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ChemicalBook >> CAS DataBase List >>2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Structure
2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine structure
CAS No.
90213-67-5
Chemical Name:
2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
Synonyms
2,4-dichloro-7-methylpyrrolo[2,3-d]pyrimidine;2,4-Dichlor-7-methyl-7H-pyrrolo[2,3-d]pyrimidin;2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-7-methyl-
CBNumber:
CB92599442
Molecular Formula:
C7H5Cl2N3
Molecular Weight:
202.04
MDL Number:
MFCD13189421
MOL File:
90213-67-5.mol
MSDS File:
SDS
Last updated:2026-05-28 06:02:06
Request For Quotation

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance Off-white to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H303-H320
Precautionary statements  P312-P264-P305+P351+P338-P337+P313

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 119557 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 90213-67-5 1.00g $324 2026-05-18 Buy
Matrix Scientific 119557 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 90213-67-5 5.00g $1008 2026-05-18 Buy
Synthonix D13875 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 95+% 90213-67-5 1g $24 2026-05-06 Buy
Synthonix D13875 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 95+% 90213-67-5 5g $50 2026-05-06 Buy
Synthonix D13875 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 95+% 90213-67-5 10g $90 2026-05-06 Buy
Product number Packaging Price Buy
119557 1.00g $324 Buy
119557 5.00g $1008 Buy
D13875 1g $24 Buy
D13875 5g $50 Buy
D13875 10g $90 Buy

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Chemical Properties, Uses, Production

Synthesis

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE

90213-66-4

Iodomethane

74-88-4

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

90213-67-5

To a suspension of sodium hydride (480 mg, 12.00 mmol, 1.10 eq., 60% dispersed in mineral oil) in tetrahydrofuran (50 mL) was slowly added dropwise a solution of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (2 g, 10.64 mmol, 1.00 eq.) in tetrahydrofuran (50 mL). The reaction mixture was stirred at 0 °C for 30 min and then iodomethane (1.66 g, 11.70 mmol, 1.10 eq.) was added dropwise at the same temperature. After addition, the reaction system was brought to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water (20 mL) to the mixture and subsequently extracted with ethyl acetate. The combined organic phases were washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:5, v/v) as eluent to afford 2.1 g (98% yield) of the title compound, 2,4-dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, as a white solid.LC-MS (ESI, m/z): 202 [M+H]+.

References

[1] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0436; 0437; 0588; 0589
[2] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 118
[3] Patent: WO2017/59191, 2017, A1. Location in patent: Paragraph 00235-00239
[4] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 51
[5] Patent: CN107226808, 2017, A. Location in patent: Paragraph 0366-0369

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine synthesis

90213-66-4
74-88-4
90213-67-5
Synthesis of 2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine from 2,4-Dichloro-7H-pyrrolo2,3-dpyrimidine and Iodomethane

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Preparation Products And Raw materials

Raw materials

2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol 2,4-Dichloro-7H-pyrrolo2,3-dpyrimidine Ethyl 2,2-diethoxyethylcyanoacetate Sodium hydride
Iodomethane Tetrahydrofuran Acetonitrile

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Preparation Products

5-BroMo-2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Suppliers

Global Suppliers ( 52)
Supplier Tel Email Country ProdList Advantage
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
Shanghai Hong-chuang Pharma Tech Co., Ltd. 18151128828 hc-sales@foxmail.com China 2635 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3698 58
Changzhou Hopschain Chemical Co.,Ltd. 85528066 13775048983 sales@hopschem.com China 31548 55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Pure Chemistry Scientific Inc. 62
Shanghai Topbiochem Technology Co., Ltd 58
CEG Chemical Science&Technology Co., Ltd. 58
Shanghai Hong-chuang Pharma Tech Co., Ltd. 55
Bide Pharmatech Ltd. 60
Shanghai Worldyang Chemical Co.,Ltd. 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
Changzhou Hopschain Chemical Co.,Ltd. 55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Amadis Chemical Company Limited 58

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine Spectrum

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(90213-67-5)1HNMR

90213-67-5 (2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine) Related Search:

2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 2,4-dichloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine 2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 2,4,6-Trichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
2,4-Dichloro-7-ethyl-7H-pyrrolo[2,3-d]pyrimidine

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2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine 2,4-Dichlor-7-methyl-7H-pyrrolo[2,3-d]pyrimidin 7H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-7-methyl- 2,4-dichloro-7-methylpyrrolo[2,3-d]pyrimidine 90213-67-5 Heterocycle-Pyrimidine series pyrimidine