3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
- CAS No.
- 1083057-14-0
- Chemical Name:
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
- Synonyms
- tert-Butyl 3-(6-aMino-3-Methylpyridin-2-yl)benzoate;EOS-61004;VX-809 intermediate;tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoat;3-(6-amino-3-methylpyridine-2-yl) tert-butyl benzoate;3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester;3-(6-Amino-3-methyl-pyridin-2-yl)-benzoic acid tert-butyl es...;Tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate(For export only);Benzoic acid, 3-(6-aMino-3-Methyl-2-pyridinyl)-, 1,1-diMethylethyl ester
- CBNumber:
- CB92489657
- Molecular Formula:
- C17H20N2O2
- Molecular Weight:
- 284.35
- MDL Number:
- MFCD16659611
- MOL File:
- 1083057-14-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| REACH Registrations | Active |
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 306466 | tert-Butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate | 1083057-14-0 | 250.00mg | $28 | 2026-05-19 | Buy |
| Matrix Scientific | 306466 | tert-Butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate | 1083057-14-0 | 1.00g | $58 | 2026-05-19 | Buy |
| Matrix Scientific | 306466 | tert-Butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate | 1083057-14-0 | 5.00g | $254 | 2026-05-19 | Buy |
| Synthonix | B58994 | tert-Butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate 98% | 1083057-14-0 | 100mg | $26 | 2026-05-06 | Buy |
| Synthonix | B58994 | tert-Butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate 98% | 1083057-14-0 | 250mg | $32 | 2026-05-06 | Buy |
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Chemical Properties, Uses, Production
Synthesis
1083057-13-9
1083057-14-0
The general procedure for the synthesis of tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate from 2-(3-(tert-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide is as follows: a mixture of 2-(3-(tert-butoxycarbonyl)phenyl)-3-methylpyridine-1-oxide (1 eq.) and pyridine (4 eq.) in acetonitrile (8 vol.) was heated to 70 °C. A solution of methylsulfonic anhydride (1.5 eq.) in acetonitrile (2 vol.) was slowly added through the addition funnel over 50 min, and the reaction temperature was controlled below 75 °C. After the addition was completed, stirring of the reaction mixture was continued for 0.5 hours. The reaction mixture was then cooled to room temperature. Ethanolamine (10 equivalents) was added through the addition funnel and after stirring the reaction for 2 hours, water (6 volumes) was added and the mixture was cooled to 10°C. After continued stirring for not less than 3 hours, the solid product was collected by filtration. The solid was washed sequentially with water (3 volumes), a 2:1 acetonitrile/water mixture (3 volumes) and acetonitrile (2 x 1.5 volumes). The solid was dried in a vacuum oven at 50 °C to constant weight (less than 1% change in weight) and kept under a slight stream of nitrogen to give tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate as a reddish yellow solid in 53% yield.
References
[1] Patent: WO2009/76142, 2009, A2. Location in patent: Page/Page column 54
[2] Patent: WO2009/73757, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: WO2010/37066, 2010, A2. Location in patent: Page/Page column 12; 28-29
[4] Patent: US2013/186801, 2013, A1. Location in patent: Paragraph 0371; 0372
[5] Patent: WO2013/185112, 2013, A1. Location in patent: Paragraph 00569
3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| China Shenyang Tyschem CO. ,LTD | +86-024-83607930 18640359690 | sales@honghuchem.com | China | 256 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| ShangHai Onsyn-Chemical Technology Co., Ltd. | 13917628136 15900795984 | 572350448@qq.com | China | 259 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
View Latest Price from 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-25 | 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
183057-14-0
|
$2.00-6.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2020-01-13 | 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
1083057-14-0
|
1KG | 98%; 99% | 500g； 1kg; 25kg | Career Henan Chemical Co | ||
 |
2019-12-20 | 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
1083057-14-0
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
183057-14-0
- $2.00-6.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
1083057-14-0
- $0.01
- 98%; 99%
- Career Henan Chemical Co
-
- 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
1083057-14-0
- $1.00
- 99%
- Career Henan Chemical Co
