VT-464 (raceMate)
- CAS No.
- 1375603-36-3
- Chemical Name:
- VT-464 (raceMate)
- Synonyms
- CS-1246;VT-464 (raceMate);Seviteronel racemate;1H-1,2,3-Triazole-5-methanol, α-[6,7-bis(difluoromethoxy)-2-naphthalenyl]-α-(1-methylethyl)-
- CBNumber:
- CB92715680
- Molecular Formula:
- C18H17F4N3O3
- Molecular Weight:
- 399.35
- MDL Number:
- MFCD28167780
- MOL File:
- 1375603-36-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
VT-464 (raceMate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3141 | Seviteronel racemate 98.11% | 1375603-36-3 | 5mg | $368 | 2026-06-04 | Buy |
| ChemScene | CS-3141 | Seviteronel racemate 98.11% | 1375603-36-3 | 10mg | $542 | 2026-06-04 | Buy |
| ChemScene | CS-3141 | Seviteronel racemate 98.11% | 1375603-36-3 | 25mg | $1007 | 2026-06-04 | Buy |
| ChemScene | CS-3141 | Seviteronel racemate 98.11% | 1375603-36-3 | 50mg | $1517 | 2026-06-04 | Buy |
| ChemScene | CS-3141 | Seviteronel racemate 98.11% | 1375603-36-3 | 100mg | $2058 | 2026-06-04 | Buy |
VT-464 (raceMate) Chemical Properties, Uses, Production
Uses
Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.
in vivo
The MDA-PCa-133 xenograft is derived from a clinical CRPC bone metastasis. Subcutaneous MDA-PCa-133 tumor expresses PSA, full-length androgen receptor (AR) and AR-V7 isoform. We determined the effect of Seviteronel (VT-464) and AA on MDA-PCa-133 growing in tumor-bearing castrated male mice: randomization into three groups; oral treatment with vehicle only, Seviteronel (VT-464), (100 mg/kg bid), or AA (100 mg/kg bid) for 25 days. Both Seviteronel (VT-464) and AA reduced tumor volume (>two fold compared to vehicle; p<0.05). These results indicate that selective Seviteronel (VT-464) CYP17 lyase inhibition is as effective as AA CYP17 inhibition in this model [2].
References
[1] Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. DOI:10.1016/j.bmcl.2014.04.024
[2] Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1
VT-464 (raceMate) Preparation Products And Raw materials
Raw materials
Preparation Products
VT-464 (raceMate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Lanzhou Angeli Biochemical Technology Co., Ltd. | 0931-8235634 13321316780 | 1455540579@qq.com | China | 957 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
View Latest Price from VT-464 (raceMate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Seviteronel racemate
1375603-36-3
|
$198.00-1140.00 | 10g | TargetMol Chemicals Inc. |
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- Seviteronel racemate
1375603-36-3
- $198.00-1140.00
- TargetMol Chemicals Inc.
