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1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea structure

CAS No.: 1011301-27-1

Chemical Name:: 1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea

Synonyms: CS-1154;Tenovin-3;Tenovin-3, >=98%;Tenovin-3 ，S2176;TENOVIN 3;TENOVIN3;Tenovin-3, 10 mM in DMSO;Tenovin 3,MDM-2/p53,Inhibitor,Tenovin-3,inhibit;N-(4-aMinophenylcarbaMothioyl)-4-tert-butylbenzaMide;1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea;N-[[(4-Aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

CBNumber:: CB92654095

Molecular Formula:: C18H21N3OS

Molecular Weight:: 327.44

MDL Number:: MFCD25976437

MOL File:: 1011301-27-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-03 11:24:09

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1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Properties

storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥14.45 mg/mL in DMSO; ≥2.88 mg/mL in EtOH with gentle warming
form	solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16288	Tenovin-3 ≥98%	1011301-27-1	500μg	$107	2026-04-30	Buy
Cayman Chemical	16288	Tenovin-3 ≥98%	1011301-27-1	1mg	$203	2026-04-30	Buy
Cayman Chemical	16288	Tenovin-3 ≥98%	1011301-27-1	5mg	$583	2026-04-30	Buy
Cayman Chemical	16288	Tenovin-3 ≥98%	1011301-27-1	10mg	$1034	2026-04-30	Buy
Biosynth	LQB30127	Tenovin-3	1011301-27-1	0.5g	$472	2026-06-04	Buy

Product number	Packaging	Price	Buy
16288	500μg	$107	Buy
16288	1mg	$203	Buy
16288	5mg	$583	Buy
16288	10mg	$1034	Buy
LQB30127	0.5g	$472	Buy

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Chemical Properties, Uses, Production

Biological Activity

tenovin sar studies aimed at increasing water solubility

Synthesis

540-72-7

106-50-3

1710-98-1

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea

1011301-27-1

Under argon protection, 4-tert-butylbenzoyl chloride (10 mmol, 1.97 g) was dissolved in acetone (20 mL), sodium thiocyanate (10 mmol, 0.81 g) was added, and the reaction was stirred for 2 hours. Subsequently, the above reaction mixture was slowly added dropwise to a solution of 1,4-phenylenediamine (20 mmol, 2.16 g) in acetone (50 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 36 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue obtained was dissolved in dichloromethane, filtered to remove insoluble material and the filtrate was concentrated again. Purification was carried out by silica gel column chromatography, eluting using a solvent mixture of ethyl acetate-petroleum ether. The target fraction was collected, concentrated and ground with ether to afford analytically pure N-((4-aminophenyl)thiocarbamoyl)-4-(tert-butyl)benzamide in a yield of 2.45 g (75% yield). The product characterization data were as follows: melting point 189-191°C; 1H-NMR (CDCl3) δ 1.36 (s, 9H), 6.81 (m, 2H), 7.47 (m, 2H), 7.54 (m, 2H), 7.81 (m, 2H), 9.05 (s, 1H), 12.41 (s, 1H); MS (ES+) m/z 350 [M + Na]+; elemental analysis calculated value C18H21N3ONaS 350.1300, measured value 350.1303.

References

[1] Patent: WO2008/29096, 2008, A2. Location in patent: Page/Page column 22-23; 34-35
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1779 - 1793

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Preparation Products And Raw materials

Raw materials

Sodium thiocyanate p-Phenylenediamine 4-tert-Butylbenzoyl chloride

Preparation Products

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Suppliers

Global Suppliers ( 93)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
CEG Chemical Science&Technology Co., Ltd.	Mobile:13665161512		China	1784	58
Nanjing Chalf-Pharm Technology Co., Ltd.	025-57018978 18251899859	sales@chalf-pharm.com	China	5855	50
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Credit Asia Chemical Co., Ltd.	+86 (21) 61124340		China	9739	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
Shanghai Topbiochem Technology Co., Ltd	58
MedChemexpress LLC	58
Guangzhou Isun Pharmaceutical Co., Ltd	55
CEG Chemical Science&Technology Co., Ltd.	58
Nanjing Chalf-Pharm Technology Co., Ltd.	50
AdooQ Bioscience CHINA	60
Shanghai JiYi Biotechnology Co. Ltd.	55
Credit Asia Chemical Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55

View Latest Price from 1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-06-02	Tenovin-3 1011301-27-1	$55.00-213.00		99.72%	10g	TargetMol Chemicals Inc.
	2019-09-04	1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea 1011301-27-1	$5.00	1KG	99%	1ton	Career Henan Chemical Co

Tenovin-3
1011301-27-1
$55.00-213.00
99.72%
TargetMol Chemicals Inc.

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea
1011301-27-1
$5.00
99%
Career Henan Chemical Co

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Spectrum

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea(1011301-27-1)¹HNMR

1011301-27-1 (1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea) Related Search:

TENOVIN-1 Tenovin-6 Tenovin-2 N-(((4-((Isopropyl)phenylamino)phenyl)amino)thioxomethyl)benzamide 6-methyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

Tenovin 6 (Hydrochloride)

1of2

1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea N-(4-aMinophenylcarbaMothioyl)-4-tert-butylbenzaMide Tenovin-3 TENOVIN-3 1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea Tenovin-3, >=98% N-[[(4-Aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide TENOVIN 3;TENOVIN3 CS-1154 Benzamide, N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)- Tenovin 3,MDM-2/p53,Inhibitor,Tenovin-3,inhibit Tenovin-3, 10 mM in DMSO Tenovin-3 ，S2176 1011301-27-1 Inhibitors