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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one structure

CAS No.: 881386-01-2

Chemical Name:: 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Synonyms: Apixaban Impurity 65;Apixaban Impurity 60;RRSYY(Fasoracetam)-4;3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one;3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone;3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-;2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2;3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl);3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

CBNumber:: CB92594346

Molecular Formula:: C11H10Cl2N2O3

Molecular Weight:: 289.11

MDL Number:: MFCD23142941

MOL File:: 881386-01-2.mol

Last updated:2025-03-18 18:20:25

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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Properties

Boiling point	520.2±50.0 °C(Predicted)
Density	1.50
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly, Sonicated)
pka	-7.38±0.40(Predicted)
form	Solid
color	Light Yellow to Yellow
InChI	InChI=1S/C11H10Cl2N2O3/c12-11(13)6-1-7-14(10(11)16)8-2-4-9(5-3-8)15(17)18/h2-5H,1,6-7H2
InChIKey	KKVYXBZVPRSWHE-UHFFFAOYSA-N
SMILES	N1(C2=CC=C([N+]([O-])=O)C=C2)CCCC(Cl)(Cl)C1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-M2357	3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 99.73%	881386-01-2	10g	$50	2021-12-16	Buy
Ambeed	A985233	3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 97%	881386-01-2	25g	$67	2021-12-16	Buy
aablocks	AA00GTWP	3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 98%	881386-01-2	10g	$87	2021-12-16	Buy
Crysdot	CD11035802	3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 97%	881386-01-2	5g	$90	2021-12-16	Buy
aablocks	AA00GTWP	3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 98%	881386-01-2	25g	$127	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-M2357	10g	$50	Buy
A985233	25g	$67	Buy
AA00GTWP	10g	$87	Buy
CD11035802	5g	$90	Buy
AA00GTWP	25g	$127	Buy

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties,Uses,Production

Physical Form

Light Yellow to Yellow Solid

Description

3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.

Uses

3,??3-??Dichloro-??1-??(4-??nitrophenyl)??piperidin-??2-??one is a reagent used in the preparation of novel tetrahydropyrazolopyridone derivatives. Used in the preparation of anti-coagulants.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one synthesis

Synthesis of 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one from 1-(4-Nitrophenyl)-2-piperidinone

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Preparation Products And Raw materials

Raw materials

5-Chlorovaleryl chloride 1-(4-Nitrophenyl)-2-piperidinone

Preparation Products

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Suppliers

Global( 138)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Jinan Chenghui-Shuangda Chemical Co.,Ltd	+86-531-58897082	ericqiao@jnchsd.com	CHINA	158	58
Jinan Jianfeng Chemical Co., Ltd	+86-0531-88110457 +86-15562555968	info@pharmachemm.com	China	312	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Synbest Biotech(Hangzhou) Co., Ltd	86-571-88737065	sales@synbestech.com	CHINA	170	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29800	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5744	58
Wuhan Boye Science And Technology Development Co., Ltd.	27-81625225 +8615387090420	sumihu@boyechemicals.com	CHINA	215	58

Supplier	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Jinan Chenghui-Shuangda Chemical Co.,Ltd	58
Jinan Jianfeng Chemical Co., Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Standardpharm Co. Ltd.	58
Synbest Biotech(Hangzhou) Co., Ltd	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Wuhan Boye Science And Technology Development Co., Ltd.	58

View Lastest Price from 3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-05	3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 881386-01-2	US $0.00-0.00 / kg	1kg	0.99	800kg	Wuhan Biocar Pharmacy CO.,Ltd.
2025-09-30	2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- 881386-01-2	US $20.00 / KG	1KG	98%	20 tons	Speranza Chemical Co., Ltd.
2025-04-04	3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one 881386-01-2	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone
881386-01-2
US $0.00-0.00 / kg
0.99
Wuhan Biocar Pharmacy CO.,Ltd.

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-
881386-01-2
US $20.00 / KG
98%
Speranza Chemical Co., Ltd.

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
881386-01-2
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

881386-01-2(3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one)Related Search:

Apixaban Impurity 16 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity 5 (BMS-591329-01) Apixaban IMpurity(BMS-778960-01)

ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide

Apixaban Apixaban IMpurity( Apixaban IMpurity 6 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide

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3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)- Apixaban Impurity 60 Apixaban Impurity 65 3,3-dichloro-1-(4-nitrophenyl)2-2-piperidinone 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2 RRSYY(Fasoracetam)-4 3,3-Dichloro-1-(4-Nitrophenyl)piperidin-2-one2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl) 881386-01-2