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Pevonedistat

Pevonedistat Structure
Pevonedistat structure
CAS No.
905579-51-3
Chemical Name:
Pevonedistat
Synonyms
MLN 4924;CS-821;TAK-924;Pevonedistat;mln4924 Free Base;PEVONEDISTAT;MLN-4924;MLN4924 (Pevonedistat);Pevonedistat (TAK-924);Pevonedistat, 10 mM in DMSO;Pevonedistat (MLN4924) ，S7109
CBNumber:
CB92510096
Molecular Formula:
C21H25N5O4S
Molecular Weight:
443.52
MDL Number:
MFCD17215201
MOL File:
905579-51-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
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Pevonedistat Properties

Melting point 161-163°C
Boiling point 721.0±70.0 °C(Predicted)
Density 1.62
storage temp. -20°C Freezer
solubility Soluble in DMSO (up to 10 mg/ml).
form solid
pka 9.35±0.70(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey MPUQHZXIXSTTDU-QXGSTGNESA-N
SMILES S(N)(OC[C@@H]1C[C@@H](N2C3C(C=C2)=C(N[C@@H]2C4=C(C=CC=C4)CC2)N=CN=3)C[C@@H]1O)(=O)=O
NCI Dictionary of Cancer Terms pevonedistat
FDA UNII S3AZD8D215
NCI Drug Dictionary pevonedistat

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
NFPA 704
0
2 0

Pevonedistat price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15217 MLN4924 ≥98% 905579-51-3 1mg $58 2026-04-30 Buy
Cayman Chemical 15217 MLN4924 ≥98% 905579-51-3 5mg $115 2026-04-30 Buy
Cayman Chemical 15217 MLN4924 ≥98% 905579-51-3 10mg $201 2026-04-30 Buy
TRC TRC-M425100-1MG MLN 4924 905579-51-3 1mg $117 2026-06-03 Buy
Usbiological 017703 MLN 4924 905579-51-3 1mg $382 2026-06-03 Buy
Product number Packaging Price Buy
15217 1mg $58 Buy
15217 5mg $115 Buy
15217 10mg $201 Buy
TRC-M425100-1MG 1mg $117 Buy
017703 1mg $382 Buy

Pevonedistat Chemical Properties, Uses, Production

Description

MLN4924 (905579-51-3) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor.1It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice.2Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma.3Modulates tumor microenvironment.4Cell permeable.

Chemical Properties

White Solid

Uses

A potent and selective inhibitor of NAE. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. The ubiquitin-proteasome pathway mediates the destruction of unwanted proteins. Potent NAE inhibitor; NEDD8 E1 Activating Enzyme Inhibitor.

Definition

ChEBI: Pevonedistat is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. It has a role as an apoptosis inducer and an antineoplastic agent. It is a pyrrolopyrimidine, a secondary amino compound, a member of cyclopentanols, a sulfamidate and a member of indanes.

Enzyme inhibitor

This first-in-class small molecule inhibitor (FW = 443.52 g/mol; CAS 905579-51-3; Solubility = 10 mg/mL DMSO), also named MLN4924 and [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3- d]pyrimidin-7-yl]-2-hydroxycyclopentyl]sulfamate methyl ester, targets Nedd8 activating enzyme, or NAE (IC50 = 4.7 nM), with much weaker action against UAE (IC50 = 1.5 μM), SAE (IC50 = 8.2 μM), and UBA6 (IC50 = 1.8 μM). In most cancer cells, pevonedistat treatment results in the induction of DNA re-replication, resulting in DNA damage and cell death. MLN4924 also exhibits an alternative mechanism of action. Treatment of activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) cells with pevonedistat resulted in rapid accumulation of pIkBa, decrease in nuclear p65 content, reduction of transcriptional activity of NF-kB (or nuclear factor k-light-chain-enhancer of activated B cells), and G1 arrest, ultimately resulting in apoptosis induction, events consistent with potent NF-kB pathway inhibition. Treatment of germinal-center B cell-like (GCB) DLBCL cells resulted in an increase in cellular Cdt-1 and accumulation of cells in S-phase, consistent with cells undergoing DNA rereplication. Pevonedistat also inhibits Vpx/Vpr-induced SAMHD1 degradation by inhibiting the neddylation of E3 ubiquitin-ligase and blocking SIVmac replication in myeloid cells, therebyindicating the potential efficacy of inhibiting neddylation as an antiretroviral strategy

