1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid
- CAS No.
- 872422-15-6
- Chemical Name:
- 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid
- Synonyms
- 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid;1-(4-bromo-2-fluorophenyl)-сyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-(4-bromo-2-fluorophenyl)-;1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carboxylic acid
- CBNumber:
- CB92641006
- Molecular Formula:
- C10H8BrFO2
- Molecular Weight:
- 259.07
- MDL Number:
- MFCD12405622
- MOL File:
- 872422-15-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid | XJB42215 | 2.5g | $472 |
| 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | PC901560 | 250mg | $24 |
| 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | PC901560 | 1g | $92 |
| 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | PC901560 | 5g | $449 |
| 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | PC901560 | 25g | $2230 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2916200090 |
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XJB42215 | 1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid | 872422-15-6 | 2.5g | $472 | 2026-06-05 | Buy |
| Apolloscientific | PC901560 | 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | 872422-15-6 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC901560 | 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | 872422-15-6 | 1g | $92 | 2026-06-04 | Buy |
| Apolloscientific | PC901560 | 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | 872422-15-6 | 5g | $449 | 2026-06-04 | Buy |
| Apolloscientific | PC901560 | 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid 98% | 872422-15-6 | 25g | $2230 | 2026-06-04 | Buy |
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid Chemical Properties,Uses,Production
Synthesis
114897-91-5
107-04-0
872422-15-6
Step 1. Sodium hydroxide (50% aqueous solution, 5.71 mL, 0.149 mol) was added to a mixture of 4-bromo-2-fluorobenzyl cyanide (3.16 g, 0.0145 mol), benzyltriethylammonium chloride (0.26 g, 0.0011 mol), and 1-bromo-2-chloroethane (2.51 mL, 0.0302 mol), and the reaction was allowed to proceed at 50 °C for for 10 hours. After completion of the reaction, the mixture was poured into ice water (50 mL) and extracted with ether (2 x 50 mL). The organic phases were combined, washed with brine (30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2.88 g of brown solid. The formation of the nitrile intermediate was confirmed by 1H-NMR. Step 2. 50% aqueous sodium hydroxide solution (3.8 mL) and ethylene glycol (20 mL) were added to the residue obtained above, and the mixture was heated to 100 °C and stirred overnight. After the reaction was completed, the mixture was poured into water (50 mL) and washed with ether (2 x 50 mL). The aqueous layer was cooled with an ice bath and acidified slowly by adding 6N hydrochloric acid to pH=2. The product was extracted with ethyl acetate (2 x 100 mL), dried over anhydrous magnesium sulfate and concentrated to give 1.634 g (70% yield) of the target product 1-(4-bromo-2-fluorophenyl)cyclopropanecarboxylic acid. The structure of the product was confirmed by 1H NMR.
References
[1] Patent: US2005/288338, 2005, A1. Location in patent: Page/Page column 34
[2] Patent: WO2006/20598, 2006, A2. Location in patent: Example 145.1
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid Suppliers
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