6-broMophthalazine-1,4-diol
- CAS No.
- 76240-49-8
- Chemical Name:
- 6-broMophthalazine-1,4-diol
- Synonyms
- 6-Bromo-2,3-dihydrophthalazine-1,4-dione;6-broMophthalazine-1,4-diol;1(2H)-PHTHALAZINE, 7-BROMO-4-HYDROXY;1(2H)-Phthalazinone, 7-bromo-4-hydroxy-
- CBNumber:
- CB92550593
- Molecular Formula:
- C8H5BrN2O2
- Molecular Weight:
- 241.04
- MDL Number:
- MFCD00094997
- MOL File:
- 76240-49-8.mol
- MSDS File:
- SDS
6-broMophthalazine-1,4-diol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ambeed | A375978 | 6-Bromophthalazine-1,4-diol 95% | 76240-49-8 | 100mg | $15 | 2026-06-05 | Buy |
| Ambeed | A375978 | 6-Bromophthalazine-1,4-diol 95% | 76240-49-8 | 250mg | $23 | 2026-06-05 | Buy |
| Ambeed | A375978 | 6-Bromophthalazine-1,4-diol 95% | 76240-49-8 | 1g | $34 | 2026-06-05 | Buy |
| Ambeed | A375978 | 6-Bromophthalazine-1,4-diol 95% | 76240-49-8 | 5g | $138 | 2026-06-05 | Buy |
| Ambeed | A375978 | 6-Bromophthalazine-1,4-diol 95% | 76240-49-8 | 10g | $275 | 2026-06-05 | Buy |
6-broMophthalazine-1,4-diol Chemical Properties,Uses,Production
Synthesis
86-90-8
76240-49-8
The general procedure for the synthesis of 6-bromophthalazine-1,4-diol from 5-bromoisobenzofuran-1,3-dione was as follows: 4-bromophthalic anhydride (50 g, 0.22 mol) was dissolved in acetic acid (150 mL) with stirring and heated for 1 hour at 125 °C. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the slow dropwise addition of hydrazine hydrate (11.25 mL, 0.23 mol) over a period of 5 min, at which time the formation of a thick white solid was observed. The addition of acetic acid (50 mL) was continued and the mixture was heated again at 125 °C for 30 min. The reaction mixture was cooled, diluted with acetic acid (200 mL) and filtered. The filter cake was washed with acetic acid (3 x 100 mL) and subsequently dried under vacuum. The dried solid was dissolved in 5% (w/w) NaOH solution (250 mL) and the suspension was acidified with acetic acid (30 mL) to produce a thick white precipitate. The mixture was filtered and the filter cake was washed sequentially with water (2 × 200 mL) and methanol (2 × 200 mL), and finally dried under vacuum at 40 °C to afford 6-bromo-2,3-dihydrophthalazine-1,4-dione as a white solid (55 g, 0.23 mol, quantitative yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ= 8.16 (dd, J = 0.7,2.0 Hz, 1H), 7.98 (dd, J = 0.7,8.4 Hz, 1H), 7.93 (d, J = 8.4 Hz, 1H), 1.84 (s, 2H).
References
[1] Patent: WO2016/92326, 2016, A1. Location in patent: Paragraph 00326
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 10, p. 1684 - 1687
[3] Patent: WO2008/61108, 2008, A2. Location in patent: Page/Page column 65-66
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1834 - 1840
[5] Patent: WO2004/99177, 2004, A1. Location in patent: Page 19-20
6-broMophthalazine-1,4-diol Preparation Products And Raw materials
6-broMophthalazine-1,4-diol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 qq272369594;2159423853qq | 2723695949@qq.com | China | 4991 | 50 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Suzhou JingTong Pharmaceutical Co., Ltd. | 13675155016 | tongtf110@sina.com | China | 963 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
