LINDERANE
- CAS No.
- 13476-25-0
- Chemical Name:
- LINDERANE
- Synonyms
- linerane;LINDERANE;Linderane-RM;LINDERANE(RG);wuyaomineizhi;Linderane ,98%;Linderane, 98%, from Lindera aggregata (Sims) Kosterm.;(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one;(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-10,1a-(epoxymethano)-2H-oxireno[4,5]cyclodeca[1,2-b]furan-12-one;2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one,3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-
- CBNumber:
- CB9243408
- Molecular Formula:
- C15H16O4
- Molecular Weight:
- 260.29
- MDL Number:
- MFCD07781424
- MOL File:
- 13476-25-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Linderane phyproof? Reference Substance | PHL80489 | 10mg | $499 |
| Linderane | 27479 | 5mg | $44 |
| Linderane | 27479 | 10mg | $78 |
| Linderane | 27479 | 25mg | $151 |
| Linderane | 27479 | 50mg | $278 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| HS Code | 29322090 |
LINDERANE price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL80489 | Linderane phyproof? Reference Substance | 13476-25-0 | 10mg | $499 | 2025-07-31 | Buy |
| Cayman Chemical | 27479 | Linderane | 13476-25-0 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 27479 | Linderane | 13476-25-0 | 10mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 27479 | Linderane | 13476-25-0 | 25mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 27479 | Linderane | 13476-25-0 | 50mg | $278 | 2024-03-01 | Buy |
LINDERANE Chemical Properties,Uses,Production
Description
Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.
Uses
Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.
Definition
ChEBI: Linderane is a member of dioxanes.
IC 50
CYP2
References
[1] HUI WANG. Mechanism-based inactivation of CYP2C9 by linderane.[J]. Xenobiotica, 2015, 45 12: 1037-1046. DOI: 10.3109/00498254.2015.1041002
[2] WEI XIE. Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3.[J]. Frontiers in Pharmacology, 2018: 476. DOI: 10.3389/fphar.2018.00476
LINDERANE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
View Lastest Price from LINDERANE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-11 | Linderane
13476-25-0
|
US $40.00-129.00 / mg | 98.25% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Linderane
13476-25-0
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-24 | Linderane
13476-25-0
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
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