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2,3,4-Trimethoxybenzaldehyde

2,3,4-Trimethoxybenzaldehyde Structure
2,3,4-Trimethoxybenzaldehyde structure
CAS No.
2103-57-3
Chemical Name:
2,3,4-Trimethoxybenzaldehyde
Synonyms
TriMetazidine EP IMpurity-C;Benzaldehyde, 2,3,4-trimethoxy-;2,3,4-TMB;AKOS BBS-00003174;2,3,4-TrimethoxybenzaL;Trimetazidine Impurity C;4-TriMethoxybenzaldehyde;trimetazidine impurity1139;2,3,4-Trimetoxybenzaldehyde;Trimetazidine intermediate
CBNumber:
CB9260504
Molecular Formula:
C10H12O4
Molecular Weight:
196.2
MDL Number:
MFCD00003310
MOL File:
2103-57-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:22:35
Product description Number Pack Size Price
2,3,4-Trimethoxybenzaldehyde 99% 152099 10g $36.5
2,3,4-Trimethoxybenzaldehyde 99% 152099 50g $119
2,3,4-Trimethoxybenzaldehyde >98.0%(GC) T1101 25g $63
2,3,4-Trimethoxybenzaldehyde ≥99%(GC) 26868 5G $18.53
2,3,4-Trimethoxybenzaldehyde ≥99%(GC) 26868 25G $32.95
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2,3,4-Trimethoxybenzaldehyde Properties

Melting point 38-40 °C(lit.)
Boiling point 168-170 °C12 mm Hg(lit.)
Density 1.2166 (rough estimate)
refractive index n20/D 1.5547(lit.)
Flash point >230 °F
storage temp. Inert atmosphere,2-8°C
solubility methanol: 0.1 g/mL, clear
form Crystals or Crystalline Powder
color White to light yellow
Sensitive Air Sensitive
BRN 981091
InChI InChI=1S/C10H12O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-6H,1-3H3
InChIKey UCTUXUGXIFRVGX-UHFFFAOYSA-N
SMILES C(=O)C1=CC=C(OC)C(OC)=C1OC
CAS DataBase Reference 2103-57-3(CAS DataBase Reference)
FDA UNII 7ZY3UK34C4
NIST Chemistry Reference Benzaldehyde, 2,3,4-trimethoxy-(2103-57-3)
EPA Substance Registry System Benzaldehyde, 2,3,4-trimethoxy- (2103-57-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi,C
Risk Statements  36/37/38-34
Safety Statements  22-24/25-45-36/37/39-27-26
WGK Germany  3
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29124900
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
0 0

2,3,4-Trimethoxybenzaldehyde price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 152099 2,3,4-Trimethoxybenzaldehyde 99% 2103-57-3 10g $36.5 2026-04-30 Buy
Sigma-Aldrich 152099 2,3,4-Trimethoxybenzaldehyde 99% 2103-57-3 50g $119 2026-04-30 Buy
TCI Chemical T1101 2,3,4-Trimethoxybenzaldehyde >98.0%(GC) 2103-57-3 25g $63 2026-04-30 Buy
Chem-Impex 26868 2,3,4-Trimethoxybenzaldehyde ≥99%(GC) 2103-57-3 5G $18.53 2026-05-19 Buy
Chem-Impex 26868 2,3,4-Trimethoxybenzaldehyde ≥99%(GC) 2103-57-3 25G $32.95 2026-05-19 Buy
Product number Packaging Price Buy
152099 10g $36.5 Buy
152099 50g $119 Buy
T1101 25g $63 Buy
26868 5G $18.53 Buy
26868 25G $32.95 Buy

2,3,4-Trimethoxybenzaldehyde Chemical Properties,Uses,Production

Description

2,3,4-Trimethoxybenzaldehyde is a white crystalline powder, and the chemical formula is C 10H 12O 4; the molecular weight is 196.2; the fusing point is 38-40 degrees, and is a kind of important medicine intermediate; it is mainly used in new type drug Ca2+ Synthesizing of channel blocker. The alternative cerebral arteries that are used for this medicine reduce the headache incidence, mainly for the preparation of the intermediate of trimetazidine.

Synthesis

A coking gallic acid is utilized as a raw material, and dimethyl sulfate is utilized as an alkylate reagent; under the condition of the existence of sodium hydroxide, methylation is performed through an O-alkylation reaction to obtain an intermediate 1, 2, 3-trimethoxybenzene. After that, the 1,2, 3-trimethoxybenzene and a Vilsmeier-Haack reagent are subjected to a formylation reaction to get the 2,3,4-Trimethoxybenzaldehyde.

Chemical Properties

white to light yellow crystals or cryst. powder

Uses

2,3,4-Trimethoxybenzaldehyde is a trimethoxylated aromatic aldehyde. 2,3,4-Trimethoxybenzaldehyde is an Impurity of the anti-anginal drug Trimetazidine (T795610).

Uses

2,3,4-Trimethoxybenzaldehyde was used to study the effects of 2,3,4-trimethoxybenzaldehyde on tubulin-dependent GTP hydrolysis.

Purification Methods

The reference substance of 2,3,4-trimethoxybenzaldehyde was prepared from an industrial grade product of 2,3,4-trimethoxybenzaldehyde by NaHSO3 addition reaction followed by re-crystallization in ethanol.

