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2-chloro-Thiazolo[4,5-b]pyridine

2-chloro-Thiazolo[4,5-b]pyridine Structure
2-chloro-Thiazolo[4,5-b]pyridine structure
CAS No.
152170-30-4
Chemical Name:
2-chloro-Thiazolo[4,5-b]pyridine
Synonyms
2-chlorothiazolo[4;2-Chlorthiazolo[4,5-b]pyridine;2-chloro-Thiazolo[4,5-b]pyridine;Thiazolo[4,5-b]pyridine, 2-chloro-
CBNumber:
CB92473344
Molecular Formula:
C6H3ClN2S
Molecular Weight:
170.62
MDL Number:
MFCD12828130
MOL File:
152170-30-4.mol
MSDS File:
SDS
Last updated:2026-05-28 05:14:53
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2-chloro-Thiazolo[4,5-b]pyridine Properties

Boiling point 263.5±13.0 °C(Predicted)
Density 1.531±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.95±0.50(Predicted)
Appearance Light brown to brown Solid
InChI InChI=1S/C6H3ClN2S/c7-6-9-5-4(10-6)2-1-3-8-5/h1-3H
InChIKey RSDZXVRUWGEPQG-UHFFFAOYSA-N
SMILES C12N=C(Cl)SC1=CC=CN=2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H332-H335-H302-H312-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2934999090

2-chloro-Thiazolo[4,5-b]pyridine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR903587 2-Chlorothiazolo[4,5-b]pyridine 97% 152170-30-4 250mg $81 2026-06-04 Buy
Apolloscientific OR903587 2-Chlorothiazolo[4,5-b]pyridine 97% 152170-30-4 1g $142 2026-06-04 Buy
Matrix Scientific 073760 2-Chlorothiazolo[4,5-b]pyridine hydrochloride 152170-30-4 250.00mg $145 2026-05-18 Buy
Matrix Scientific 073760 2-Chlorothiazolo[4,5-b]pyridine hydrochloride 152170-30-4 1.00g $363 2026-05-18 Buy
Matrix Scientific 073760 2-Chlorothiazolo[4,5-b]pyridine hydrochloride 152170-30-4 5.00g $1024 2026-05-18 Buy
Product number Packaging Price Buy
OR903587 250mg $81 Buy
OR903587 1g $142 Buy
073760 250.00mg $145 Buy
073760 1.00g $363 Buy
073760 5.00g $1024 Buy

2-chloro-Thiazolo[4,5-b]pyridine Chemical Properties, Uses, Production

Synthesis

thiazolo[4,5-b]pyridine-2(3H)-thione

99158-61-9

2-chloro-Thiazolo[4,5-b]pyridine

152170-30-4

The general procedure for the synthesis of 2-chlorothiazolo[4,5-b]pyridine from thiazolo[4,5-b]pyridine-2(3H)-thione was as follows: sulfuryl chloride (3.32 mL, 40.8 mmol) was slowly added to a dichloromethane (0.5 mL) suspension of thiazolo[4,5-b]pyridine-2-thiol (343 mg, 2.039 mmol). The reaction mixture was stirred at 50 °C for 2 h, followed by continued stirring at room temperature overnight. Upon completion of the reaction, ice water was added to the yellow suspension and stirred at room temperature for 15 minutes to quench the excess sulfuryl chloride. Subsequently, the pH was adjusted to 10-12 by adding ethyl acetate (EtOAc) and 4.0 N sodium hydroxide (NaOH) solution.The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, the crude product was dissolved in a small amount of chloroform and purified by column chromatography on silica gel (12 g silica gel), eluting first with 5% eluent for 3 min and then using a 12% gradient elution (5% to 60%). The fractions containing the target product were combined and concentrated under reduced pressure to give Intermediate 9A (265 mg, 1.553 mmol, 76% yield) as a white solid. The structure of the product was confirmed by 1H NMR (500 MHz, chloroform-d): δ 8.76 (dd, J = 5.0, 1.7 Hz, 1H), 8.19 (dd, J = 8.0, 1.7 Hz, 1H), 7.39 (dd, J = 8.0, 4.7 Hz, 1H); LC-MS analysis (Method A): retention time (RT) = 1.22 min, mass spectrum (ESI) m/z: 171 and 173 ([M + H]+).

References

[1] Patent: WO2018/13774, 2018, A1. Location in patent: Page/Page column 307
[2] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 92

2-chloro-Thiazolo[4,5-b]pyridine Preparation Products And Raw materials

Raw materials

thiazolo[4,5-b]pyridine-2(3H)-thione Sulfuryl chloride Dichloromethane

Preparation Products

2-chloro-Thiazolo[4,5-b]pyridine Suppliers

Global Suppliers ( 66)
Supplier Tel Email Country ProdList Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 981 58
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
skychemical Co.Ltd 021-20958197 20965099 sales@skychemical.com China 1182 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
Shanghai Keepontech Co.,Ltd 021-54849683 13601642561 sales@keepontech.com China 998 59
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
Shanghai Aspire Biological Technology Co., Ltd. 021-61317773/021-31606483/2934163037 sales@aspirebio.com China 255 58
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 02161555100 China 820 58
Supplier Advantage
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
Shangchem Co., Ltd. 52
Pure Chemistry Scientific Inc. 62
skychemical Co.Ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai yirong biology science and technology co., ltd 60
Shanghai Keepontech Co.,Ltd 59
Shanghai Worldyang Chemical Co.,Ltd. 58
Shanghai Aspire Biological Technology Co., Ltd. 58
ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. 58

View Latest Price from 2-chloro-Thiazolo[4,5-b]pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-chloro-Thiazolo[4,5-b]pyridine pictures 2020-01-03 2-chloro-Thiazolo[4,5-b]pyridine
152170-30-4
 $6.60 1KG 97%-99% 1kg -1000kg Career Henan Chemical Co

2-chloro-Thiazolo[4,5-b]pyridine Spectrum

2-chloro-Thiazolo[4,5-b]pyridine(152170-30-4)1HNMR

152170-30-4 (2-chloro-Thiazolo[4,5-b]pyridine) Related Search:

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Thiazolo[4,5-b]pyridine, 2-chloro- 2-chloro-Thiazolo[4,5-b]pyridine 2-Chlorthiazolo[4,5-b]pyridine 2-chlorothiazolo[4 152170-30-4 Heterocycle-Pyridine series