MS417
- CAS No.
- 916489-36-6
- Chemical Name:
- MS417
- Synonyms
- MS147;MS417;GTPL7512;MS-417; M S417;MS417（GTPL7512）;methyl(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-methyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;Epigenetic Reader Domain,inhibit,MS417,HIV,MS 417,GTPL 7512,Inhibitor,MS-417,GTPL-7512,Human immunodeficiency virus;methyl 2-((6S,Z)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, methyl ester, (6S)-
- CBNumber:
- CB92748943
- Molecular Formula:
- C20H19ClN4O2S
- Molecular Weight:
- 414.91
- MDL Number:
- MFCD20526583
- MOL File:
- 916489-36-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MS417 ≥98% (HPLC) | SML2442 | 5mg | $143 |
| MS417 ≥98% (HPLC) | SML2442 | 25mg | $371 |
| MS417 | RLB48936 | 25mg | $879.5 |
| MS417 | RLB48936 | 50mg | $1407 |
| MS417 | RLB48936 | 100mg | $1958 |
| Boiling point | 596.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Ethanol : 50 mg/mL (120.51 mM) |
| pka | 1.86±0.60(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| InChIKey | GGRCIHACOIMRKY-HNNXBMFYSA-N |
| SMILES | O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
MS417 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2442 | MS417 ≥98% (HPLC) | 916489-36-6 | 5mg | $143 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2442 | MS417 ≥98% (HPLC) | 916489-36-6 | 25mg | $371 | 2026-04-30 | Buy |
| Biosynth | RLB48936 | MS417 | 916489-36-6 | 25mg | $879.5 | 2026-06-05 | Buy |
| Biosynth | RLB48936 | MS417 | 916489-36-6 | 50mg | $1407 | 2026-06-05 | Buy |
| Biosynth | RLB48936 | MS417 | 916489-36-6 | 100mg | $1958 | 2026-06-05 | Buy |
MS417 Chemical Properties,Uses,Production
Uses
MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM).
Definition
ChEBI: MS-417 is a member of the class of thienotriazolodiazepines that is the methyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. A bromodomain and extra-terminal domain (BET)-specific inhibitor that belongs to a group of thienodiazepine-based compounds It is a thienotriazolodiazepine, a member of monochlorobenzenes and a methyl ester. It is an enantiomer of a MS-566.
Biological Activity
MS417, a (+)-JQ1 analog, is a potent inhibitor of bromodomain-containing protein 4 (BRD4) th at is highly specific for BRD4-BD1 and BRD4-BD2. MS417 binds with similar affinity to BRD4-BD1 and BRD4-BD2 (Kd =36.1, and 25.4 nM), while bulky tBu of JQ1 prevents tight binding to the cavity at BD1.
in vivo
MS417 (0.08 mg/kg) markedly improves renal function, reduces proteinuria and decreases glomerulosclerosis, tubular injury, and infiltration of inflammatory cells in the kidney of Tg26 mice[1].
References
[1] Zhang G, et al. Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51. DOI:10.1074/jbc.M112.359505
MS417 Preparation Products And Raw materials
Raw materials
Preparation Products
MS417 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11674 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Soochow Chirally Material Science and Technology Co.,Ltd | +86-51266834346 +86-17751128648 | sales@krl-tech.com | China | 1050 | 58 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| DONGSHENG CHIRAL PHARMA | 15800326364 18051538752 | 582512789@qq.com | China | 447 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
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