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Magnolol

Magnolol Structure
Magnolol structure
CAS No.
528-43-8
Chemical Name:
Magnolol
Synonyms
5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol;Maglol;MAGNOLOL;NSC 293099;HONOKIOL(P);MAGNOLOL(P);Magnolol D6;Magnolol-RM;MAGNOLOL(SH);Magnolol CRS
CBNumber:
CB9265352
Molecular Formula:
C18H18O2
Molecular Weight:
266.33
MDL Number:
MFCD00016658
MOL File:
528-43-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:43:48
Product description Number Pack Size Price
Magnolol European Pharmacopoeia (EP) Reference Standard Y0001289 20 mg $241
Magnolol phyproof? Reference Substance PHL89317 20mg $395
Magnolol ≥95% (HPLC), from plant M3445 10mg $197
Magnolol European Pharmacopoeia (EP) Reference Standard Y0001289 y0001289 $220
5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC) D3971 1g $143
More product size
Request For Quotation

Magnolol Properties

Melting point 101.5-102°
Boiling point 180°C/1mmHg(lit.)
Density 1.107±0.06 g/cm3(Predicted)
FEMA 4559 | MAGNOLOL
storage temp. Sealed in dry,2-8°C
solubility ethanol: soluble1mg/mL
pka 9.49±0.43(Predicted)
form Solid
color White to Almost white
Odor bitter
biological source plant
λmax 292nm(EtOH)(lit.)
Merck 14,5697
JECFA Number 2023
Stability Light Sensitive
Major Application metabolomics
vitamins, nutraceuticals, and natural products
Cosmetics Ingredients Functions ANTIOXIDANT
BLEACHING
InChI 1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2
InChIKey VVOAZFWZEDHOOU-UHFFFAOYSA-N
SMILES Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O
LogP 4.502 (est)
CAS DataBase Reference 528-43-8(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) MAGNOLOL
EWG's Food Scores 1
FDA UNII 001E35HGVF
UNSPSC Code 41116107
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Environment (GHS09)
GHS05,GHS07,GHS09
Signal word  Danger
Hazard statements  H315-H318-H335-H411
Precautionary statements  P273-P280-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  N
Risk Statements  37/38-41-51/53
Safety Statements  26-39-61
RIDADR  UN 3077
WGK Germany  3
RTECS  DV5105500
HazardClass  9
HS Code  29072990
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 2
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
Hazardous Substances Data 528-43-8(Hazardous Substances Data)
Toxicity LD50 orl-mus: 2200 mg/kg BRXXAA #5135746
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
3 0

Magnolol price More Price(125)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001289 Magnolol European Pharmacopoeia (EP) Reference Standard 528-43-8 20 mg $241 2026-04-30 Buy
Sigma-Aldrich PHL89317 Magnolol phyproof? Reference Substance 528-43-8 20mg $395 2026-04-30 Buy
Sigma-Aldrich M3445 Magnolol ≥95% (HPLC), from plant 528-43-8 10mg $197 2026-04-30 Buy
Sigma-Aldrich Y0001289 Magnolol European Pharmacopoeia (EP) Reference Standard 528-43-8 y0001289 $220 2024-03-01 Buy
TCI Chemical D3971 5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC) 528-43-8 1g $143 2026-04-30 Buy
Product number Packaging Price Buy
Y0001289 20 mg $241 Buy
PHL89317 20mg $395 Buy
M3445 10mg $197 Buy
Y0001289 y0001289 $220 Buy
D3971 1g $143 Buy

Magnolol Chemical Properties,Uses,Production

Description

Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors.

References

https://en.wikipedia.org/wiki/Magnolol
https://www.caymanchem.com/product/14233

Description

Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).

Chemical Properties

White or off-white powder

Uses

Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.

Definition

ChEBI: Magnolol is a member of biphenyls.

Hazard

Moderately toxic by ingestion.

Biological Activity

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

Mechanism of action

Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.

in vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

in vivo

Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.

