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diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Structure
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- structure
CAS No.
1246616-66-9
Chemical Name:
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
Synonyms
Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate;Dolutegravir DL4B;Dolutegravir Intermediate3;diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-;Dimethyl 4-oxo-3-benzyloxy-4H-pyran-2,5-dicarboxyl;imethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate;TIANFUCHEM diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-;2,5-Dimethyl 4-oxo-3-(phenylmethoxy)-4H-pyran-2,5-dicarboxylate;4-Oxo-3-benzyloxy-4H-pyran-2,5-dicarboxylic acid dimethyl ester;4-Oxo-3-(phenylMethoxy)-4H-pyran-2,5-dicarboxylic acid 2,5-diMethyl ester
CBNumber:
CB92685293
Molecular Formula:
C16H14O7
Molecular Weight:
318.28
MDL Number:
MFCD28128927
MOL File:
1246616-66-9.mol
MSDS File:
SDS
Last updated:2026-05-28 05:09:26
Request For Quotation

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Properties

Boiling point 534.9±50.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix D37211 Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 90+% 1246616-66-9 1g $22 2026-05-06 Buy
Synthonix D37211 Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 90+% 1246616-66-9 5g $50 2026-05-06 Buy
Synthonix D37211 Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 90+% 1246616-66-9 10g $120 2026-05-06 Buy
Synthonix D37211 Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 90+% 1246616-66-9 25g $160 2026-05-06 Buy
Synthonix D37211 Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 90+% 1246616-66-9 100g $460 2026-05-06 Buy
Product number Packaging Price Buy
D37211 1g $22 Buy
D37211 5g $50 Buy
D37211 10g $120 Buy
D37211 25g $160 Buy
D37211 100g $460 Buy

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Chemical Properties, Uses, Production

Uses

Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate is a useful intermediate for the preparation of dolutegravir and dolutegravir salts used in antiretroviral medications.

Synthesis

Dimethyl oxalate

553-90-2

Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-4-(phenylmethoxy)-, methyl ester

1246616-65-8

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-

1246616-66-9

To a reaction flask was added 30 mmol of methyl 4-benzyloxy-2-((dimethylamino)methylene)-3-acetoacetate (product of Example 2), 45 mmol of dimethyl oxalate, 15 mmol of sodium tert-butanol and 300 mL of toluene. The reaction flask was placed in an oil bath, heated to 105 °C and refluxed for 6 hours. After the reaction was completed, it was cooled to room temperature and filtered. The toluene solvent was removed by rotary evaporation to obtain the crude product. The crude product was purified by column chromatography with the eluent hexane:ethyl acetate=9:4 (v/v) to afford dimethyl 4-oxo-3-benzyloxy-4H-pyran-2,5-dicarboxylate in 90% yield.

References

[1] Patent: CN108101838, 2018, A. Location in patent: Paragraph 0038; 0039; 0040; 0041
[2] Patent: US2012/22251, 2012, A1. Location in patent: Page/Page column 24-25
[3] Patent: EP2602260, 2013, A1. Location in patent: Paragraph 0124

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Preparation Products And Raw materials

Raw materials

Dimethyl oxalate Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-4-(phenylmethoxy)-, methyl ester Toluene Sodium tert-butoxide

Preparation Products

(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide

diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Suppliers

Global Suppliers ( 125)
Supplier Tel Email Country ProdList Advantage
Shanghai Rochi Pharmaceutical Co., Ltd. 021-38751876 15000076078 Info@rochipharma.com China 616 55
Hangzhou Copiore Chemical Co., Ltd. 17300981287 13757145729 sales@copiore.com China 291 58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shenzhen HwaGen Pharmaceutical Co.,Ltd Q:3003761227 17722620669 liangcong.yi@rafflespt.com China 274 58
Taizhou Tongxin Bio-Tech Co., Ltd 0523-86818997 18652728585 sales@allyrise.com China 2993 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Shenzhen Nexconn Pharmatechs Ltd. 0755-89396905 admin@nexconn.com China 299 55
Nanjing Chalf-Pharm Technology Co., Ltd. 025-57018978 18251899859 sales@chalf-pharm.com China 5855 50
Supplier Advantage
Shanghai Rochi Pharmaceutical Co., Ltd. 55
Hangzhou Copiore Chemical Co., Ltd. 58
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Shanghai Hanhong Scientific Co.,Ltd. 64
Shenzhen HwaGen Pharmaceutical Co.,Ltd 58
Taizhou Tongxin Bio-Tech Co., Ltd 60
Bide Pharmatech Ltd. 60
Shanghai YuLue Chemical Co., Ltd. 55
Shenzhen Nexconn Pharmatechs Ltd. 55
Nanjing Chalf-Pharm Technology Co., Ltd. 50

View Latest Price from diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- pictures 2026-09-02 diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
1246616-66-9
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Oxo-3-(phenylmethoxy)-4h-pyran-2,5-dicarboxylic acid 2,5-dimethyl ester pictures 2025-04-04 4-Oxo-3-(phenylmethoxy)-4h-pyran-2,5-dicarboxylic acid 2,5-dimethyl ester
1246616-66-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- pictures 2019-07-06 diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
1246616-66-9
 $7.00 1kg 99% 100KG Career Henan Chemical Co

1246616-66-9 (diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-) Related Search:

GSK1349572 (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- 4-Oxo-3-(phenylMethoxy)-4H-pyran-2,5-dicarboxylic acid 2,5-diMethyl ester Dolutegravir Intermediate3 Dolutegravir DL4B 4H-Pyran-2,5-dicarboxylic acid, 4-oxo-3-(phenylmethoxy)-, 2,5-dimethyl ester TIANFUCHEM diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- imethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 4-Oxo-3-benzyloxy-4H-pyran-2,5-dicarboxylic acid dimethyl ester Dimethyl 4-oxo-3-benzyloxy-4H-pyran-2,5-dicarboxyl 2,5-Dimethyl 4-oxo-3-(phenylmethoxy)-4H-pyran-2,5-dicarboxylate Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 1246616-66-9 Dolutegravir INTERMEDIATES