3,4-BIS(BENZYLOXY)BENZOIC ACID
- CAS No.
- 1570-05-4
- Chemical Name:
- 3,4-BIS(BENZYLOXY)BENZOIC ACID
- Synonyms
- RARECHEM AL BE 0665;3,4-BIS(BENZYLOXY)BENZOIC ACID;3,4-Bis(phenylMethoxy)-benzoic Acid;Benzoic acid,3,4-bis(phenylmethoxy)-
- CBNumber:
- CB9234790
- Molecular Formula:
- C21H18O4
- Molecular Weight:
- 334.37
- MDL Number:
- MFCD01861843
- MOL File:
- 1570-05-4.mol
- MSDS File:
- SDS
| Melting point | 182 °C |
|---|---|
| Boiling point | 512.7±40.0 °C(Predicted) |
| Density | 1.232±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly, Heated), DMSO (Slightly) |
| form | Solid |
| pka | 4.31±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C21H18O4/c22-21(23)18-11-12-19(24-14-16-7-3-1-4-8-16)20(13-18)25-15-17-9-5-2-6-10-17/h1-13H,14-15H2,(H,22,23) |
| InChIKey | BYOKJLCIKSFPDU-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(OCC2=CC=CC=C2)C(OCC2=CC=CC=C2)=C1 |
3,4-BIS(BENZYLOXY)BENZOIC ACID price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B521350 | 3,4-Bis(phenylmethoxy)-benzoicAcid | 1570-05-4 | 25g | $1190 | 2021-12-16 | Buy |
| AK Scientific | D411 | 3,4-Bis(benzyloxy)benzoicacid | 1570-05-4 | 10g | $528 | 2021-12-16 | Buy |
| Crysdot | CD12137649 | 3,4-Bis(benzyloxy)benzoicacid 97% | 1570-05-4 | 25g | $594 | 2021-12-16 | Buy |
| AHH | MT-36858 | 3,4-Bis(benzyloxy)benzoicacid 97% | 1570-05-4 | 10g | $670 | 2021-12-16 | Buy |
| Acrotein | AC-3438 | 3,4-Bis(benzyloxy)benzoicacid 97% | 1570-05-4 | 25g | $913 | 2021-12-16 | Buy |
3,4-BIS(BENZYLOXY)BENZOIC ACID Chemical Properties,Uses,Production
Uses
3,4-Bis(phenylmethoxy)-benzoic Acid is a useful synthetic intermediate. It is an intermediate used to synthesize Jaboticabin (J210370) which is minor bioactive depside potent to treat chronic obstructive pulmonary disease.
Synthesis
54544-05-7
1570-05-4
C) Synthesis of 3,4-dibenzyloxybenzoic acid: Sodium hydroxide (1.2 g) was dissolved in methanol (100 mL) to prepare a methanolic solution of sodium hydroxide. This solution was added to a solution of methanol (50 mL) containing methyl 3,4-dibenzyloxybenzoate (4.64 g), and the reaction mixture was heated under reflux for 4 hours. After completion of the reaction, the methanol was evaporated under reduced pressure. The residue was dissolved in water (100 mL) and the aqueous layer was washed with ethyl acetate (2 x 50 mL). Subsequently, the aqueous layer was acidified to pH 2 with 2N hydrochloric acid, whereupon 3,4-dibenzyloxybenzoic acid precipitated as a precipitate. The precipitate was collected by filtration and dried under vacuum to give 2.4 g of 3,4-dibenzyloxybenzoic acid in 74% yield. The product was characterized by 1H NMR (CDCl3): δ 7.7 (2H, br s), 7.27-7.5 (10H, m), 6.98 (1H, d, J=8 Hz), 5.26 (2H, s), 5.22 (2H, s).
References
[1] Canadian Journal of Chemistry, 2006, vol. 84, # 10, p. 1411 - 1415
[2] Patent: WO2005/113489, 2005, A1. Location in patent: Page/Page column 90
[3] European Journal of Medicinal Chemistry, 1997, vol. 32, # 5, p. 409 - 423
[4] Heterocycles, 2014, vol. 8, # 2, p. 1371 - 1396
[5] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 24 - 33
3,4-BIS(BENZYLOXY)BENZOIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
3,4-BIS(BENZYLOXY)BENZOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29801 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6547 | 58 |
| Hangzhou Changjiu Pharmaceutical Technology Co. , Ltd. | 18918890396; 18918890396 | 49087067@qq.com | China | 52 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 4056 | 55 |
View Lastest Price from 3,4-BIS(BENZYLOXY)BENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-27 | 3,4-BIS(BENZYLOXY)BENZOIC ACID
1570-05-4
|
US $6.60 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 3,4-BIS(BENZYLOXY)BENZOIC ACID
1570-05-4
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co
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