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Cortisone acetate

Cortisone acetate Structure
Cortisone acetate structure
CAS No.
50-04-4
Chemical Name:
Cortisone acetate
Synonyms
CORTISONE 21-ACETATE;2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-diMethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;artriona;cortelan;cortisyl;ricortex;NSC 49420;cortistab;biocortacetate;cortoneacetate
CBNumber:
CB9277612
Molecular Formula:
C23H30O6
Molecular Weight:
402.48
MDL Number:
MFCD00003609
MOL File:
50-04-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:20:31
Product description Number Pack Size Price
Cortisone acetate European Pharmacopoeia (EP) Reference Standard C2800000 250 mg $241
Cortisone acetate British Pharmacopoeia (BP) Reference Standard BP585 100MG $229
Cortisone acetate European Pharmacopoeia (EP) Reference Standard C2800000 c2800000 $220
Cortisone Acetate ≥98% 23798 5g $69
Cortisone Acetate ≥98% 23798 10g $127
More product size
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Cortisone acetate Properties

Melting point 237-240 °C(lit.)
alpha D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
Boiling point 577.3±50.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
refractive index 212 ° (C=1, MeOH)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
pka 12.32±0.60(Predicted)
form Solid
color White to Off-White
Water Solubility 19mg/L(25 ºC)
Merck 14,2539
BRN 2067543
Stability Stable. Incompatible with strong oxidizing agents.
Major Application pharmaceutical
InChIKey ITRJWOMZKQRYTA-RFZYENFJSA-N
SMILES O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)C(=O)C2)CC1)C)C(=O)COC(=O)C
CAS DataBase Reference 50-04-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 883WKN7W8X
EPA Substance Registry System Cortisone acetate (50-04-4)
UNSPSC Code 12352211
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H373-H361
Precautionary statements  P260-P314-P501-P201-P202-P281-P308+P313-P405-P501
Safety Statements  22-36/37-24/25
WGK Germany  3
RTECS  GM9140000
HS Code  32041200
Storage Class 11 - Combustible Solids
Hazard Classifications Repr. 2
REACH Registrations Active
NFPA 704
0
3 0

Cortisone acetate price More Price(98)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C2800000 Cortisone acetate European Pharmacopoeia (EP) Reference Standard 50-04-4 250 mg $241 2026-04-30 Buy
Sigma-Aldrich BP585 Cortisone acetate British Pharmacopoeia (BP) Reference Standard 50-04-4 100MG $229 2026-04-30 Buy
Sigma-Aldrich C2800000 Cortisone acetate European Pharmacopoeia (EP) Reference Standard 50-04-4 c2800000 $220 2024-03-01 Buy
Cayman Chemical 23798 Cortisone Acetate ≥98% 50-04-4 5g $69 2026-04-30 Buy
Cayman Chemical 23798 Cortisone Acetate ≥98% 50-04-4 10g $127 2026-04-30 Buy
Product number Packaging Price Buy
C2800000 250 mg $241 Buy
BP585 100MG $229 Buy
C2800000 c2800000 $220 Buy
23798 5g $69 Buy
23798 10g $127 Buy

Cortisone acetate Chemical Properties,Uses,Production

Description

Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.

Chemical Properties

White needle crystal or crystalline powder (acetone), odorless. Stable in the air. Mp239- 241°C, specific rotation [α]20D+164°(0.5%, acetone), [α]23D+169°(chloroform), [α]25D+208°-+217°(dioxane), The ethanol solution of this product has a maximum absorption at a wavelength of 240nm. Soluble in chloroform (1:4), soluble in acetone (1:75), slightly soluble in ethanol and ether, and hardly soluble in water. This product dissolves in sulfuric acid and turns yellow without fluorescence (different from hydrocortisone acetate).

Originator

Cortone Acetate,MSD,US,1950

Uses

Cortisone Acetate (Hydrocortisone Acetate EP Impurity D) is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone.

Definition

ChEBI: Cortisone acetate is a corticosteroid hormone.

Preparation

Cortisone acetate is prepared from dehydropregnenolone by epoxidation, Wolff's oxidation, mycoxidation, chromic acid oxidation, hydrogen bromide ring-opening, Raney's nickel-catalyzed debromination, iodination, and acetyloxy substitution.

Therapeutic Function

Glucocorticoid

General Description

Cortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.

