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CP466722

CP466722 Structure
CP466722 structure
CAS No.
1080622-86-1
Chemical Name:
CP466722
Synonyms
CS-73;CP466722;CP-466722, >98%;CP-466722;CP466722;CP466722 USP/EP/BP;CP466722 >=98% (HPLC);CP-466722, 10 mM in DMSO;CP466722;CP 466722;CP-466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine
CBNumber:
CB92535567
Molecular Formula:
C17H15N7O2
Molecular Weight:
349.35
MDL Number:
MFCD17392566
MOL File:
1080622-86-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
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CP466722 Properties

Boiling point 642.3±65.0 °C(Predicted)
Density 1.48
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: soluble0.5mg/mL, clear (warmed)
pka 0.00±0.19(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

CP466722 price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1115 CP466722 ≥98% (HPLC) 1080622-86-1 5mg $212 2022-05-15 Buy
Sigma-Aldrich SML1115 CP466722 ≥98% (HPLC) 1080622-86-1 25mg $724 2022-05-15 Buy
Cayman Chemical 25417 CP 466,722 ≥98% 1080622-86-1 1mg $46 2026-04-30 Buy
Cayman Chemical 25417 CP 466,722 ≥98% 1080622-86-1 5mg $202 2026-04-30 Buy
Cayman Chemical 25417 CP 466,722 ≥98% 1080622-86-1 10mg $355 2026-04-30 Buy
Product number Packaging Price Buy
SML1115 5mg $212 Buy
SML1115 25mg $724 Buy
25417 1mg $46 Buy
25417 5mg $202 Buy
25417 10mg $355 Buy

CP466722 Chemical Properties, Uses, Production

Description

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).

Uses

CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase

Definition

ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines.

target

ATM

IC 50

ATM: 4.1 μM (IC50)

References

[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.

CP466722 Preparation Products And Raw materials

Raw materials

Preparation Products

CP466722 Suppliers

Global Suppliers ( 127)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Supplier Advantage
Chembest Research Laboratories Limited 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jinan Trio PharmaTech Co., Ltd. 62
Shanghai civi chemical technology co.,Ltd 52
Beijing HuaMeiHuLiBiological Chemical 58
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
MedChemexpress LLC 58
Guangzhou Isun Pharmaceutical Co., Ltd 55

View Latest Price from CP466722 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CP-466722 pictures 2026-07-14 CP-466722
1080622-86-1
 $68.00-193.00 99.14% 10g TargetMol Chemicals Inc.
CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine pictures 2019-09-06 CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine
1080622-86-1
 $1.00 1ASSAYS 95%~99% Career Henan Chemical Co
  • CP-466722 pictures
  • CP-466722
    1080622-86-1
  • $68.00-193.00
  • 99.14%
  • TargetMol Chemicals Inc.

CP466722 Spectrum

CP466722(1080622-86-1)1HNMR

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CP466722 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP466722;CP 466722;CP-466722 CS-73 CP-466722, >98% 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine CP-466722;CP466722 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine 1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)- CP466722 >=98% (HPLC) CP466722 USP/EP/BP CP-466722, 10 mM in DMSO 1080622-86-1 C17H15N7O2 Inhibitors