storage

Store at -20°C

Background

MLN4924 is a potent and selective inhibitor of NEDD8-activating enzyme. The NAE is part of the NEDD8 conjugation pathway that involves the ubiquitin-like NEDD8 protein and cullin-RING ligases. The NAE is responsible for the covalent attachment of NEDD8 to cullin proteins, termed neddylation, resulting in a conformational change within the CRL, analogous to ubiquitination. This is a reversible, multi-step process responsible for cell cycle progression and survival pathways in cancer cells. The inhibition of NAE by MLN4924 induces apoptosis in human tumor cells and reduces human tumor xenograft growth in mice.

References

[1] TERESA A. SOUCY. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer[J]. Nature, 2009, 458 7239: 732-736. DOI:10.1038/nature07884
[2] MICHAEL A MILHOLLEN. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.[J]. Blood, 2010: 1515-1523. DOI:10.1182/blood-2010-03-272567
[3] SHAOLONG ZHOU. Neddylation inhibition upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma[J]. International Journal of Cancer, 2019, 145 3: 763-774. DOI:10.1002/ijc.32379
[4] LISHA ZHOU. Neddylation: a novel modulator of the tumor microenvironment.[J]. Molecular Cancer, 2019: 77. DOI:10.1186/s12943-019-0979-1

Pevonedistat Preparation Products And Raw materials

Raw materials

Preparation Products

Pevonedistat Suppliers

Global Suppliers ( 202)
Supplier Tel Email Country ProdList Advantage
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9711 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Chengdu NoVi Biotechnology Co., Ltd. 028-81458053 novibiotech@163.com sales@novi-biotech.com China 226 55
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Supplier Advantage
ShangHai ChuanQian Chemcial Technique Centre 58
Nantong Hi-Future Biotechnology Co., Ltd 58
Shanghai Chaolan Chemical Technology Center 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Chemsky（shanghai）International Co.,Ltd. 50
Jinan Trio PharmaTech Co., Ltd. 62
Shanghai Topbiochem Technology Co., Ltd 58
Chengdu NoVi Biotechnology Co., Ltd. 55
NCE Biomedical Co.,Ltd. 55

Related articles

View Latest Price from Pevonedistat manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pevonedistat pictures 2026-08-20 Pevonedistat
905579-51-3
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Pevonedistat pictures 2026-07-14 Pevonedistat
905579-51-3
 $48.00-97.00 99.55% 10g TargetMol Chemicals Inc.
Pevonedistat pictures 2024-10-22 Pevonedistat
905579-51-3
 $1.00 1g 85.0-99.8% 20tons Career Henan Chemica Co
  • Pevonedistat pictures
  • Pevonedistat
    905579-51-3
  • $1.10
  • 99.00%
  • Dideu Industries Group Limited
  • Pevonedistat pictures
  • Pevonedistat
    905579-51-3
  • $48.00-97.00
  • 99.55%
  • TargetMol Chemicals Inc.

Pevonedistat Spectrum

Pevonedistat(905579-51-3)1HNMR

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((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)aMino)-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-hydroxycyclopentyl)Methyl sulfaMate [(1S,2S,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]aMino}-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-2-hydroxycyclopentyl]Methyl sulfaMate CS-821 TAK-924 PEVONEDISTAT;MLN-4924 Pevonedistat MLN4924 (Pevonedistat) Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimi MLN 4924 Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester mln4924 Free Base Pevonedistat (MLN-4924,TAK 924) ((1S,2S,4S)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate (1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate Pevonedistat (TAK-924) Pevonedistat ISO 9001：2015 REACH MLN-4924, NEDD8-activating enzyme inhibitor Pevonedistat, 10 mM in DMSO Pevonedistat (MLN4924) ，S7109 5′-O-dimethoxytrityl-2′-O-terbutyldimethylsilyl-3′-N,N-diisopropylcyanoethylphosphoramidite-2′,3',4',5',5''-pentadeuterium-β-D-ribofuranosyl-N4-benzoylcytidine 905579-51-3 C21H25N5O4S Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Inhibitors Intermediates & Fine Chemicals Nucleotides Pharmaceuticals