usbiological | 450252 | Fluthiacet-methyl ≥98%(GC) | 117337-19-6 | 25mg | $340 | 2026-06-03 | Buy |
| AHH | MT-51867 | Fluthiacet-methyl 97% | 0.5g | $590 | 2026-05-26 | Buy | |
| AHH | MT-51867 | Fluthiacet-methyl 97% | 0.5g | $590 | 2026-05-25 | Buy | |
| TRC | F599440 | Fluthiacet-methyl | 117337-19-6 | 5mg | $330 | 2021-12-16 | Buy |
Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate Chemical Properties,Uses,Production
Chemical Properties
Pure product is white powdery solid, purity of industrial product ≥98%. Melting point 105.0~106.5°C, boiling point 249°C (decomposition). Relative density 0.43(20℃). Vapor pressure 4.41×10-4mPa(25℃). Partition coefficient KowlgP=3.77(25℃), Henry's constant 2.1×10-4Pa.m3/mol.Solubility in water(25℃ , mg/L):0.85(distilled water), 0.78(pH 5 and 7), 0.22(pH 9). Solubility in other solvents (25℃,g/L): methanol 4.41, acetone 101, toluene 84, acetonitrile 68.7, ethyl acetate 73.5, dichloromethane 531.0, n-octanol 1.86, n-hexane 0.232. DT50 in water (25℃): 484.8d(pH 5),17.7d( pH 7),0.2d (pH 9), photolysis in water DT50(25℃ ,44.7W/m2 ,300~400nm):5.88h(natural water),4.95d(distilled water)(25℃,44.7W/m2 ,300~400nm).
Uses
Herbicide.
Definition
ChEBI: Fluthiacet-methyl is a methyl ester resulting from the formal condensation of the carboxy group of fluthiacet with methanol. A proherbicide for fluthiacet, it is used for the control of broad-leaved weeds in crops such as maize and soya. It has a role as an agrochemical, an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and a proherbicide. It is an organic sulfide, a methyl ester, a member of monochlorobenzenes, a member of monofluorobenzenes and a thiadiazolopyridazine. It is functionally related to a fluthiacet.
Metabolic pathway
Fluthiacet methyl is converted to its isomer, urazole, by
glutathione S-transferase (GST) and glutathione (GSH)
from some plants and rat liver microsomes. Fluthiacet
methyl inhibits Protox (protoporphyrinogen oxidase)
activity after conversion to the corresponding urazole by
GST and GSH. Fluthiacet methyl is chemically
converted to urazole with a thiol anion in media by the
nucleophilic reaction. It is also suggested that a free
acid of urazole, desulfated urazole, and the oxidative
ring-cleaved formyl degradation products result from
hydrolysis with esterase from soybean seedlings.
When fluthiacet methyl is administered orally to
rats in a single dose, 63-85% of the dose is excreted
in the feces and 10-23% in the urine, respectively,
after 48 h. The main metabolite is the isomer of
fluthiacet methyl (urazole) which is also identified in
the soil degradation products. Monohydroxylated
products on the pyridazine ring are identified as
metabolites by rats only.
Methyl 2-[2-chloro-4-fluoro-5-[(3-oxo-5,6,7,8-tetrahydro-[1,3,4]thiadiazolo[3,4-a]pyridazin-1-ylidene)amino]phenyl]sulfanylacetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD. | 86-029-85456576 | daisy_wang@vip.163.com | China | 292 | 55 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4511 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20794 | 60 |
