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ChemicalBook >> CAS DataBase List >>N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Structure
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine structure
CAS No.
881202-45-5
Chemical Name:
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
Synonyms
CS-389;SerdeMetan;JNJ 26854165;JNJ-26854165, >=98%;Serdemetan(JNJ 26854165);JNJ-26854165 (SerdeMetan);Serdemetan, 10 mM in DMSO;JNJ 26854165; JNJ26854165; JNJ-26854165;N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-Benzene diamine;n-[2-(1h-indol-3-yl)ethyl]-n'-(4-pyridinyl)-1,4-benzenediamine
CBNumber:
CB92484733
Molecular Formula:
C21H20N4
Molecular Weight:
328.41
MDL Number:
MFCD16620518
MOL File:
881202-45-5.mol
MSDS File:
SDS
Last updated:2025-09-22 14:50:28
Product description Number Pack Size Price
JNJ-26854165 ≥98% 16259 1mg $37
JNJ-26854165 ≥98% 16259 5mg $121
JNJ-26854165 ≥98% 16259 10mg $213
JNJ-26854165 ≥98% 16259 25mg $442
JNJ26854165 J211343 10mg $230
More product size
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N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Properties

storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
form solid
color Light brown to brown
InChI InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKey CEGSUKYESLWKJP-UHFFFAOYSA-N
SMILES C1(NCCC2C3=C(NC=2)C=CC=C3)=CC=C(NC2C=CN=CC=2)C=C1
FDA UNII ID6YB4W3V8
NCI Drug Dictionary serdemetan
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29339900

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16259 JNJ-26854165 ≥98% 881202-45-5 1mg $37 2024-03-01 Buy
Cayman Chemical 16259 JNJ-26854165 ≥98% 881202-45-5 5mg $121 2024-03-01 Buy
Cayman Chemical 16259 JNJ-26854165 ≥98% 881202-45-5 10mg $213 2024-03-01 Buy
Cayman Chemical 16259 JNJ-26854165 ≥98% 881202-45-5 25mg $442 2024-03-01 Buy
TRC J211343 JNJ26854165 881202-45-5 10mg $230 2021-12-16 Buy
Product number Packaging Price Buy
16259 1mg $37 Buy
16259 5mg $121 Buy
16259 10mg $213 Buy
16259 25mg $442 Buy
J211343 10mg $230 Buy

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Chemical Properties,Uses,Production

Uses

JNJ 26854165 is a p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor.

Biological Activity

jnj-26854165, also named as serdemetan, is originally developed as an activator of p53, is now regarded as a novel oral human double minute-2 (hdm-2) ubiquitin ligase antagonist. it can increase the level of hdm-2 client proteins, such as p53, by inhibiting the association of hdm-2-client protein complex with the proteosome. it is demonstrated potent anti-proliferative and apoptosis-inducing activity of jnj-26854165 in a broad range of p53 wild type and mutant tumor models. in vivo, jnj-26854165 may induce important differences in efs distribution when comparing to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable all xenografts.j. tabernero, l. dirix, p. schoffski, a. cervantes, j. capdevila, j. baselga, l. van beijsterveldt, h. winkler, s. kraljevic and s. h. zhuang. phase i pharmacokinetic (pk) and pharmacodynamic (pd) study of hdm-2 antagonist jnj-26854165 in patients with advanced refractory solid tumors. journal of clinical oncology (meeting abstracts) may 2009 vol. 27 no. 15s 3514malcolm a. smith, richard gorlick, e. anders kolb, richard lock, hernan carol, john m. maris, stephen t. keir, christopher l. morton, c. patrick reynolds, min h. kang, janine arts, tarig bashir, michel janicot, raushan t. kurmasheva, peter j. houghton. initial testing of jnj-26854165 (serdemetan) by the pediatric preclinical testing program. pediatric blood & cancer. volume 59, issue 2, pages 329–332, august 2012.

target

HDM2

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Preparation Products And Raw materials

Raw materials

Preparation Products

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Suppliers

Global( 156)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 8026 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		027-88013699 17354350817 Ryan@jiutian-bio.com China 5949 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		58

View Lastest Price from N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Serdemetan pictures 2025-09-22 Serdemetan
881202-45-5
 US $39.00-97.00 / mg 97.13% 10g TargetMol Chemicals Inc.
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine pictures 2025-06-25 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
881202-45-5
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine pictures 2019-09-04 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
881202-45-5
 US $5.00 / KG 1KG 99% 1ton Career Henan Chemical Co
  • Serdemetan pictures
  • Serdemetan
    881202-45-5
  • US $39.00-97.00 / mg
  • 97.13%
  • TargetMol Chemicals Inc.

881202-45-5(N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine)Related Search:

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JNJ-7706621 JNJ 63533054 JNJ-26481585 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide JNJ 31020028
JNJ-632 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide TENOVIN-1 MK-1775 MK-2206 2HCl
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CS-389 JNJ 26854165; JNJ26854165; JNJ-26854165 JNJ 26854165 SerdeMetan JNJ-26854165 (SerdeMetan) JNJ 26854165 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine JNJ 26854165 JNJ-26854165, >=98% N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-Benzene diamine Serdemetan(JNJ 26854165) 1,4-Benzenediamine, N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl- N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine ISO 9001：2015 REACH n-[2-(1h-indol-3-yl)ethyl]-n'-(4-pyridinyl)-1,4-benzenediamine Serdemetan, 10 mM in DMSO N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine 881202-45-5 Inhibitors Inhibitor