References

[1] VIKTOR REMPEL. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55[J]. ACS Medicinal Chemistry Letters, 2012, 4 1: 41-45. DOI: 10.1021/ml300235q

Magnolol synthesis

73429-23-9
528-43-8
Synthesis of Magnolol from 1,1'-Biphenyl, 2,2'-bis(2-propen-1-yloxy)-

Magnolol Preparation Products And Raw materials

Raw materials

2-Naphthalenemethanol, decahydro-8-[(2'-hydroxy-5,5'-di-2-propen-1-yl[1,1'-biphenyl]-2-yl)oxy]-α,α,4a,8-tetramethyl-, (2R,4aR,8R,8aR)-

Preparation Products

Magnolol Suppliers

Global( 594)Suppliers
Supplier Tel Email Country ProdList Advantage
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213306 +8618374838656 info@staherb.cn China 987 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5231 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
HR Biotechnology Co.,Ltd 		+8618565342020 sales@chemhy.com China 112 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 477 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Shaanxi Xianhe Biotech Co., Ltd 		+86-17709210191; +8617709210191 Jerry@xhobio.com China 906 58
Wuhan JiyunZen Tech Co., Ltd. 		+86-18062099985 Amyjiyunzen@yeah.net China 672 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Supplier Advantage
Changsha Staherb Natural Ingredients Co., Ltd.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
HR Biotechnology Co.,Ltd 		58
BINBO BIOLOGICAL CO.,LTD 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Shaanxi Xianhe Biotech Co., Ltd 		58
Wuhan JiyunZen Tech Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60

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View Lastest Price from Magnolol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
magnolol pictures 2026-05-29 magnolol
528-43-8
 US $0.00-0.00 / kg 1kg 1%-98% 1000 Changsha Staherb Natural Ingredients Co., Ltd.
magnolia bark extract magnolol pictures 2026-05-29 magnolia bark extract magnolol
528-43-8
 US $0.00-0.00 / kg 1kg 90%; 98% HPLC 1000kg Changsha Staherb Natural Ingredients Co., Ltd.
Magnolol pictures 2026-05-28 Magnolol
528-43-8
 US $0.00 / kg 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
  • magnolol pictures
  • magnolol
    528-43-8
  • US $0.00-0.00 / kg
  • 1%-98%
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Magnolol pictures
  • Magnolol
    528-43-8
  • US $0.00 / kg
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd

Magnolol Spectrum

Magnolol(528-43-8)1HNMR

528-43-8(Magnolol)Related Search:

Allyl chloride Diallylamine Diallyldisulfide Allyl bromide Sodium allylsulfonate
Allyl glycidyl ether MAGNOLIABARKEXTRACT Allylamine 2,2'-Biphenol 2-Phenylphenol
3,3'-Dimethylbiphenyl CUPRESSUFLAVONE TRIHYDRATE Honokiol Magnolia bark Extract Honokiol Magnolol 3-(3-Methylphenyl)prop-1-ene
3-ETHYLBIPHENYL Magnolol Bornul magnolol

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5,5'-DIALLYL-BIPHENYL-2,2'-DIOL 5,5'-DIALLYL-2,2'-BIPHENYLDIOL 5,5'-DIALLYL-2,2'-DIHYDROXYBIPHENYL HONOKIOL(P) MAGNOLOL(SH) 5',5-di-2-propenyl-(1,1'-Biphenyl)-2,2'-diol MAGNOLOL Magnolia officinalis Rehd.et Wils MAGNOLOL 98.0% BY HPLC Honokiol std. Magnolol std. 1’-Biphenyl)-2,2’-diol,5’,5-di-2-propenyl-(1 MagnoliaofficinalisRehderetWilson Nano Liposomal Magnolol Magnolol, 98%, from Magnolia officinalis Rehder & E. H. Wilson Magnolol 528-43-8 Magnolol, ≥98%(HPLC) MAGNOLIABARKEXTRACT [1,1'-Biphenyl]-2,2'-diol,5,5'-di-2-propenyl- 2,2'-Bichavicol 2,2'-Biphenyldiol, 5,5'-diallyl- MAGNOLOL(P) Maglol Magnolol(2,2 -Bichavicol) 4,4'-Diallyl-2,2'-biphenol Magnolol, froM Houpoea officinalis [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl- NSC 293099 4-diphenylphosphoryl-N,N-dimethyl-4,4-diphenyl-1-butanamine Magnolol 2%-98% Magnolol CRS 5,5'-Diallyl-2,2'-dihydroxybiphenyl> Magnolol USP/EP/BP Magnolol D10 Magnolol D6 magnolia bark extract magnolol Magnolol Powder Magnolol (2,2'-Bichavicol) Magnolol-RM Magnolol, 10 mM in DMSO 2′-biphenyldiol Magnolia officinalis total phenols Totalis Phenoli Magnoliae Officinalis MAGNOLOL(REQUEST QUOTE) Magnolol (Standard) 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol 528-43-8 5291-75-5 Herb extract Plant extract Nutritional Ingredients chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Inhibitors Honokiol