2-Cyanotetrahydrofuran
- CAS No.
- 14631-43-7
- Chemical Name:
- 2-Cyanotetrahydrofuran
- Synonyms
- 2-Cyanotetrahydrofuran;tetrahydro-2-Furancarbonitrile;2-Furancarbonitrile, tetrahydro-;2-tetrahydrofuran-2-carbonitrile
- CBNumber:
- CB92546103
- Molecular Formula:
- C5H7NO
- Molecular Weight:
- 97.12
- MDL Number:
- MFCD07787008
- MOL File:
- 14631-43-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H311-H331 |
| Precautionary statements | P261-P280-P301+P310-P311 |
2-Cyanotetrahydrofuran price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 307330 | 2-Cyanotetrahydrofuran | 14631-43-7 | 250.00mg | $56 | 2026-05-19 | Buy |
| Matrix Scientific | 307330 | 2-Cyanotetrahydrofuran | 14631-43-7 | 1.00g | $154 | 2026-05-19 | Buy |
| Matrix Scientific | 307330 | 2-Cyanotetrahydrofuran | 14631-43-7 | 5.00g | $439 | 2026-05-19 | Buy |
| aablocks | AA001DTP | Tetrahydrofuran-2-carbonitrile 95% | 14631-43-7 | 100mg | $23 | 2026-05-28 | Buy |
| aablocks | AA001DTP | Tetrahydrofuran-2-carbonitrile 95% | 14631-43-7 | 250mg | $38 | 2026-05-28 | Buy |
2-Cyanotetrahydrofuran Chemical Properties, Uses, Production
Synthesis
91470-28-9
14631-43-7
General procedure for the synthesis of 2-cyanotetrahydrofuran from tetrahydrofuran-2-carboxamide: Preparation of 2-cyanotetrahydrofuran. Trifluoroacetic anhydride (1.55 g, 7.38 mmol) was slowly added to an anhydrous 1,4-dioxane (10 mL) ice-cold solution (0 °C) of tetrahydrofuran-2-carboxamide (0.77 g, 6.71 mmol) and pyridine (1.06 g, 13.42 mmol) at a rate of one drop every 10 seconds. The addition of trifluoroacetic anhydride was monitored to ensure that the internal temperature was below 5 °C and that the addition was completed within 20 min. The reaction mixture was gradually warmed to room temperature and stirred continuously for 3 hours. Upon completion of the reaction, chloroform (100 mL) was added to the mixture and extracted sequentially with water (30 mL) and saturated aqueous sodium chloride solution (20 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (eluent: hexane to 25% ethyl acetate/hexane gradient elution) to afford 2-cyanotetrahydrofuran (0.51 g, 62% yield) as a colorless oil.1H NMR (CDCl3, 300 MHz) δ: 4.70 (1H, m), 3.96 (2H, m), 2.24 (2H, m), 2.08 (2H, m). m).
References
[1] Patent: US2005/187266, 2005, A1
[2] Patent: WO2004/92145, 2004, A1. Location in patent: Page 137
2-Cyanotetrahydrofuran Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Nanjing ERan Biological Pharmaceutical Co., Ltd. | 13770809694 | googlexu_0114@sina.com | China | 992 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-63315541 13323832564 | 1443871971@qq.com | China | 9896 | 58 |
