Methyl 4-chloro-6-Methoxypicolinate
- CAS No.
- 204378-37-0
- Chemical Name:
- Methyl 4-chloro-6-Methoxypicolinate
- Synonyms
- Regorafenib Impurity 125;Levocarnitine Impurity 49;Methyl 4-chloro-6-Methoxypicolinate;2-Pyridinecarboxylic acid, 4-chloro-6-methoxy-, methyl ester
- CBNumber:
- CB92732933
- Molecular Formula:
- C8H8ClNO3
- Molecular Weight:
- 201.61
- MDL Number:
- MFCD18257705
- MOL File:
- 204378-37-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
Methyl 4-chloro-6-Methoxypicolinate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 153540 | Methyl 4-chloro-6-methoxypicolinate | 204378-37-0 | 250.00mg | $65 | 2026-05-18 | Buy |
| Matrix Scientific | 153540 | Methyl 4-chloro-6-methoxypicolinate | 204378-37-0 | 1.00g | $248 | 2026-05-18 | Buy |
| Matrix Scientific | 153540 | Methyl 4-chloro-6-methoxypicolinate | 204378-37-0 | 5.00g | $1242 | 2026-05-18 | Buy |
| aablocks | AA0029CW | Methyl 4-chloro-6-Methoxypicolinate 95% | 204378-37-0 | 100mg | $38 | 2026-05-28 | Buy |
| aablocks | AA0029CW | Methyl 4-chloro-6-Methoxypicolinate 95% | 204378-37-0 | 250mg | $46 | 2026-05-28 | Buy |
Methyl 4-chloro-6-Methoxypicolinate Chemical Properties, Uses, Production
Synthesis
1443759-42-9
204378-37-0
General procedure for the synthesis of methyl 4-chloro-6-methoxypyridine-2-carboxylate from methyl 4-amino-6-methoxy-pyridine-2-carboxylate: to a mixture of 1.25 mL (10.5 mmol) of tert-butyl nitrite and 1.42 g (10.5 mmol) of copper(II) chloride in 40 mL of acetonitrile was added slowly, dropwise, at 40 °C, 1.20 g (6.59 mmol) of 4- methyl amino-6-methoxy-pyridine-2-carboxylate dissolved in 10 mL of acetonitrile. The reaction mixture was stirred at 80 °C for 1 h and then poured into ice water, acidified with 4 M aqueous HCl and extracted with EtOAc. The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by fast chromatography (eluent ratio: petroleum ether/EtOAc 3/1→2/1). A product of 650 mg was obtained in 49% yield. eSI-MS: m/z = 202 (M + H)+. hPLC retention time: 1.12 min (Method 5).
References
[1] Patent: WO2013/87805, 2013, A1. Location in patent: Page/Page column 75
[2] Patent: US2013/158042, 2013, A1. Location in patent: Paragraph 0477; 0478; 0479; 0480; 0481
Methyl 4-chloro-6-Methoxypicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-chloro-6-Methoxypicolinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Shanghai Anmike Chemical Co. Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 9988 | 55 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| ShangHai Book Chemical Co., Ltd. | 15001988657 15802146997 | info@bookchemicals.com | China | 970 | 58 |
| SuZhou Medinoah Co.,LTD. | 0512-69561983 13914027025 | zhang_q@medinoah.com | China | 3925 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55055611 18137792234 | 3957071458@qq.com | China | 9969 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | sale03@alfachem.cn | China | 9872 | 58 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | 85521272 18932438858 | sales@chemfish.com | China | 7780 | 58 |
