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LEE011 (succinate)

LEE011 (succinate) Structure
LEE011 (succinate) structure
CAS No.
1374639-75-4
Chemical Name:
LEE011 (succinate)
Synonyms
Ribociclib succinate;RIBOCICLIB SUCCINATE (LEE011);Ribociclib Succinate (Kisqali);7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate;Ribociclib succite;LEE011 (succinate);1374639-75-4 LEE011 (succinate);Ribociclib succinate, 10 mM in DMSO;RIBOCICLIB SUCCINATE (LEE011 SUCCINATE);LEE-011 succinate salt, Ribociclib succinate salt
CBNumber:
CB92682010
Molecular Formula:
C27H36N8O5
Molecular Weight:
552.64
MDL Number:
MOL File:
1374639-75-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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LEE011 (succinate) Properties

Melting point >160oC (dec.)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Pale Beige
InChIKey NHANOMFABJQAAH-UHFFFAOYSA-N
SMILES C(C(=O)O)CC(=O)O.C(C1=CC2=CN=C(NC3N=CC(N4CCNCC4)=CC=3)N=C2N1C1CCCC1)(=O)N(C)C
NCI Dictionary of Cancer Terms ribociclib succinate
FDA UNII BG7HLX2919

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)Environment (GHS09)
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301-H315-H319-H372-H400
Precautionary statements  P273-P301+P310-P305+P351+P338-P314

LEE011 (succinate) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 36414 LEE011 (succinate) ≥98% 1374639-75-4 10mg $44 2026-04-30 Buy
Cayman Chemical 36414 LEE011 (succinate) ≥98% 1374639-75-4 25mg $77 2026-04-30 Buy
Cayman Chemical 36414 LEE011 (succinate) ≥98% 1374639-75-4 50mg $110 2026-04-30 Buy
Cayman Chemical 36414 LEE011 (succinate) ≥98% 1374639-75-4 100mg $154 2026-04-30 Buy
TRC TRC-L321000-5MG LEE011 Succinate >95%(HPLC) 1374639-75-4 5mg $72 2026-06-03 Buy
Product number Packaging Price Buy
36414 10mg $44 Buy
36414 25mg $77 Buy
36414 50mg $110 Buy
36414 100mg $154 Buy
TRC-L321000-5MG 5mg $72 Buy

LEE011 (succinate) Chemical Properties, Uses, Production

Uses

LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.

in vivo

CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (LEE011; 200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment[2].

IC 50

CDK4: 10 nM (IC50); CDK6: 39 nM (IC50)

LEE011 (succinate) Preparation Products And Raw materials

Raw materials

Preparation Products

LEE011 (succinate) Suppliers

Global Suppliers ( 190)
Supplier Tel Email Country ProdList Advantage
Shanghai Yu Ben Biotechnology Co., Ltd. 021-61350663 15502154572 1639466865@qq.com China 498 58
Shanghai YiWen Pharmaceutical Co., Ltd. 13621628489 1322392736@qq.com China 263 58
Shenzhen Yaoyuan R&D Center Co., Ltd 23284190 13421666688 664261110@qq.com China 88 58
Porton Pharma Solutions Ltd. 15169181595 ming.zhang3@portonpharma.com China 88 58
Hangzhou Kehui Pharmaceutical Co.,Ltd 0571-87359773 18094707759 sales10@hzkehuipharma.com China 68 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 022-60189726 18812034280 188120342808@163.com China 143 61
Synches Co., Ltd. 021-53292253 biz@synches.com China 199 64
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. 022-60116533 13207668525 saleskc@scipharmacn.com China 360 58
Suzhou Carbonwell Pharma-Tech Co., Ltd 0512-0512-88981216 13776013740 1320558046@qq.com China 72 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Supplier Advantage
Shanghai Yu Ben Biotechnology Co., Ltd. 58
Shanghai YiWen Pharmaceutical Co., Ltd. 58
Shenzhen Yaoyuan R&D Center Co., Ltd 58
Porton Pharma Solutions Ltd. 58
Hangzhou Kehui Pharmaceutical Co.,Ltd 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 61
Synches Co., Ltd. 64
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. 58
Suzhou Carbonwell Pharma-Tech Co., Ltd 58
Haoyuan Chemexpress Co., Ltd. 61

View Latest Price from LEE011 (succinate) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lee011 (succinate) pictures 2026-09-20 Lee011 (succinate)
1374639-75-4
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Ribociclib succinate pictures 2026-08-22 Ribociclib succinate
1374639-75-4
 $30.00-67.00 99.90% 10g TargetMol Chemicals Inc.
LEE011 (succinate) pictures 2026-06-30 LEE011 (succinate)
1374639-75-4
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

LEE011 (succinate) Spectrum

LEE011 (succinate)(1374639-75-4)1HNMR

1374639-75-4 (LEE011 (succinate)) Related Search:

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate LEE011 (hydrochloride) Ribociclib Neratinib Maleate 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester
2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

1of2

LEE011 (succinate) LEE-011 succinate salt, Ribociclib succinate salt RIBOCICLIB SUCCINATE (LEE011 SUCCINATE) Ribociclib succite RIBOCICLIB SUCCINATE (LEE011) 1374639-75-4 LEE011 (succinate) Ribociclib succinate, 10 mM in DMSO 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate Ribociclib succinate Ribociclib Succinate (Kisqali) 1374639-75-4 1286061-97-8 C23H30N8OC4H6O4 API