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ChemicalBook >> CAS DataBase List >>2-Amino-5-bromo-4-methoxybenzoic acid

2-Amino-5-bromo-4-methoxybenzoic acid

2-Amino-5-bromo-4-methoxybenzoic acid Structure
2-Amino-5-bromo-4-methoxybenzoic acid structure
CAS No.
169045-04-9
Chemical Name:
2-Amino-5-bromo-4-methoxybenzoic acid
Synonyms
2-Amino-5-bromo-4-methoxybenzoic acid;Benzoic acid, 2-amino-5-bromo-4-methoxy-;2-Amino-5-bromo-4-methoxybenzoic acid 95+%
CBNumber:
CB92525599
Molecular Formula:
C8H8BrNO3
Molecular Weight:
246.06
MDL Number:
MFCD21868786
MOL File:
169045-04-9.mol
MSDS File:
SDS
Last updated:2026-05-28 05:39:08
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2-Amino-5-bromo-4-methoxybenzoic acid Properties

Melting point 201 °C
Boiling point 363.6±42.0 °C(Predicted)
Density 1.703±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form crystalline powder
pka 4.82±0.10(Predicted)
color Light pink

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P260-P271-P280
HS Code  2922500090

2-Amino-5-bromo-4-methoxybenzoic acid price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth UGA04504 2-Amino-5-bromo-4-methoxybenzoic acid 169045-04-9 10g $519.2 2026-06-05 Buy
Biosynth UGA04504 2-Amino-5-bromo-4-methoxybenzoic acid 169045-04-9 25g $714 2026-06-05 Buy
Biosynth UGA04504 2-Amino-5-bromo-4-methoxybenzoic acid 169045-04-9 50g $1038.5 2026-06-05 Buy
Apolloscientific OR400461 2-Amino-5-bromo-4-methoxybenzoic acid ≥95% 169045-04-9 250mg $55 2026-06-04 Buy
Apolloscientific OR400461 2-Amino-5-bromo-4-methoxybenzoic acid ≥95% 169045-04-9 1g $109 2026-06-04 Buy
Product number Packaging Price Buy
UGA04504 10g $519.2 Buy
UGA04504 25g $714 Buy
UGA04504 50g $1038.5 Buy
OR400461 250mg $55 Buy
OR400461 1g $109 Buy

2-Amino-5-bromo-4-methoxybenzoic acid Chemical Properties,Uses,Production

Synthesis

2-AMINO-4-METHOXY-BENZOIC ACID

4294-95-5

2-Amino-5-bromo-4-methoxybenzoic acid

169045-04-9

2-Amino-4-methoxybenzoic acid (4.00 g, 23.93 mmol) was dissolved in DMF (120 mL) at 0 °C, followed by the addition of N-bromosuccinimide (NBS, 4.68 g, 26.3 mmol). The cooling bath was removed and the reaction mixture was allowed to gradually warm up to room temperature and stirred continuously at this temperature for 1 hour. Upon completion of the reaction, the mixture was re-cooled to 0 °C, saturated sodium sulfite solution (25 mL) was added and stirred for 5 min. The pH of the mixture was adjusted with concentrated hydrochloric acid (~10-15 mL) to 3. The reaction mixture was transferred to a split funnel containing water (100 mL) and extracted with ether (250 mL for the first time and 100 mL for the next 4 times). The organic layers were combined, washed sequentially with water (3 x 50 mL) and brine (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give 2-amino-5-bromo-4-methoxybenzoic acid (5.90 g, 100% yield) as a solid product. The product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 7.78 (s, 1H), 6.43 (s, 1H), 3.81 (s, 3H), 2.90 (s, 1H), 2.74 (s, 1H); MS (ESI) m/e 228.0 [(M+H-H2O), calculated value C8H7BrNO2 228.0].

References

[1] Patent: WO2016/53794, 2016, A1. Location in patent: Page/Page column 111
[2] Patent: US2009/69320, 2009, A1. Location in patent: Page/Page column 68
[3] Patent: WO2014/169167, 2014, A1. Location in patent: Page/Page column 87
[4] Patent: WO2015/17589, 2015, A1. Location in patent: Page/Page column 98

2-Amino-5-bromo-4-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

2-Amino-4-methoxy-benzoic acid N-Bromosuccinimide N,N-Dimethylformamide

Preparation Products

2-Amino-5-bromo-4-methoxy-benzoic acid methyl ester 6-broMo-4-chloro-7-Methoxyquinazoline

2-Amino-5-bromo-4-methoxybenzoic acid Suppliers

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
Amkchem Limited 微信：18019252918 18019252918 sale@amkchem.com China 1886 58
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Supplier Advantage
Amkchem Limited 58
Carbott PharmTech Inc. 56
Adamas Reagent, Ltd. 59
Shanghai Ennopharm Co., Ltd. 65
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55

2-Amino-5-bromo-4-methoxybenzoic acid Spectrum

2-Amino-5-bromo-4-methoxybenzoic acid(169045-04-9)1HNMR2-Amino-5-bromo-4-methoxybenzoic acid(169045-04-9)FT-IR

169045-04-9(2-Amino-5-bromo-4-methoxybenzoic acid)Related Search:

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Benzoic acid, 2-amino-5-bromo-4-methoxy-, ethyl ester

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2-Amino-5-bromo-4-methoxybenzoic acid 2-Amino-5-bromo-4-methoxybenzoic acid 95+% Benzoic acid, 2-amino-5-bromo-4-methoxy- 169045-04-9