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ChemicalBook >> CAS DataBase List >>6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Structure
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole structure
CAS No.
1231930-33-8
Chemical Name:
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Synonyms
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole;Abemaciclib Impurity 1;Abemaciclib Impurity N4;Abemaciclib Impurity 1 D5;Abemaciclib Impurity 1 D12;6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)-;6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole;6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
CBNumber:
CB92500134
Molecular Formula:
C11H12BrFN2
Molecular Weight:
271.13
MDL Number:
MFCD16660227
MOL File:
1231930-33-8.mol
MSDS File:
SDS
Last updated:2026-01-21 09:55:50
Product description Number Pack Size Price
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1h-benzo[d]imidazole B692398 500mg $45
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 95+% 090163 1g $89
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole X9551 1g $158
6-Bromo-4-fluoro-1-isopropyl-2-methyl-benzimidazole PC28238 1g $235
6-BROMO-4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOLE 95.00% HCH0367778 5MG $501.69
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6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Properties

Boiling point 353.4±22.0 °C(Predicted)
Density 1.49
storage temp. Sealed in dry,Room Temperature
pka 3.48±0.10(Predicted)
Appearance Off-white to yellow Solid
InChI InChI=1S/C11H12BrFN2/c1-6(2)15-7(3)14-11-9(13)4-8(12)5-10(11)15/h4-6H,1-3H3
InChIKey SJQZRZLUEGCXFN-UHFFFAOYSA-N
SMILES C1(C)N(C(C)C)C2=CC(Br)=CC(F)=C2N=1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code  2933998090

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B692398 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1h-benzo[d]imidazole 1231930-33-8 500mg $45 2021-12-16 Buy
Matrix Scientific 090163 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 95+% 1231930-33-8 1g $89 2021-12-16 Buy
AK Scientific X9551 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 1231930-33-8 1g $158 2021-12-16 Buy
Apolloscientific PC28238 6-Bromo-4-fluoro-1-isopropyl-2-methyl-benzimidazole 1231930-33-8 1g $235 2021-12-16 Buy
American Custom Chemicals Corporation HCH0367778 6-BROMO-4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOLE 95.00% 1231930-33-8 5MG $501.69 2021-12-16 Buy
Product number Packaging Price Buy
B692398 500mg $45 Buy
090163 1g $89 Buy
X9551 1g $158 Buy
PC28238 1g $235 Buy
HCH0367778 5MG $501.69 Buy

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Chemical Properties,Uses,Production

Uses

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is a pharmaceutical intermediate. It can be used in the preparation of Abemaciclib, a kinase inhibitor for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer who have experienced disease progression following endocrine therapy and prior chemotherapy.

Hazard

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole causes skin irritation and serious eye irritation. It may cause respiratory irritation.

Flammability and Explosibility

Not classified

Synthesis

EthaniMidaMide, N-(4-broMo-2,6-difluorophenyl)-N'-(1-Methylethyl)-

1231930-29-2

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

1231930-33-8

The general procedure for the synthesis of 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole using (E)-N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine as starting material was as follows: potassium tert-butanolate (6.9 kg) was added batchwise to a (E)-N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine (16.2 kg) N-methylformamide (76 kg) solution while controlling the reaction temperature below 30°C. The reaction mixture was heated to 70-75°C until the completion of the reaction was monitored by HPLC. The reaction solution was then cooled to 20-30°C and the reaction was quenched by addition of water (227 kg). Extraction was carried out with methyl tert-butyl ether (37 x 4 kg) and the combined organic phases were washed with brine (49 x 2 kg). The organic phase was concentrated to 25-30 L, n-hexane (64 kg) was added and the resulting slurry was filtered to give 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[D]imidazole (11 kg). Mass spectrum (ES+): m/z = 272 (M + H)+. For further purification, the crude product was dissolved in dichloromethane, filtered through silica gel and Celite pads, and finally recrystallized from a mixed solvent of methyl tert-butyl ether/hexane.

References

[1] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 10
[2] Patent: WO2015/130540, 2015, A1. Location in patent: Page/Page column 22

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole synthesis

1301214-70-9
67-64-1
1231930-33-8
Synthesis of 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole from 1H-Benzimidazole, 5-bromo-7-fluoro-2-methyl- and Acetone

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Preparation Products And Raw materials

Raw materials

1H-Benzimidazole, 5-bromo-7-fluoro-2-methyl- Ethanimidamide,N-(1-methylethyl)- EthaniMidaMide, N-(4-broMo-2,6-difluorophenyl)-N'-(1-Methylethyl)- 4-Bromo-2,6-difluoroaniline N-Isopropylacetamide
Acetone

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Preparation Products

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Suppliers

Global( 255)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Zhonghan Chemical Technology Co., LTD. 		+undefined15066662237 3281004549@qq.com China 291 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29821 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Jinan Zhonghan Chemical Technology Co., LTD. 		58
Henan Fengda Chemical Co., Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole pictures 2025-12-01 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-33-8
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole pictures 2025-11-18 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-33-8
 US $1.10 / g 1g 99.0% Min 100 Tons Dideu Industries Group Limited
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole pictures 2025-09-25 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-33-8
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

1231930-33-8(6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole)Related Search:

6-BroMo-4-fluoro-3-Methylindazole PERFLUOROPOLYALKYL ETHER GALDEN (TM) HT70 Hexafluoroisopropyl methyl ether 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
2-bromo-8-fluoro-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one PF-01367338 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

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6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole 1H-BenziMidazole, 6-broMo-4-fluoro-2-Methyl-1-(1-Methylethyl)- 6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole 6-bromo-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole 6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole Abemaciclib Impurity 1 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole ISO 9001：2015 REACH Abemaciclib Impurity 1 D12 Abemaciclib Impurity 1 D5 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole 6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)- 5-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 5-bromo-7-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Abemaciclib Impurity N4 1231930-33-8 1230930-33-8 API