References

[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 22, p. 3721 - 3734
[2] Molecules, 2015, vol. 20, # 5, p. 9229 - 9241
[3] Justus Liebigs Annalen der Chemie, 1972, vol. 763, p. 109 - 120

2,3,4-Trimethoxybenzaldehyde synthesis

50-00-0
634-36-6
2103-57-3
Synthesis of 2,3,4-Trimethoxybenzaldehyde from Formaldehyde and 1,2,3-Trimethoxybenzene

2,3,4-Trimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Gallic acid Benzenemethanamine, 2,3,4-trimethoxy-N,N-dimethyl- 2,3,4-TRIMETHOXYBENZYL ALCOHOL 2,3,4-Trihydroxybenzaldehyde 1,2,3-Trimethoxybenzene
Formaldehyde Phosphorus oxitrichloride [(difluoromethyl)thio]benzene Iodomethane Acetone

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Preparation Products

Trimethoprim Phenethyl alcohol 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3,4-TRIMETHOXYPHENYLACETIC ACID Trimetazidine
trans-2,3,4-Trimethoxycinnamic acid Lomerizine hydrochloride (2E)-1-(3-nitrophenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one 1-methyl-3,5-bis(2,3,4-trimethoxybenzylidene)-4-piperidinone 1,2,3,4-tetramethoxy-5-allylbenzene

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2,3,4-Trimethoxybenzaldehyde Suppliers

Global( 612)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Wisdom Chemicals Co., Ltd.
+8613701363759 market@wisdomchem.com China 254 58
Zhejiang Brunova Technology Co., Ltd.
8617857108485 17857108485 info@zjbrunova.com China 48 58
Nanjing Dorra Pharmaceutical Technology Co., Ltd
+86-15951889564 +86-025-82232955 info@dorrapharma.com China 29 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5233 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Supplier Advantage
Beijing Wisdom Chemicals Co., Ltd.
58
Zhejiang Brunova Technology Co., Ltd.
58
Nanjing Dorra Pharmaceutical Technology Co., Ltd
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

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View Lastest Price from 2,3,4-Trimethoxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3,4-Trimethoxybenzaldehyde pictures 2026-05-26 2,3,4-Trimethoxybenzaldehyde
2103-57-3
 0.99 RongNa Biotechnology Co.,Ltd
2,3,4-Trimethoxybenzaldehyde pictures 2026-05-21 2,3,4-Trimethoxybenzaldehyde
2103-57-3
 US $12.00 / kg 1kg 99% 200mt Jinan Finer Chemical Co., Ltd
2,3,4-Trimethoxybenzaldehyde pictures 2026-05-05 2,3,4-Trimethoxybenzaldehyde
2103-57-3
 US $80.00-800.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd

2,3,4-Trimethoxybenzaldehyde Spectrum

2,3,4-Trimethoxybenzaldehyde(2103-57-3)MS2,3,4-Trimethoxybenzaldehyde(2103-57-3)1HNMR2,3,4-Trimethoxybenzaldehyde(2103-57-3)13CNMR2,3,4-Trimethoxybenzaldehyde(2103-57-3)IR12,3,4-Trimethoxybenzaldehyde(2103-57-3)IR22,3,4-Trimethoxybenzaldehyde(2103-57-3)Raman

2103-57-3(2,3,4-Trimethoxybenzaldehyde)Related Search:

p-Anisaldehyde 4-(Trifluoromethoxy)aniline Trimethyl phosphite Mesitaldehyde 3-(Trifluoromethyl)benzaldehyde
3-Methoxybenzaldehyde 3-(Trifluoromethoxy)bromobenzene o-Anisaldehyde (Trifluoromethoxy)benzene 2,3,4-Trihydroxybenzaldehyde
2,3,4-TRIMETHOXYPHENYLACETIC ACID TriMethopriM IMpurity C 3-Iodobenzyl bromide 3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers) Trimethoprim Related Compound B (25 mg) (2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl)methanone) (AS)
1,4-Bis(2,3,4-triMethoxybenzyl)piperazine 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester 1-(3,4,5-TRIMETHOXY-BENZYL)-PIPERAZINE

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2,3,4-trimethoxy-benzaldehyd 2,3,4-TRIMETHOXYBENZALDEHYDE FOR SYNTHES TriMetazidine EP IMpurity-C Trimetazidine Impurity C 2,3,4-TriMethoxybenzaldehyde, 97+% 2,3,4-TrimethoxybenzaL 2,3,4-Trimedhoxy Benzaldehyde Trimetazidine Impurity 3（Trimetazidine EP Impurity C) 2,3,4-Trimethoxybenzaidehyde 2,3,4 TRIMETHOXYBENZYLALDEHYDE 2,3,4-TRIMETHOXYBENZALDEHYDE 2,3,4-TMB 2,3,4-Trimethoxybenzaldehyde, 99+% Benzaldehyde, 2,3,4-trimethoxy- 2,3,4-trimethoxybenzaldehyde (intermediate of trimetazidine.) 2,3,4-Trimetoxybenzaldehyde 4.2,3,4-trimethoxybenzaldehyde 2,3,4-TRIMETHOXYBENZALDEHYDE, 98+% 4-TriMethoxybenzaldehyde 2,3,4-TriMethoxybenzaldehyde, 99% 10GR AKOS BBS-00003174 2,3,4-Trimethoxybenzaldehyde ISO 9001：2015 REACH trimetazidine impurity1139 2,3,4-Trimethoxybenzaldehyde (Trimetazidine Hydrochloride Impurity) Trimetazidine Dihydrochloride Impurity C Trimetazidine Dihydrochloride EP Impurity C Trimetazidine intermediate 2103-57-3 2103-57-31 Organic Building Blocks ALDEHYDE Aldehydes Building Blocks C10 to C21 Carbonyl Compounds Aromatics, Impurities, Intermediates BUILDING BLOCKS Benzaldehyde API intermediates (intermediate of trimetazidine.) Aldehydes C10 to C21 Carbonyl Compounds Aromatic Aldehydes & Derivatives (substituted) bc0001 2103-57-3