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KU57788(NU7441)

KU57788(NU7441) structure

CAS No.: 503468-95-9

Chemical Name:: KU57788(NU7441)

Synonyms: CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU-57788, 10 mM in DMSO;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441

CBNumber:: CB92500947

Molecular Formula:: C25H19NO3S

Molecular Weight:: 413.49

MDL Number:: MFCD11983069

MOL File:: 503468-95-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-21 10:31:43

Product description	Number	Pack Size	Price
NU 7441 ≥98%	14881	5mg	$48
NU 7441 ≥98%	14881	10mg	$85
NU 7441 ≥98%	14881	25mg	$154
NU 7441 ≥98%	14881	5mg	$43
NU 7441 ≥98%	14881	1mg	$26
More product size

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KU57788(NU7441) Properties

Melting point	220-221 °C
Boiling point	646.9±55.0 °C(Predicted)
Density	1.376±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	Soluble in DMSO (up to 10 mg/ml with warming).
pka	0.51±0.20(Predicted)
form	solid
color	Off-white to beige
Stability	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI	1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChIKey	JAMULYFATHSZJM-UHFFFAOYSA-N
SMILES	[s]1c2c(c6c1cccc6)cccc2c3c4[o]c(c[c](c4ccc3)=O)N5CCOCC5
FDA UNII	XF6ZJD5WGU
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

KU57788(NU7441) price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14881	NU 7441 ≥98%	503468-95-9	5mg	$48	2026-04-30	Buy
Cayman Chemical	14881	NU 7441 ≥98%	503468-95-9	10mg	$85	2026-04-30	Buy
Cayman Chemical	14881	NU 7441 ≥98%	503468-95-9	25mg	$154	2026-04-30	Buy
Cayman Chemical	14881	NU 7441 ≥98%	503468-95-9	5mg	$43	2024-03-01	Buy
Cayman Chemical	14881	NU 7441 ≥98%	503468-95-9	1mg	$26	2023-06-20	Buy

Product number	Packaging	Price	Buy
14881	5mg	$48	Buy
14881	10mg	$85	Buy
14881	25mg	$154	Buy
14881	5mg	$43	Buy
14881	1mg	$26	Buy

KU57788(NU7441) Chemical Properties,Uses,Production

Description

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC₅₀ value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC₅₀ values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

Uses

A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.

Uses

A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.

Definition

ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.

IC 50

DNA-PK: 14 nM (IC₅₀); mTOR: 1.7 μM (IC₅₀); PI3K: 5.0 μM (IC₅₀); CRISPR/Cas9

storage

Store at +4°C

References

[1] JUSTIN J.J. LEAHY . Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 24: Pages 6083-6087. DOI:10.1016/j.bmcl.2004.09.060
[2] IAN R. HARDCASTLE. Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach[J]. Journal of Medicinal Chemistry, 2005, 48 24: 7829-7846. DOI:10.1021/jm050444b
[3] YAN ZHAO. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.[J]. Cancer research, 2006, 66 10: 5354-5362. DOI:10.1158/0008-5472.can-05-4275
[4] WOJCIECH M CISZEWSKI. DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin.[J]. Breast Cancer Research and Treatment, 2014, 143 1: 47-55. DOI:10.1007/s10549-013-2785-6
[5] CHUANJIE YANG. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells.[J]. Cellular Physiology and Biochemistry, 2016, 38 5: 1897-1905. DOI:10.1159/000445551
[6] WEI GENG. DNA‑PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy.[J]. Oncology reports, 2019, 42 2: 561-570. DOI:10.3892/or.2019.7187

KU57788(NU7441) Preparation Products And Raw materials

Raw materials

Preparation Products

KU57788(NU7441) Suppliers

Global( 163)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from KU57788(NU7441) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-21	KU-57788 503468-95-9	US $34.00-90.00 / mg		99.91%	10g	TargetMol Chemicals Inc.
	2019-07-06	KU57788(NU7441) 503468-95-9	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

KU-57788
503468-95-9
US $34.00-90.00 / mg
99.91%
TargetMol Chemicals Inc.

KU57788(NU7441)
503468-95-9
US $2.00 / kg
99%
Career Henan Chemical Co

KU57788(NU7441) Spectrum

KU57788(NU7441)(503468-95-9)¹HNMR

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1of3

KU57788(NU7441) NU 7441 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one NU7441 (KU-57788);KU 57788; NU-7441 KU 57788 NU-7441 (KU-57788) 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441 NU 7441 (This product is only available in Japan.) CS-181 NU 7441 - KU 47788 NU7441;KU57788;NU 7441 (KU 57788) 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one KU57788(NU7441) USP/EP/BP KU-57788, 10 mM in DMSO 503468-95-9 Inhibitors Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds