4-BROMO-2,5-DIFLUOROANILINE
- CAS No.
- 112279-60-4
- Chemical Name:
- 4-BROMO-2,5-DIFLUOROANILINE
- Synonyms
- 4-broMo-2,5-difluorobenzenaMine;4-BROMO-2,5-DIFLUOROANILINE;2,5-Difluoro-4-bromoaniline;4-Bromo-2,5-difluoroaniline98%;4-Bromo-2,5-difluoroaniline >4-Bromo-2,5-difluoroaniline 98%;4-Bromo-2,5-difluoro-phenylamine;Benzenamine, 4-bromo-2,5-difluoro-;4-BROMO-2,5-DIFLUOROANILINE ISO 9001：2015 REACH;4-bromo-2,5-difluorophenylamine,4-BroMo-2,5-difluoroaniline,4-Amino-2,5-difluorobromobenzene,4-Bromo-2,5-difluorobenzenamine
- CBNumber:
- CB9242885
- Molecular Formula:
- C6H4BrF2N
- Molecular Weight:
- 208
- MDL Number:
- MFCD01861125
- MOL File:
- 112279-60-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-2,5-difluoroaniline 97% | 638412 | 5g | $68.5 |
| 4-Bromo-2,5-difluoroaniline 97% | 638412 | 1g | $35 |
| 4-Bromo-2,5-difluoroaniline >98.0%(GC) | B2072 | 1g | $21 |
| 4-Bromo-2,5-difluoroaniline >98.0%(GC) | B2072 | 5g | $59 |
| 4-Bromo-2,5-difluoroaniline ≥98%(GC) | 45975 | 1G | $24.9 |
| More product size | |||
| Melting point | 74-78 °C (lit.) |
|---|---|
| Boiling point | 212.1±35.0 °C(Predicted) |
| Density | 1.788±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 1.48±0.10(Predicted) |
| color | White to Light yellow |
| BRN | 4741102 |
| InChI | InChI=1S/C6H4BrF2N/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,10H2 |
| InChIKey | XOYHFIQPPOJMFK-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(F)=C(Br)C=C1F |
| CAS DataBase Reference | 112279-60-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 28-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29214200 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-BROMO-2,5-DIFLUOROANILINE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 638412 | 4-Bromo-2,5-difluoroaniline 97% | 112279-60-4 | 5g | $68.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 638412 | 4-Bromo-2,5-difluoroaniline 97% | 112279-60-4 | 1g | $35 | 2023-06-20 | Buy |
| TCI Chemical | B2072 | 4-Bromo-2,5-difluoroaniline >98.0%(GC) | 112279-60-4 | 1g | $21 | 2026-04-30 | Buy |
| TCI Chemical | B2072 | 4-Bromo-2,5-difluoroaniline >98.0%(GC) | 112279-60-4 | 5g | $59 | 2026-04-30 | Buy |
| Chem-Impex | 45975 | 4-Bromo-2,5-difluoroaniline ≥98%(GC) | 112279-60-4 | 1G | $24.9 | 2026-05-19 | Buy |
4-BROMO-2,5-DIFLUOROANILINE Chemical Properties,Uses,Production
Chemical Properties
White solid
Synthesis
367-30-6
112279-60-4
Example 14 Preparation of 4-bromo-2,5-difluoroaniline: To a stirred mixture of 100 g of 2,5-difluoroaniline and 1150 mL of acetic acid (AcOH) was slowly added 40.2 mL of bromine (Br2) in 350 mL of acetic acid (AcOH) over a period of 1.3 h. The reaction temperature was maintained at a temperature of between 15 °C and 20 °C. The reaction was carried out over a period of 2.3 hours. Upon completion of the reaction, the resulting pink suspension was continued to be stirred for 30 minutes, followed by vacuum evaporation to remove the solvent. The residue was alkalized with 50% sodium hydroxide (NaOH) solution (ice was added during the process to maintain the temperature below 35°C). The free base was extracted with 1 L of dichloromethane (CH2Cl2), and the extract was washed with 2 x 100 mL of water (H2O), dried over anhydrous sodium sulfate (Na2SO4), and finally the solvent was evaporated under vacuum to afford 157 g (97.5% yield) of the target product 4-bromo-2,5-difluoroaniline, with melting points ranging from 73°C to 75°C. Mass spectrometry analysis showed the M+1 ion peaks at 208 and 210.
References
[1] Patent: EP224001, 1991, B1
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 43 - 64
[3] Journal of Materials Chemistry, 2004, vol. 14, # 11, p. 1731 - 1743
[4] Patent: EP329752, 1989, A1
[5] Patent: WO2013/142266, 2013, A1. Location in patent: Paragraph 00498
4-BROMO-2,5-DIFLUOROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| HANGZHOU HAILAN CHEMICAL CO.,LTD. | +86-57156122185 +86-15967590394 | sales@hailan-chem.com | China | 2961 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
View Lastest Price from 4-BROMO-2,5-DIFLUOROANILINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 4-BROMO-2,5-DIFLUOROANILINE
112279-60-4
|
1kg | 99%min | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. | ||
 |
2026-03-20 | 4-BROMO-2,5-DIFLUOROANILINE
112279-60-4
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2019-07-12 | 4-BROMO-2,5-DIFLUOROANILINE
112279-60-4
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-BROMO-2,5-DIFLUOROANILINE
112279-60-4
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-
- 4-BROMO-2,5-DIFLUOROANILINE
112279-60-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-BROMO-2,5-DIFLUOROANILINE
112279-60-4
- $1.00
- 99%
- Career Henan Chemical Co
112279-60-4(4-BROMO-2,5-DIFLUOROANILINE)Related Search:
1of4
