8,11,14-Eicosatriynoic Acid
- CAS No.
- 34262-64-1
- Chemical Name:
- 8,11,14-Eicosatriynoic Acid
- Synonyms
- QLLIWTBTVOPGCM-UHFFFAOYSA-N;8,11,14-Eicosatriynoic Acid
- CBNumber:
- CB92590090
- Molecular Formula:
- C20H28O2
- Molecular Weight:
- 300.44
- MDL Number:
- MFCD00156106
- MOL File:
- 34262-64-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
8,11,14-Eicosatriynoic Acid price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10007900 | 8,11,14-Eicosatriynoic Acid ≥98% | 34262-64-1 | 1mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 10007900 | 8,11,14-Eicosatriynoic Acid ≥98% | 34262-64-1 | 5mg | $466 | 2026-04-30 | Buy |
| ChemScene | CS-0133885 | 8,11,14-Eicosatriynoic acid ≥98% | 34262-64-1 | 5mg | $1077 | 2026-06-04 | Buy |
| ApexBio Technology | C4940 | 8,11,14-Eicosatriynoic Acid | 34262-64-1 | 1mg | $170 | 2026-05-06 | Buy |
| ApexBio Technology | C4940 | 8,11,14-Eicosatriynoic Acid | 34262-64-1 | 5mg | $580 | 2026-05-06 | Buy |
8,11,14-Eicosatriynoic Acid Chemical Properties, Uses, Production
Uses
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization[1][2][3]. 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Definition
ChEBI: 8,11,14,18-Eicosatetraynoic acid is a long-chain fatty acid.
Biological Activity
8,11,14-eicosatriynoic acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12-lipoxygenase (12-lo), cyclooxygenase (cox), and 5-lipoxygenase (5-lo) with ic50 values of 0.46 μm, 14 μm, and 25 μm, respectively. also, it inhibits the actions of slow-reacting substance of anaphylaxis with an ic50 value of 10 μm [1,2].lipoxygenases are found widely in fungi, plants, and animals in high levels. 12-lo is involved in a number of significant disease states and may play a role in oxidative glutamate toxicity. cox enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. cox enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them important clinically [3]. 5-lo is involved in cancer pathobiology. it is expressed by a variety of cancer cells including colon, lung, breast, and prostate and promotes cancer cell growth and neo-angiogenesis.
References
[1]. goetz, j., sprecher, h., cornwell, d., & panganamala, r. inhibition of prostaglandin biosynthesis by triynoic acids. prostaglandins. 1976; 12(2): 187-192.
[2]. sun, f., mcguire, j., morton, d., pike, j., sprecher, h., & kunau, w. inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. prostaglandins. 1981; 21(2): 333-343.
[3]. fitzpatrick, f. cyclooxygenase enzymes: regulation and function. current pharmaceutical design. 2004; 10(6): 577-588.
8,11,14-Eicosatriynoic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
8,11,14-Eicosatriynoic Acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9383 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 18019219489 18901678489 | tech@zzbioco.com | China | 12062 | 58 |
