2-Amino-5-fluorobenzoic acid methyl ester
- CAS No.
- 319-24-4
- Chemical Name:
- 2-Amino-5-fluorobenzoic acid methyl ester
- Synonyms
- Methyl-5-fluoroanthranilate;Methyl 2-amino-5-fluorobenzoat;METHYL 2-AMINO-5-FLUOROBENZOATE;4-Fluoro-2-(methoxycarbonyl)aniline;2-Amino-5-fluorbenzoesuremethylester;5-Fluoroanthranilic Acid Methyl Ester;2-AMINO-5-FLUORO BENZOIC ACID METHYL ESTER;2-AMINO-5-FLUOROBENZONIC ACID METHYL ESTER;Benzoic acid, 2-amino-5-fluoro-, methyl ester;4-Fluoro-2-(methoxycarbonyl)aniline, Methyl 5-fluoroanthranilate
- CBNumber:
- CB9264845
- Molecular Formula:
- C8H8FNO2
- Molecular Weight:
- 169.15
- MDL Number:
- MFCD03791308
- MOL File:
- 319-24-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 5-Fluoroanthranilate >98.0%(GC) | M2899 | 5g | $193 |
| Methyl 5-Fluoroanthranilate >98.0%(GC) | M2899 | 25g | $773 |
| Methyl2-amino-5-fluorobenzoate | M328700 | 10g | $100 |
| Methyl2-amino-5-fluorobenzoate | M328700 | 5g | $65 |
| Methyl2-amino-5-fluorobenzoate | J97204 | 25g | $70 |
| More product size | |||
| Melting point | 34-37°C |
|---|---|
| Boiling point | 100-102°C 0,5mm |
| Density | 1,26 g/cm3 |
| vapor pressure | 10-80Pa at 20-50℃ |
| Flash point | 132°C |
| storage temp. | 2-8°C(protect from light) |
| pka | 2.08±0.10(Predicted) |
| form | powder to lump |
| color | White to Yellow to Green |
| BRN | 2803210 |
| LogP | 2.4-2.47 at 20-25℃ |
| Surface tension | 53.1mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 319-24-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 52/53 | |||||||||
| Safety Statements | 22-24/25-61 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
2-Amino-5-fluorobenzoic acid methyl ester price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2899 | Methyl 5-Fluoroanthranilate >98.0%(GC) | 319-24-4 | 5g | $193 | 2026-03-19 | Buy |
| TCI Chemical | M2899 | Methyl 5-Fluoroanthranilate >98.0%(GC) | 319-24-4 | 25g | $773 | 2026-03-19 | Buy |
| TRC | M328700 | Methyl2-amino-5-fluorobenzoate | 319-24-4 | 10g | $100 | 2021-12-16 | Buy |
| TRC | M328700 | Methyl2-amino-5-fluorobenzoate | 319-24-4 | 5g | $65 | 2021-12-16 | Buy |
| AK Scientific | J97204 | Methyl2-amino-5-fluorobenzoate | 319-24-4 | 25g | $70 | 2021-12-16 | Buy |
2-Amino-5-fluorobenzoic acid methyl ester Chemical Properties,Uses,Production
Uses
2-Amino-5-fluorobenzoic acid methyl ester is used as an intermediate component in the preparation of hepatitis B virus (HBV) vaccines and quinazoline derivatives. It is also used in the synthesis of other organic heterocyclic compounds such as 2-aminobenzoates and α,β-unsaturated ketones.
Synthesis
67-56-1
446-08-2
319-24-4
General procedure for the synthesis of methyl 2-amino-5-fluorobenzoate from methanol and 2-amino-5-fluorobenzoic acid: 2-amino-5-fluorobenzoic acid (9.29 mmol, 1.440 g) was dissolved in 3N HCl/MeOH solution (30 mL), and heated to reflux at 100 °C overnight. Upon completion of the reaction, the solvent was removed by evaporation and the crude product was separated by extraction between dichloromethane (DCM) and saturated aqueous potassium carbonate (K2CO3). The organic phase was collected, evaporated and concentrated, and purified by silica gel (SiO2) column chromatography with hexane/ethyl acetate mixed solvent as eluent to give 0.650 g of methyl 2-amino-5-fluorobenzoate in 42% yield. The structure of the product was confirmed by 1H NMR (200 MHz, CDCl3): δ 3.9 (s, 3H), 5.6 (s, 2H), 6.6 (dd, J = 9.0, 4.7 Hz, 1H), 7.0 (m, 1H), 7.5 (dd, J = 9.8, 3.1 Hz, 1H). Mass spectrometry analysis (ESI/MS) showed the molecular ion peak m/z 170 [M+1]+.
References
[1] Patent: WO2009/21696, 2009, A1. Location in patent: Page/Page column 65-66
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 24, p. 5923 - 5936
[3] Chemistry of Heterocyclic Compounds, 2006, vol. 42, # 1, p. 64 - 69
[4] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 2, p. 415 - 420
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8332 - 8338
2-Amino-5-fluorobenzoic acid methyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from 2-Amino-5-fluorobenzoic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 2-Amino-5-fluorobenzoic acid methyl ester
319-24-4
|
US $0.00-0.00 / KG | 5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 2-Amino-5-fluorobenzoic acid methyl ester
319-24-4
|
US $1.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
-
- 2-Amino-5-fluorobenzoic acid methyl ester
319-24-4
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Amino-5-fluorobenzoic acid methyl ester
319-24-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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