N-Tosyl-L-alanine
- CAS No.
- 21957-58-4
- Chemical Name:
- N-Tosyl-L-alanine
- Synonyms
- N-Tosyl-L-Ala;Tos-Ala-OH,97%;N-Tosyl-L-alanine USP/EP/BP;N-(Toluene-4-sulfonyl)-L-alanine;N-[(4-Methylphenyl)sulfonyl]-L-alanine;L-Alanine,N-[(4-methylphenyl)sulfonyl]-;(S)-2-(4-MethylphenylsulfonaMido)propanoic acid;(2S)-2-(4-methylbenzenesulfonamido)propanoic acid;(2S)-2-[(4-methylphenyl)sulfonylamino]propanoicaci;(2S)-2-[[(4-Methylphenyl)sulfonyl]aMino]propanoic Acid
- CBNumber:
- CB92505694
- Molecular Formula:
- C10H13NO4S
- Molecular Weight:
- 243.28
- MDL Number:
- MFCD02259513
- MOL File:
- 21957-58-4.mol
| Product description | Number | Pack Size | Price |
| Tos-Ala-OH AldrichCPR | CDS004033 | 250MG | $73.1 |
| Tos-Ala-OH | M3484 | 5G | $40 |
| Tos-Ala-OH | M3484 | 25G | $119 |
| N-Tosyl-L-alanine | T550525 | 500mg | $90 |
| N-Tosyl-L-alanine | 1110AB | 100g | $107 |
| Melting point | 138-139℃ |
|---|---|
| Boiling point | 428.9±55.0 °C(Predicted) |
| Density | 1.319 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, Methanol |
| form | Solid |
| pka | 3.45±0.10(Predicted) |
| color | White |
| optical activity | Consistent with structure |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
N-Tosyl-L-alanine price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS004033 | Tos-Ala-OH AldrichCPR | 21957-58-4 | 250MG | $73.1 | 2025-07-31 | Buy |
| TCI Chemical | M3484 | Tos-Ala-OH | 21957-58-4 | 5G | $40 | 2025-07-31 | Buy |
| TCI Chemical | M3484 | Tos-Ala-OH | 21957-58-4 | 25G | $119 | 2025-07-31 | Buy |
| TRC | T550525 | N-Tosyl-L-alanine | 21957-58-4 | 500mg | $90 | 2021-12-16 | Buy |
| AK Scientific | 1110AB | N-Tosyl-L-alanine | 21957-58-4 | 100g | $107 | 2021-12-16 | Buy |
N-Tosyl-L-alanine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
N-Tosyl-L-alanine (cas# 21957-58-4) is a compound useful in organic synthesis.
reaction suitability
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis
Synthesis
56-41-7
98-59-9
4816-81-3
GENERAL STEPS: The synthesis was carried out using the N-toluene sulfonylation method reported in the literature. In a round-bottomed flask, 2.4 equivalents of Na2CO3 was dissolved in water at 70 °C (concentration 0.66 mol/L). Subsequently, 1.0 equiv. of L-alanine was added, followed by the slow addition of 1.4 equiv. of p-toluenesulfonyl chloride. The resulting suspension was stirred and reacted at 70 °C for 40 min, followed by warming to 85 °C and continued stirring for 5 min. Upon completion of the reaction, the reaction mixture was filtered directly and the solids were washed with hot water at 85°C. The filtrate was cooled to room temperature and acidified with 6 M aqueous HCl to pH=1. The precipitated solid product was collected by filtration and dried under vacuum. The resulting 2-(4-methylphenylsulfonamido)propionic acid was used for subsequent experiments without further purification.
References
[1] RSC Advances, 2015, vol. 5, # 24, p. 18751 - 18760
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 29, p. 4006 - 4012
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 21, p. 3451 - 3460
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2000, vol. 55, # 2, p. 203 - 207
[5] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6632 - 6638
N-Tosyl-L-alanine Preparation Products And Raw materials
N-Tosyl-L-alanine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20284 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
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| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