Purification Methods

Crystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]

References

1. Cortisone acetate in skin disease; local effect in the skin from topical application and local injection. DOI:10.1001/ARCHDERM.1952.01530210056007
2. McCue, R.E., Dannenberg, A.M., Jr., Huguchi, S., et al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation 3(2), 159-176 (1978). DOI:10.1007/BF00910737
3. Joseph, J., and Tydd, M. The effects of cortisone acetate on tissue regeneration in the rabbit’s ear. J. Anat. 115(Pt. 3), 445-460 (1973).
4. Schlechte, J.A., Ginsberg, B.H., and Sherman, B.M. Regulation of the glucocorticoid receptor in human lymphocytes. J. Steroid Biochem. 16(1), 69-74 (1982). DOI:10.1016/0022-4731(82)90145-5
5. Sittig's Pharmaceutical Manufacturing Encyclopedia
6. Textbook of organic medicinal and pharmaceutical chemistry. DOI:10.1002/jps.3030451120
7. Purification of Laboratory Chemicals DOI:10.5860/choice.50-6768

Cortisone acetate synthesis

7753-60-8
50-04-4
Synthesis of Cortisone acetate from Anecortave Acetate

Cortisone acetate Preparation Products And Raw materials

Raw materials

16-Dehydropregnenolone Hydrogen peroxide Nickel Chromic acid Chromium(VI) oxide
16-Dehydropregnenolone acetate CORTISONE 16a,17a-Epoxyprogesterone Potassium Acetate Saponin
POTASSIUM CYANIDE Acetic acid Osmium tetroxide Pregn-5-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal) Pregn-4-ene-3,11,20-trione, 9-bromo-17,21-dihydroxy-, 21-acetate
Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate Anecortave Acetate

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Preparation Products

Prednisone 21-acetate Prednisone Hydrocortisone

Cortisone acetate Suppliers

Global( 393)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Kangcang new material Technology Co., LTD
+8615713292910 Nancy@kangcang.com.cn China 341 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5983 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 904 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6366 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5742 58
Supplier Advantage
Hebei Kangcang new material Technology Co., LTD
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Xiamen AmoyChem Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58

Related articles

View Lastest Price from Cortisone acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cortisone acetate pictures 2026-06-05 Cortisone acetate
50-04-4
 1kg 98%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
Cortisone acetate pictures 2026-04-22 Cortisone acetate
50-04-4
 $29.00 99.93% 10g TargetMol Chemicals Inc.
Cortisone acetate pictures 2026-04-20 Cortisone acetate
50-04-4
 $29.00 99.93% 10g TargetMol Chemicals Inc.

Cortisone acetate Spectrum

Cortisone acetate(50-04-4)MSCortisone acetate(50-04-4)1HNMRCortisone acetate(50-04-4)13CNMRCortisone acetate(50-04-4)IR1Cortisone acetate(50-04-4)IR2Cortisone acetate(50-04-4)Raman

50-04-4(Cortisone acetate)Related Search:

Cellulose acetate Vinyl acetate Ethyl acetate Sodium acetate POLY(VINYL ACETATE)
Hydrocortisone Hydrocortisone acetate Ammonium acetate Glatiramer acetate CORTISONE
ACETATE 21-DEOXYCORTISONE CORTISONE ACETATE DIETHYLENEKETAL Cortisone acetate CORTISONE-21-ACETATE (CORTISONE ACETATE)
Cortisone Acetate, Powder CORTISONE ACETATE USP 23 CORTISONE ACETATE IMP. A (EP): HYDROCORTISONE ACETATE

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11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate 11-dehydro-17-hydroxycorticosterone-21-acetate 11-dehydro-17-hydroxycorticosteroneacetate 17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate 4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE 4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE 4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE 17,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE 21 ACETATE CORTISONE ACETATE DELTA4-PREGNEN-17ALPHA-21-DIOL-3, 11, 20-TRIONE-21-ACETATE ACETIC ACID 2-((8S,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3,11-DIOXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER 21-acetoxypregnen-17a-ol-3,11,20-trione 21-Acetoxypregnen-17alpha-ol-3,11,20-trione Cortisoneacetate,99% Cortison Acetate CORTISONE ACETATE CRYSTALLINE CORTISONE-21-ACETATE, PH EUR KENDALL'S COMPOUND 'E' ACETATE Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy- CORTISONEACETATE,MICRONIZED,USP CORTISONEACETATE,POWDER,USP 21-Acetoxy-17-hydroxypregn-4-ene-3,11,20-trione 21-Acetoxy-17α-hydroxy-3,11,20-triketopregnene-4 21-Acetoxy-17α-hydroxypregn-4-ene-3,11,20-trione 4-Pregnene-17a,21-diol-3,11,20-trione 21-acetate Cortisone, 21-acetate (8CI) Cortisyl Artriona NSC 49420 Cortisone acetate, 98.5% 20-trione,21-(acetyloxy)-17-hydroxy-pregn-4-ene-11 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione 21-acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4 21-acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione acetatecortisone artriona biocortacetate compoundeacetate cortelan cortisonemonoacetate cortistab cortisyl cortogenacetate cortoneacetate irisoneacetate ricortex Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate (7CI) 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate, Cortisoni acetas 17,21-dihydroxypregn-4-ene-3,11,20-trione acetat Cortisone Acetate (150 mg) Cortison phosphate Cortone 21-Acetate CORTISONE ACETATE ONISED IMp. A (EP): Hydrocortisone Acetate 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate