Nitrilotriacetic acid
- CAS No.
- 139-13-9
- Chemical Name:
- Nitrilotriacetic acid
- Synonyms
- NTA;TRIGLYCINE;NITRILOTRIACETATE;NTA acid;TRILON A;Nitrilotriacetic;NITRILOACETIC ACID;2,2',2''-Nitrilotriacetic acid;nci-c02766;NITRILOACETATE
- CBNumber:
- CB9241989
- Molecular Formula:
- C6H9NO6
- Molecular Weight:
- 191.14
- MDL Number:
- MFCD00004287
- MOL File:
- 139-13-9.mol
| Product description | Number | Pack Size | Price |
| Nitrilotriacetic acid BioUltra, ≥99.0% (T) | 72559 | 100g | $90.8 |
| Nitrilotriacetic acid United States Pharmacopeia (USP) Reference Standard | 1463950 | 50mg | $376 |
| Nitrilotriacetic Acid >98.0%(T) | N0098 | 25g | $22 |
| Nitrilotriacetic Acid >98.0%(T) | N0098 | 500g | $65 |
| Nitrilotriacetic acid Sigma Grade, ≥99% | N9877 | 5g | $50.3 |
| More product size | |||
| Melting point | 245 °C (dec.)(lit.) |
|---|---|
| Boiling point | 326.86°C (rough estimate) |
| Density | 1.5784 (rough estimate) |
| vapor pressure | 0-0Pa at 20-25℃ |
| refractive index | 1.4860 (estimate) |
| Flash point | 100 °C |
| storage temp. | 2-8°C |
| solubility | 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless |
| form | Powder |
| pka | 3.03, 3.07, 10.70(at 20℃) |
| color | White |
| PH | 1.7-2.7 (23°C, 10g/L) |
| Water Solubility | Insoluble. <0.01 g/100 mL at 23 ºC |
| λmax |
λ: 260 nm Amax: 1.5 λ: 280 nm Amax: 0.05 |
| Merck | 14,6579 |
| BRN | 1710776 |
| LogP | -3.81 at 25℃ |
| Toxicology and Carcinogenesis | Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CASRN 139-13-9) (NTA) (CASRN 18662-53-8) (Na3-NTA-H2O) |
| CAS DataBase Reference | 139-13-9(CAS DataBase Reference) |
| FDA UNII | KA90006V9D |
| IARC | 2B (Vol. 48, 73) 1999 |
| NIST Chemistry Reference | Nitrilotriacetic acid(139-13-9) |
| Proposition 65 List | Nitrilotriacetic Acid |
| EPA Substance Registry System | Nitrilotriacetic acid (139-13-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.31 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H351 | |||||||||
| Precautionary statements | P201-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36-40-36/37/38-45-20/21/22 | |||||||||
| Safety Statements | 26-36/37-45-36/37/39-53 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AJ0175000 | |||||||||
| F | 21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29224995 | |||||||||
| Hazardous Substances Data | 139-13-9(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 1100 mg/kg | |||||||||
| NFPA 704 |
|
Nitrilotriacetic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 72559 | Nitrilotriacetic acid BioUltra, ≥99.0% (T) | 139-13-9 | 100g | $90.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1463950 | Nitrilotriacetic acid United States Pharmacopeia (USP) Reference Standard | 139-13-9 | 50mg | $376 | 2025-07-31 | Buy |
| TCI Chemical | N0098 | Nitrilotriacetic Acid >98.0%(T) | 139-13-9 | 25g | $22 | 2025-07-31 | Buy |
| TCI Chemical | N0098 | Nitrilotriacetic Acid >98.0%(T) | 139-13-9 | 500g | $65 | 2025-07-31 | Buy |
| Sigma-Aldrich | N9877 | Nitrilotriacetic acid Sigma Grade, ≥99% | 139-13-9 | 5g | $50.3 | 2025-07-31 | Buy |
Nitrilotriacetic acid Chemical Properties,Uses,Production
Chemical Properties
Nitrilotriacetic acid, also known as NTA, is a white crystalline powder. It can dissolve in ammonia and alkali solutions while being slightly soluble in hot water. However, it is insoluble in water and most organic solvents. NTA can form mono-, di-, and tribasic salts, all of which are soluble in water. Combustible. 70% biodegradable.
Uses
Used in sequestration of metals; chelometric analysis.
Uses
Nitrilotriacetic acid is a chelating agent which forms coordination compounds with metal ions. Nitrilotriacetic acid is used in complexometric titrations and as well as for protein isolation and purification in the His-tag method. This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: Nitrilotriacetic acid is a tricarboxylic acid and a NTA. It has a role as a nephrotoxic agent and a carcinogenic agent. It is a conjugate acid of a nitrilotriacetate(1-).
Preparation
The synthesis of nitrilotriacetic acid involves the following steps:
Chloroacetic acid is reacted with sodium hydroxide to produce sodium chloroacetate.
Sodium chloroacetate then reacts with ammonium chloride to form sodium aminotriacetate.
The resulting sodium aminotriacetate is acidified to obtain nitrilotriacetic acid.
Synthesis Reference(s)
The Journal of Organic Chemistry, 15, p. 46, 1950 DOI: 10.1021/jo01147a008
Air & Water Reactions
Water Insoluble.
Reactivity Profile
Nitrilotriacetic acid is incompatible with strong oxidizers, aluminum, copper, copper alloy and nickel. Nitrilotriacetic acid is also incompatible with strong bases.
Hazard
Possible carcinogen.
Health Hazard
Toxicity and health hazard of Nitrilotriacetic acid is low. Contact with eyes causes irritation.
Fire Hazard
Flash point data for Nitrilotriacetic acid are not available; however, Nitrilotriacetic acid is probably combustible.
Flammability and Explosibility
Non flammable
reaction suitability
reagent type: reductant
Biological Activity
Nitrilotriacetic (NTA) has the ability to link with histidine side chain of proteins. It can be used in fluorescent labelling, hexahistidine (His6)-tagged proteins for purification and surface immobilization.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx,.
Potential Exposure
Nitrilotriacetic acid (NTA) was used as a phosphate replacement in laundry detergents in the late 1960s. In 1971, the use of NTA was discontinued. The possibility of resumed use arose in 1980. NTA is now used in laundry detergents in states where phosphates are banned. NTA is also used as a boiler feed-water additive at a maximum use level of 5 ppm of trisodium salt. Currently, the remaining nondetergent uses of NTA are for water treatment, textile treatment; metal plating and cleaning; and pulp and paper processing.
Carcinogenicity
Nitrilotriacetic acid is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Nitrilotriacetic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8767 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5249 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Shandong Juchuang Chemical Co., LTD | +16837774622 | admin@juchuangchem.com | China | 295 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13595 | 58 |
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- Nov 13，2024
View Lastest Price from Nitrilotriacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-17 | Nitrilotriacetic acid
139-13-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-12-16 | Nitrilotriacetic acid
139-13-9
|
US $0.00 / mg | 98.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-11 | Nitrilotriacetic acid
139-13-9
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Nitrilotriacetic acid
139-13-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Nitrilotriacetic acid
139-13-9
- US $0.00 / mg
- 98.84%
- TargetMol Chemicals Inc.
-
- Nitrilotriacetic acid
139-13-9
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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